Higher insulin and higher body fat via leptin are associated with disadvantageous decisions in the Iowa gambling task

Abstract

Elevated body mass index and post-prandial state are associated with disadvantageous choices on the Iowa Gambling Task (IGT). Whether physiological factors including percent body fat, and peripheral glucose, insulin, and leptin concentrations, are associated with IGT performance is unknown. In 196 healthy adults without diabetes, we measured body fat by DXA scan, glucose, insulin and leptin (n=138) concentrations during an oral glucose tolerance test and IGT performance after a standardized meal. Glucose was not associated with IGT performance. Disadvantageous IGT performance was associated with higher percent body fat (r = −0.16, p = 0.03), 30-min insulin concentrations (insulin30, r = −0.27, p < 0.001), and 30-min leptin concentrations (leptin30, r = −0.23, p=0.008). Mediation analysis demonstrated that leptin30 was almost completely responsible for the percent body fat effect on IGT performance. Even adjusted for age, sex, race, and education, insulin30 (b = −46.5, p = 0.03) and leptin30 (b = −50.9, p = 0.03) concentrations remained independently associated with IGT performance and interacted together such that higher leptin30 blunted effects of higher insulin30 (b = 23.8, p = 0.048). These findings may indicate an internal metabolic signature of energy availability (higher body fat, insulin, and leptin levels) associated with disadvantageous IGT performance.

Obesity, Appetite, and the Prefrontal Cortex

“…One possible explanation for these findings is that increases in perseveration could intensify cognitive restraint, thereby contributing to more binge cycles in obesity [10]. Studies from our lab have also shown that higher leptin levels, commonly associated with greater percent body fat and increased food intake as seen in obesity [37] correlated to disadvantageous performance on the Iowa Gambling Task (IGT), a measure of decision making [38]. Higher scores on the IGT were associated with a greater amount of weight loss in obese women [27].…”