2023
DOI: 10.1093/hmg/ddad160
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Higher incidence of embryonic defects in mouse offspring conceived with assisted reproduction from fathers with sperm epimutations

Gurbet Karahan,
Josée Martel,
Sophia Rahimi
et al.

Abstract: Assisted reproductive technologies (ART) account for 1–6% of births in developed countries. While most children conceived are healthy, increases in birth and genomic imprinting defects have been reported; such abnormal outcomes have been attributed to underlying parental infertility and/or the ART used. Here, we assessed whether paternal genetic and lifestyle factors that are associated with male infertility and affect the sperm epigenome, can influence ART outcomes. We examined how paternal factors, haploinsu… Show more

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“…Epigenetic alterations induced by a Western diet in male germline cells can cause subfertility by affecting sperm quality [ 12 ]. Furthermore, offspring can inherit these alterations [ 17 , 18 , 19 ]. Spermatogenesis also involves the remodeling of chromatin.…”
Section: Introductionmentioning
confidence: 99%
“…Epigenetic alterations induced by a Western diet in male germline cells can cause subfertility by affecting sperm quality [ 12 ]. Furthermore, offspring can inherit these alterations [ 17 , 18 , 19 ]. Spermatogenesis also involves the remodeling of chromatin.…”
Section: Introductionmentioning
confidence: 99%