Higher incidence of reported adverse events following immunisation (AEFI) after first dose of COVID-19 vaccine among previously infected health care workers

Real-World Use and Adverse Events of SARS-CoV-2 Vaccination in Greek Patients with Inflammatory Bowel Disease

“…In agreement with previous studies, we showed that prior COVID-19 infection is correlated with the presence of AEs to vaccination [21,22]. Moreover, a statistically significant increase of systemic AEs after D2 compared to D1 was reported.…”

“…Moreover, a statistically significant increase of systemic AEs after D2 compared to D1 was reported. Both findings can be interpreted by the induction of a pre-existing immunization process from prior COVID-19 infection and D1, respectively [21,22]. In keeping with this observation, there is evidence that these populations present with higher post vaccination antibody titers [22].…”

Adverse events following immunisation (AEFI) after first dose of COVID-19 vaccine

“…We would like to share ideas on “Higher incidence of reported adverse events following immunisation (AEFI) after first dose of COVID-19 vaccine among previously infected health care workers”. 1 Adverse event after vaccination is an interesting issue at present. The difference in the incidence of AEFI among ones with and without previous COVID might be due to many reasons.…”

Serological assessment is advisable before COVID-19 vaccination

“…We read with interest the article of Joshi et al., 1 who reported that previously infected healthcare workers receiving coronavirus disease 2019 (COVID-19) vaccination experimented a higher incidence of adverse events following immunization (AEFI). This important finding provides substantial support to the previous evidence that vaccine reactogenicity, along with the consequent risk of developing local or systemic reactions, is magnified in subjects who recovered from a previous severe acute respiratory disease coronavirus 2 (SARS-CoV-2) infection, either symptomatic or asymptomatic.…”

“…in their study. 1 The second important aspect is that we and others have shown that the humoral response developing after COVID-19 vaccination is orders of magnitude higher in healthcare workers with previous SARS-CoV-2 infection than in those without, 4 , 5 such that a dose reduction (i.e., lowering the dosage of single-administration vaccines or averting the booster in two-dose vaccines recipients) may be advisable. This will contribute to optimize vaccine usage and reduce their worldwide shortage, especially in more vulnerable countries, including India.…”