Higher growth rate and gene expression in male zebra finch embryos are independent of manipulation of maternal steroids in the eggs

Lutyk, Dorota; Tagirov, Makhsud; Drobniak, Szymon M.; Rutkowska, Joanna

doi:10.1016/j.ygcen.2017.09.004

Cited by 3 publications

(4 citation statements)

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“…Hormonal influence on gene expression patterns could lead to modifications of breeding values underlying phenotypes, and eventually to changes in the levels of genetic variance. Some studies suggests that in ovo corticosterone can induce gene expression changes in birds (Ahmed et al 2016), but such evidence is not unambiguous (Lutyk et al 2017). Function of corticosteroid receptors as transcription factors directly modulating expression of certain genes is known (Kawata 1995;Baker 1997).…”

Section: Discussionmentioning

confidence: 99%

“…It is therefore likely that hormonally mediated maternal effect may be one of the factors mediating the observed patterns of G × E in wild populations. Steroid hormones are particularly interesting in this context: they have profound effects on offspring development (Hayward and Wingfield 2004;Tschirren et al 2005Tschirren et al 2009Tobler and Sandell 2007;Coslovsky et al 2012;Ruuskanen et al 2012;Schweitzer et al 2013;Lutyk et al 2017) and they can directly impact the expression of genes by acting as transcription modulators in the nuclei of cells after binding to their specific receptors (Kawata 1995;Baker 1997;Podmokła et al 2018). As such, steroid hormones are well documented as mediators of maternal effects, and one reason for this is the ease of manipulating their levels in eggs of wild birds (Groothuis and Schwabl 2008).…”

Section: Introductionmentioning

confidence: 99%

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Differential effects of steroid hormones on levels of broad-sense heritability in a wild bird: possible mechanism of environment × genetic variance interaction?

et al. 2021

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Genetic variation is one of the key concepts in evolutionary biology and an important prerequisite of evolutionary change. However, we know very little about processes that modulate its levels in wild populations. In particular, we still are to understand why genetic variances often depend on environmental conditions. One of possible environment-sensitive modulators of observed levels of genetic variance are maternal effects. In this study we attempt to experimentally test the hypothesis that maternally transmitted agents (e.g. hormones) may influence the expression of genetic variance in quantitative traits in the offspring. We manipulated the levels of steroid hormones (testosterone and corticosterone) in eggs laid by blue tits in a wild population. Our experimental setup allowed for full crossing of genetic and rearing effects with the experimental manipulation. We observed that birds treated with corticosterone exhibited a significant decrease in broad-sense genetic variance of tarsus length, and an increase in this component in body mass on the 2nd day post-hatching. Our study indicates, that maternally transmitted substances such as hormones may have measurable impact on the levels of genetic variance and hence, on the evolutionary potential of quantitative traits.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differential effects of steroid hormones on levels of broad-sense heritability in a wild bird: possible mechanism of environment × genetic variance interaction?

et al. 2021

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“…Other mechanism that can be invoked in cases of condition-varying genetic variances involves changes in gene expression at a molecular level (Hodgins-Davis and Townsend, 2009). Sparse evidence suggests, that in ovo CORT can induce gene expression changes in birds (Ahmed et al, 2016), but such evidence is not unambiguous (Lutyk et al, 2017). Function of corticosteroids' receptors as transcription factors directly modulating expression of certain genes is known (Kawata, 1995;Baker, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Some of those mechanisms can directly affect the expression of genes in the offspring. Steroid hormones are a good candidate: they have profound effects on offspring development (Hayward and Wingfield, 2004;Tobler and Sandell, 2007;Tschirren et al, 2009;Coslovsky et al, 2012;Ruuskanen et al, 2012;Schweitzer et al, 2013;Lutyk et al, 2017); they directly impact the expression of genes by acting as transcription modulators in the nuclei of cells after binding to their specific receptors (Kawata, 1995;Baker, 1997;Podmokła et al, 2018); they are often involved in modulation and transduction of external cues such as stressful external conditions (Coslovsky et al, 2012;Podmokła et al, 2018;Öst et al, 2019). As such, steroid hormones are well documented as mediators of maternal effects, and one reason for this is the ease of manipulating their levels in eggs of wild birds (Tschirren, Saladin, et al, 2005;Ruuskanen et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Differential effects of steroid hormones on levels of genetic variance in a wild bird: possible mechanism of maternal-effects x genetic variance interaction?

Drobniak¹,

Sudyka²,

Cichoń³

et al. 2020

Preprint

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Genetic variation is one of the key concepts in evolutionary biology and an important prerequisite of evolutionary change. Still, we know very little about processes that modulate its levels in wild populations. In particular – we still are to understand why genetic variances often depend on environmental conditions. One of possible environment-sensitive modulators of observed levels of genetic variance are maternal effects. In this study we attempt to experimentally test the hypothesis that maternally-transmitted agents (e.g. hormones) may influence the expression of genetic variance in quantitative traits in the offspring. We manipulated the levels of steroid hormones (testosterone and corticosterone) in eggs laid by blue tits in a wild population. Our experimental setup allowed for full crossing of genetic and rearing effects with the experimental manipulation. We observed, that birds treated with corticosterone exhibited a significant decrease in genetic variance of tarsus length. We also observed less pronounced, marginally significant effects of hormonal administration on the patterns of genetic correlations between traits expressed under varying pre-hatching hormonal conditions. Our study indicates, that maternally transmitted substances such as hormones may have measurable impact on the levels of genetic variance – and hence, on the evolutionary potential of quantitative traits.

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Developmental programming by prenatal sounds: insights into possible mechanisms

Mariette

2024

Journal of Experimental Biology

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In recent years, the impact of prenatal sound on development, notably for programming individual phenotypes for postnatal conditions, has increasingly been revealed. However, the mechanisms through which sound affects physiology and development remain mostly unexplored. Here, I gather evidence from neurobiology, developmental biology, cellular biology and bioacoustics to identify the most plausible modes of action of sound on developing embryos. First, revealing often-unsuspected plasticity, I discuss how prenatal sound may shape auditory system development and determine individuals' later capacity to receive acoustic information. I also consider the impact of hormones, including thyroid hormones, glucocorticoids and androgen, on auditory plasticity. Second, I review what is known about sound transduction to other – non-auditory – brain regions, and its potential to input on classical developmental programming pathways. Namely, the auditory pathway has direct anatomical and functional connectivity to the hippocampus, amygdala and/or hypothalamus, in mammals, birds and anurans. Sound can thus trigger both immediate and delayed responses in these limbic regions, which are specific to the acoustic stimulus and its biological relevance. Third, beyond the brain, I briefly consider the possibility for sound to directly affect cellular functioning, based on evidence in earless organisms (e.g. plants) and cell cultures. Together, the multi-disciplinary evidence gathered here shows that the brain is wired to allow multiple physiological and developmental effects of sound. Overall, there are many unexplored, but possible, pathways for sound to impact even primitive or immature organisms. Throughout, I identify the most promising research avenues for unravelling the processes of acoustic developmental programming.

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Higher growth rate and gene expression in male zebra finch embryos are independent of manipulation of maternal steroids in the eggs

Cited by 3 publications

References 52 publications

Differential effects of steroid hormones on levels of broad-sense heritability in a wild bird: possible mechanism of environment × genetic variance interaction?

Differential effects of steroid hormones on levels of broad-sense heritability in a wild bird: possible mechanism of environment × genetic variance interaction?

Differential effects of steroid hormones on levels of genetic variance in a wild bird: possible mechanism of maternal-effects x genetic variance interaction?

Developmental programming by prenatal sounds: insights into possible mechanisms

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