Higher Incidence of Tall Cell Variant of Papillary Thyroid Carcinoma in Graves' Disease

Boutzios, Georgios; Vasileiadis, Ioannis; Zapanti, Evangelia; Charitoudis, Georgios; Karakostas, Efthimios; Ieromonachou, Panagiotis; Karatzas, Theodore

doi:10.1089/thy.2013.0133

Cited by 34 publications

(23 citation statements)

References 32 publications

(36 reference statements)

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“…A more recent prospective study has shown that in patients with thyroid nodules elevated serum concentration of Tg Ab, but not serum thyroid peroxidase Ab, is an independent predictor for thyroid cancer [42]. Our findings are also in agreement with studies that showed that patients with Graves' disease are at a higher risk of thyroid carcinoma [43,44,45]. …”

Section: Discussionsupporting

confidence: 91%

Prevalence of Cancer in Patients with Thyroid Nodules in the Island of Cyprus: Predictive Value of Ultrasound Features and Thyroid Autoimmune Status

Hadjisavva¹,

Dina²,

Talias³

et al. 2015

Eur Thyroid J

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Background: The purpose of this study was to determine the prevalence of thyroid carcinoma in patients who underwent ultrasound-guided fine needle aspiration biopsy (USgFNA) of thyroid nodules in the island of Cyprus. Ultrasound features as well as the presence of autoimmune thyroid disease were evaluated as risk factors for malignancy. Methods: 322 consecutively examined patients (272 females/50 males, age 13-81) underwent USgFNA of thyroid nodules in a referral endocrine clinic between July 2007 and July 2009. The ultrasonographic characteristics examined were: echogenicity, margin irregularity, composition, calcifications, presence of increased vasculature and nodule size. The presence or absence of autoimmune thyroid disease was recorded. Results: From the 548 nodules examined, 74 (13.6%) were classified as THY3, 4 or 5. 75 patients (123 nodules) underwent surgical resection. 46 patients (64 nodules) proved to have thyroid carcinoma by histology. There was a significant correlation of suspicious/malignant cytology with solid composition, hypoechogenicity, irregular margins and the presence of calcifications. A significant association was also noted between the presence of positive antithyroglobulin antibodies (p < 0.05) and Graves' disease (p = 0.01) with suspicious/malignant cytology. Conclusion: The overall prevalence of thyroid cancer was 14.3%. Ultrasound characteristics were highly predictive of thyroid malignancy. Thyroid autoimmunity should be considered as a risk factor.

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Section: Discussionsupporting

confidence: 91%

Prevalence of Cancer in Patients with Thyroid Nodules in the Island of Cyprus: Predictive Value of Ultrasound Features and Thyroid Autoimmune Status

Hadjisavva¹,

Dina²,

Talias³

et al. 2015

Eur Thyroid J

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“…We explored the conventional (i.e., the miRNA−target relationships) and unconventional properties (i.e., the protein-coding ceRNA network and the indirect, modulatory contribution) of PTC miRNAs, providing valuable information about critical miRNAs and mRNAs from respective networks linking to the tumor biology. Consistent with our findings, a subset of Hashimoto's thyroiditis harbored some precursor lesions with molecular characteristics of PTC3839, suggesting frequent lymphocytic infiltration in this malignancy, and a higher incidence rate of TCPTC in patients with Graves' disease was also reported40. In this study, we demonstrated that TCPTC and, secondly, CPTC possess more immune activities under miRNA regulation than FPTC, indicating the involvement of immunological factors to different extents in PTC variants.…”

Section: Discussionsupporting

confidence: 89%

MicroRNA-mediated networks underlie immune response regulation in papillary thyroid carcinoma

Huang

Oyang

Huang³

et al. 2014

Sci Rep

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Papillary thyroid carcinoma (PTC) is a common endocrine malignancy with low death rate but increased incidence and recurrence in recent years. MicroRNAs (miRNAs) are small non-coding RNAs with diverse regulatory capacities in eukaryotes and have been frequently implied in human cancer. Despite current progress, however, a panoramic overview concerning miRNA regulatory networks in PTC is still lacking. Here, we analyzed the expression datasets of PTC from The Cancer Genome Atlas (TCGA) Data Portal and demonstrate for the first time that immune responses are significantly enriched and under specific regulation in the direct miRNA−target network among distinctive PTC variants to different extents. Additionally, considering the unconventional properties of miRNAs, we explore the protein-coding competing endogenous RNA (ceRNA) and the modulatory networks in PTC and unexpectedly disclose concerted regulation of immune responses from these networks. Interestingly, miRNAs from these conventional and unconventional networks share general similarities and differences but tend to be disparate as regulatory activities increase, coordinately tuning the immune responses that in part account for PTC tumor biology. Together, our systematic results uncover the intensive regulation of immune responses underlain by miRNA-mediated networks in PTC, opening up new avenues in the management of thyroid cancer.

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“…with AITD than in those without AITD and that they may be a 209 premalignant condition to PTC [20,21,22]. Our results, concerning 210 lymphoid cells, demonstrate unprecedently that these cells are 211 attacked by oxidative damage in PTC and AITD.…”

mentioning

confidence: 68%

A comparative study of nuclear 8-hydroxyguanosine expression in Autoimmune Thyroid Diseases and Papillary Thyroid Carcinoma and its relationship with p53, Bcl-2 and Ki-67 cancer related proteins

Mseddi

Mansour

Gouiia

et al. 2017

Advances in Medical Sciences

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Higher Incidence of Tall Cell Variant of Papillary Thyroid Carcinoma in Graves' Disease

Cited by 34 publications

References 32 publications

Prevalence of Cancer in Patients with Thyroid Nodules in the Island of Cyprus: Predictive Value of Ultrasound Features and Thyroid Autoimmune Status

Prevalence of Cancer in Patients with Thyroid Nodules in the Island of Cyprus: Predictive Value of Ultrasound Features and Thyroid Autoimmune Status

MicroRNA-mediated networks underlie immune response regulation in papillary thyroid carcinoma

A comparative study of nuclear 8-hydroxyguanosine expression in Autoimmune Thyroid Diseases and Papillary Thyroid Carcinoma and its relationship with p53, Bcl-2 and Ki-67 cancer related proteins

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