Higher ferritin levels in COVID-19 patients are associated with hyperinflammation, worse prognosis, and more bacterial infections without pronounced features of hemophagocytosis

Lucijanić, Marko; Demaria, Martina; Gnjidić, Jelena; Rob, Zrinka; Filipović, Dora; Penović, Toni; Jordán, Ana; Barišić-Jaman, Mislav; Paštrović, Frane; Lucijanić, D.; Čikara, Tomislav; Lucijanić, Tomo; Miletic, Marko; Ljubičić, Đivo; Kereš, Tatjana

doi:10.1007/s00277-022-04813-y

Cited by 5 publications

(3 citation statements)

References 3 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated ferritin levels have indeed been to a variety of inflammatory and infectious illnesses. Increased ferritin levels were linked to higher mortality and the requirement for mechanical ventilation [32,33]. In their study, Carubbi et al, demonstrated that greater ferritin levels are related to more severe lung damage as seen by computed tomography [34].…”

Section: Discussionmentioning

confidence: 95%

Predictors of Noninvasive Respiratory Support Failure in COVID-19 Patients: A Prospective Observational Study

et al. 2022

View full text Add to dashboard Cite

Background and Objective: Respiratory assistance tactic that is best for COVID-19-associated acute hypoxemic respiratory failure (AHRF) individuals has yet to be determined. Patients with AHRF may benefit from the use of a high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV). The goals of this prospective observational research were to estimate predictive factors for HFNC and NIV failure in COVID-19-related AHRF subjects. Materials and Methods: The research enlisted the participation of 124 patients. A stepwise treatment approach was used. HFNC and NIV were used on 124 (100%) and 64 (51.6%) patients, respectively. Thirty (24.2%) of 124 patients were intubated and received invasive mechanical ventilation. Results: 85 (68.5%) patients were managed successfully. Patients who required NIV exhibited a higher prevalence of treatment failure (70.3% vs. 51.6%, p = 0.019) and had higher mortality (59.4% vs. 31.5%, p = 0.001) than patients who received HFNC. Using logistic regression, the respiratory rate oxygenation (ROX) index at 24h (odds ratio (OR) = 0.74, p = 0.018) and the Charlson Comorbidity Index (CCI) (OR = 1.60, p = 0.003) were found to be predictors of HFNC efficacy. It was the ROX index at 24 h and the CCI optimum cut-off values for HFNC outcome that were 6.1 (area under the curve (AUC) = 0.73) and 2.5 (AUC = 0.68), respectively. Serum ferritin level (OR = 0.23, p = 0.041) and lymphocyte count (OR = 1.03, p = 0.01) were confirmed as predictors of NIV failure. Serum ferritin level at a cut-off value of 456.2 ng/mL (AUC = 0.67) and lymphocyte count lower than 0.70 per mm3, (AUC = 0.70) were associated with NIV failure with 70.5% sensitivity, 68.7% specificity and sensitivity of 84.1%, specificity of 56.2%, respectively. Conclusion: The ROX index at 24 h, CCI, as well as serum ferritin level, and lymphocyte count can be used as markers for HFNC and NIV failure, respectively, in SARS-CoV-2-induced AHRF patients.

show abstract

Section: Discussionmentioning

confidence: 95%

Predictors of Noninvasive Respiratory Support Failure in COVID-19 Patients: A Prospective Observational Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…2021/2503–04). This study was designed as a single center retrospective cohort study based on the Registry of Hospitalized Patients in University Hospital Dubrava Respiratory Center (ClinicalTrials.gov Identifier: NCT05151094), which included consecutive patients hospitalized with SARS-CoV‑2 positivity in the University Hospital Dubrava, a tertiary center, which has been designated shortly after the beginning of the pandemic as the principal and largest COVID-19 center in Croatia [ 31 , 32 ].…”

