Higher dopamine transporter density in Parkinson’s disease patients with depression

Felı́cio, André Carvalho; Moriyama, Tais; Godeiro-Júnior, Clécio; Shih, Ming Chi; Hoexter, Marcelo Q.; Borges, Vanderci; Silva, Sônia M.A.; Amaro-Junior, Edson; Andrade, Luiz Augusto Franco de; Ferraz, Henrique Ballalai; Bressan, Rodrigo A.

doi:10.1007/s00213-010-1867-y

Cited by 63 publications

(46 citation statements)

References 18 publications

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“…Of the 38 studies on depression, 33 reported findings from one single imaging modality: 19 used either PET [11, 12, 13,15, 16, 17, 18, 19] or SPECT 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 techniques, four used T1‐weighted imaging 31, 32, 33, three used DTI 34, 35, 36, six used resting state functional MRI (RS‐FMRI) 37, 38, 39, 40, 41, 42 and two used TCS methods 43, 44. The remaining four of the 38 studies reported findings from structural T1‐weighted imaging plus another imaging method, including PET 14, DTI 45, task FMRI 46 and RS‐FMRI 47, respectively.…”

Section: Methodsmentioning

confidence: 99%

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Wen

Chan

Tan

et al. 2016

Euro J of Neurology

143

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Depression, anxiety and apathy are common mood disturbances in Parkinson's disease (PD) but their pathophysiology is unclear. Advanced neuroimaging has been increasingly used to unravel neural substrates linked to these disturbances. A systematic review is provided of neuroimaging findings in depression, anxiety and apathy in PD. A PubMed, MEDLINE and EMBASE search of peer‐reviewed original research articles on these mood disturbances in PD identified 38 studies on depression, eight on anxiety and 14 on apathy in PD. Most of the imaging studies used either position emission tomography or single‐photon emission computed tomography techniques. These studies generally suggest increased neural activity in the prefrontal regions and decreased functional connectivity between the prefrontal−limbic networks in depressed patients. Functional imaging studies revealed an inverse correlation between dopaminergic density in the caudate and putamen with the severity of anxiety in PD. There was no consistent correlation between dopaminergic density of thalamus and anxiety. Studies demonstrated both positive and inverse correlations between apathy and metabolism or activity in the striatum, amygdalar, prefrontal, temporal and parietal regions. The clinical variability of study subjects and differences in image pre‐processing and analytical strategies may contribute to discrepant findings in these studies. Both nigrostriatal and extra‐nigrostriatal pathways (in particular the frontal region and its connecting areas) are affected in mood disorders in PD. Identifying the relative contributions of these neural pathways in PD patients with overlapping motor and mood symptoms could provide new pathophysiological clues for the development of better therapeutic targets for affected patients.

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Section: Methodsmentioning

confidence: 99%

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Wen

Chan

Tan

et al. 2016

Euro J of Neurology

143

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“…In 99m Tc-TRODAT-1 SPECT [4,8], there was reduced TRODAT-1 uptake in the bilateral basal ganglia, especially on the left side ( Fig. 2a; Table 1).…”

Section: Introductionmentioning

confidence: 90%

Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea

Shih

et al. 2011

J Neurol

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We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) and (99m)Tc-labeled tropane dopamine transporter ((99m)Tc-TRODAT-1) single photon emission computed tomography (SPECT). Along with normalization of the hematocrit and clinical symptoms after consecutive phlebotomies, the FDG PET scan and (99m)Tc-TRODAT-1 SPECT images returned towards normal. It is hypothesized that the development of polycythemia chorea is associated with a reversible alteration in the corticobasal ganglia metabolism and disturbed dopaminergic function.

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“…A voxel-based morphometry (VBM) study comparing healthy controls and Parkinson's disease patients with and without depression found that depressed patients showed white matter loss in the right anterior cingulate cortex (ACC) bundle, orbitofrontal cortex, and left parietal lobe. Thus, depression in Parkinson's disease may represent a disconnection syndrome [9]. Indeed, diffusion tensor imaging (DTI) studies support this claim.…”

Section: Depression and Apathymentioning

confidence: 97%

“…This was especially prominent in the left caudate and right putamen. It is hypothesized that this may be because of DAT upregulation resulting in decreased dopaminergic transmission at the synapse [9]. A positron emission tomography (PET) study of the serotonin transporter demonstrated reduced serotonergic neurotransmission in the raphe nuclei and limbic structures in antidepressantnaive Parkinson's disease patients with depression.…”

Section: Depression and Apathymentioning

confidence: 99%

Affective disorders in Parkinsonʼs disease

Aminian¹,

Strafella²

2013

Current Opinion in Neurology

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Purpose of review-This review explores recent literature pertaining to affective disorders associated with Parkinson's disease.Recent findings-Nonmotor symptoms including affective disorders are becoming more widely recognized as complications of Parkinson's disease. As awareness of these symptoms increases, and new neuroimaging tools are developed and become more accessible, more studies are being conducted pertaining to behavioral complications in Parkinson's disease. The functional connectivity of the basal ganglia can predispose people with Parkinson's to develop affective disorders. Furthermore, dopaminergic treatments may exacerbate or trigger behavioral symptoms. It is now understood that changes associated with Parkinson's disease are widespread, affecting striatal and extrastriatal regions and resulting in alterations in gray matter, white matter, blood flow, metabolism, and dopaminergic and serotonergic function. Summary-Neuroimaging is advancing our knowledge of the mechanisms involved inParkinson's disease, and their role in the development of behavioral disorders. An increased understanding of these disorders may lead to the discovery of new therapeutic targets, or the identification of risk factors for the development of these disorders. If preventive therapies become available, identification of risk factors will be important for the identification and treatment of susceptible individuals.

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Higher dopamine transporter density in Parkinson’s disease patients with depression

Abstract: Our results suggest that in vivo DAT density is increased in dPD patients as compared to ndPD, suggesting that DAT is implicated in the pathophysiology of PD depression.

Cited by 63 publications

References 18 publications

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies

Reversible abnormal functional neuroimaging presentations in polycythemia vera with chorea

Affective disorders in Parkinsonʼs disease

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