2003
DOI: 10.1002/mds.10387
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Higher incidence of depression preceding the onset of Parkinson's disease: A register study

Abstract: Although case histories of depression preceding Parkinson's disease (PD) point to a possible pathophysiological relationship between these two disorders, there is as yet no epidemiological evidence to support this view. We compared the incidence of depression in patients later diagnosed with PD with that of a matched control population. Using data from an ongoing general practice-based register study, the lifetime incidence of depressive disorder was calculated for patients until their diagnosis of PD and comp… Show more

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Cited by 303 publications
(199 citation statements)
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References 37 publications
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“…A case-control study nested within a general practitioner database [564] also reported increased risk related to history of depression (OR 2.4, 95% CI 2.1-2.7). Average duration between first depressive episode and diagnosis of PD was 10 years, but with large variation.…”
Section: Mental Illnessmentioning
confidence: 98%
See 1 more Smart Citation
“…A case-control study nested within a general practitioner database [564] also reported increased risk related to history of depression (OR 2.4, 95% CI 2.1-2.7). Average duration between first depressive episode and diagnosis of PD was 10 years, but with large variation.…”
Section: Mental Illnessmentioning
confidence: 98%
“…Average duration between first depressive episode and diagnosis of PD was 10 years, but with large variation. No analyses focusing on time between onset of depression and PD were performed, but the authors noted that depression seemed to be more common shortly before PD diagnosis [564], questioning whether depression was an early manifestation of PD. Following individuals with and without depression for subsequent PD diagnosis using the same database also showed increased PD risk (HR 3.13, 95% CI 1.95-5.01, for depressed versus non-depressed individuals) [565].…”
Section: Mental Illnessmentioning
confidence: 99%
“…14,73,74 It is an adequate screening measure for dPD, but, like all scales and diagnostic criteria that include somatic items, it overlaps with core PD symptoms. As an observer-rated scale, it requires training, and self-report questionnaires may be more appropriate as screening instruments for dPD in routine clinical neurological clinics or in largescale epidemiological studies.…”
Section: Suitability For Studiesmentioning
confidence: 99%
“…Non-motor signs: prevalence, respective level of functional disability and potential role as premotor signs of Parkinson's disease 15,16,17,18,19,35,43,44,45,47,48,49,51,52,53,60 . healthy elderly individuals, those with proven olfactory deficit had a higher risk of developing symptomatic PD clinical and when they remained asymptomatic, these individuals presented LB in the SNc on post-mortem examination.…”
Section: Olfactory Deficitmentioning
confidence: 99%
“…Another epidemiological study found similar results with a chance of 2.95 times for the occurrence of PD in individuals with depression. In these studies and in the literature in general, depression is considered a risk factor, as well as family history and life in a rural environment, but not necessarily a pre-motor symptom 44 .…”
Section: Behavioral Disordersmentioning
confidence: 99%