Section: Methodsmentioning

confidence: 99%

Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients

Salai

Vražić

Kovačević

et al. 2023

Wien Klin Wochenschr

Self Cite

View full text Add to dashboard Cite

Introduction The impact of asthma and chronic obstructive pulmonary disease (COPD) in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) infection is not clearly defined. Blood eosinophil count is a standard diagnostic test which, according to the previously published literature, might have a potential prognostic role on mortality in patients with SARS-CoV‑2 infection. Aim To investigate the potential prognostic value of peripheral blood eosinophil count on all-cause mortality of patients hospitalized with SARS-CoV‑2 infection, as well as to assess the impact of asthma or COPD premorbidity on all-cause mortality. Material and methods We conducted a retrospective registry-based cohort study. Survival analysis was performed by employing the Cox proportional hazards regression model at 30 days of follow-up. Prognostic value of eosinophil count on all-cause mortality was assessed using receiver-operating characteristic (ROC) curve analysis. Results A total of 5653 participants were included in the study. Our model did not reveal that pre-existing asthma or COPD is a statistically significant covariate for all-cause mortality but, indicated that higher eosinophil count at admission might have a protective effect (hazard ratio, HR 0.13 (95% confidence interval, CI 0.06–0.27), p = 0.0001). ROC curve analysis indicates cut-off value of 20 cells/mm 3 (81% specificity; 30.9% sensitivity). Conclusion Our results indicate that eosinophil count at hospital admission might have a potential prognostic role for all-cause mortality at 30 days of follow-up; however this was not demonstrated for pre-existing obstructive lung diseases.

show abstract

“…activation of lymphocytes and macrophages, against the background of their morphological goodness, is accompanied by a cytokine storm [14,16,19] and secondary hemophagocytic lymphohistiocytosis (HLH), which is a reflection of a life-threatening and prognostic condition [2,4,9]. It is known that secondary hemophagocytic lymphohistiocytosis (HLH) in clinical practice in most cases occurs in cancer patients.…”

mentioning

confidence: 99%

Hemophagocytosis in the Red Bone Marrow of Patients With Covid-19 With Sars-Cov-2 Infection

Reva¹,

Yamamoto²,

Slabenko³

et al. 2023

ArveMED

View full text Add to dashboard Cite

Red bone marrow samples investigation in deceased COVID-19 patients enabled to identify the phenomena of secondary hemophagocytosis. Analysis of the data showed that phagocytic reactions during infection of patients with SARS-CoV-2 are manifested both in relation to erythrocytes and leukocytes. The data obtained make it possible to expand the strategy of therapeutic measures, taking into account the new data on the mechanisms of the pathogenesis of COVID-19 in severe viral infection based on morphological findings and additional information on the involvement of young erythrocytes and lymphocytes in the structure of the red bone marrow in the cascade of pathological reactions. The results obtained confirm a wide range of aggressive damaging effects of SARS-CoV-2 in the development of multiple organ failure against the background of COVID-19 and the involvement of the red bone marrow in the pathological process. The authors supplemented information about the mechanisms of hypoxia in COVID-19, which is not only a consequence of damage to the respiratory epithelium, but also the result of damage to erythrocyte differons both at the level of red bone marrow and in peripheral blood. This fact must be taken into account in the development of a treatment strategy and in the creation of new drugs for the treatment of infected patients with various strains of SARS-CoV-2.

show abstract

Higher ferritin levels in COVID-19 patients are associated with hyperinflammation, worse prognosis, and more bacterial infections without pronounced features of hemophagocytosis

Cited by 5 publications

References 3 publications

Predictors of Noninvasive Respiratory Support Failure in COVID-19 Patients: A Prospective Observational Study

Predictors of Noninvasive Respiratory Support Failure in COVID-19 Patients: A Prospective Observational Study

Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients

Hemophagocytosis in the Red Bone Marrow of Patients With Covid-19 With Sars-Cov-2 Infection

Contact Info

Product

Resources

About