2020
DOI: 10.1186/s13075-020-02161-8
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Higher interferon score and normal complement levels may identify a distinct clinical subset in children with systemic lupus erythematosus

Abstract: Background: Systemic lupus erythematosus (SLE) is a complex multi-system disease, characterized by both autoimmune and autoinflammatory clinical and laboratory features. The role of type I interferon (IFN) in SLE has been demonstrated from the 2000s, by gene expression analyses showing significant over-expression of genes related to type I IFN signalling pathway (IFN signature). However, several studies questioned the role of measuring the intensity of IFN signature (IFN score) to chase SLE activity. We would … Show more

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Cited by 27 publications
(19 citation statements)
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“…This could translate to an immune complex driven disease state in C4, where the type I interferon process was active (low lymphocyte percent and increased neutrophil involvement). In studies using independent patient groups, both changes in complement ratio (C3/C4) 21 and the categorisation of neutrophil to lymphocyte ratio (NLR) 22 , have been suggested as ways to distinguish SLE patient groups. Here, network analysis and unsupervised clustering combined both C3/C4 and NLR biomarker sets and resulted in three separate groups spanning these factors.…”
Section: Discussionmentioning
confidence: 99%
“…This could translate to an immune complex driven disease state in C4, where the type I interferon process was active (low lymphocyte percent and increased neutrophil involvement). In studies using independent patient groups, both changes in complement ratio (C3/C4) 21 and the categorisation of neutrophil to lymphocyte ratio (NLR) 22 , have been suggested as ways to distinguish SLE patient groups. Here, network analysis and unsupervised clustering combined both C3/C4 and NLR biomarker sets and resulted in three separate groups spanning these factors.…”
Section: Discussionmentioning
confidence: 99%
“…This could translate to an immune complex driven disease state in C5, where the type I interferon process was active (low lymphocyte percent and increased neutrophil involvement). In studies using independent patient groups, both changes in complement ratio (C3/C4) 21 and the categorisation of neutrophil to lymphocyte ratio (NLR) 22 , have been suggested as ways to distinguish SLE patient groups.…”
Section: Discussionmentioning
confidence: 99%
“…This finding offers a very promising target for therapy and even prevention of such autoimmune diseases. Moreover, the integration between IFN signature analysis and other laboratory indices, such as complement levels, seems to help to stratify paediatric SLE patients into two groups, in which the autoimmune or autoinflammatory component of the disease are prevalent, with different response to treatment [255].…”
Section: Ifnopathiesmentioning
confidence: 99%