Higher Dietary Se Intake Is Associated With the Risk of New-Onset Fracture: A National Longitudinal Study for 20 Years

Zhang, Yangchang; Ye, Mengliang; Zhao, Yong; Xiong, Yang; Shen, Shisi; Yu, Qiuhua; Lu, Yanjun; Shi, Zumin; Lei, Xun

doi:10.3389/fnut.2021.719147

Cited by 7 publications

(10 citation statements)

References 60 publications

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“…In conclusion, Se consumption was associated with BMD in postmenopausal women, and those with higher Se consumption were less likely to have osteoporosis. Based on this premise, our results expand the knowledge about the relationship between Se and the maintenance of bone health, although longitudinal investigations are necessary to clarify the role of Se in BMD and its consequences, since the results are still conflicting (10)(11)(12)(13)(14)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 65%

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Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women

et al. 2022

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BackgroundOsteoporosis is a skeletal disease characterized by reduced bone mineral density (BMD), which increases the risk of falls and fractures and reduces mobility. Some nutrients have a well-established role in maintaining bone health and preventing osteoporosis, while selenium (Se) has aroused interest in bone health possibly because of its anti-inflammatory and antioxidant capacity. The aim of this study was to evaluate the association between dietary Se consumption and BMD in postmenopausal women.Materials and methodsCross-sectional, observational, analytical study carried out with women in menopause for at least 12 months, aged ≥ 50 years. Sociodemographic, lifestyle, and clinical data variables were studied. BMD was assessed using Dual Energy X-ray Absorptiometry (DXA) and the participants classified as having normal BMD, osteopenia, or osteoporosis. Dietary consumption of Se was assessed by the food frequency questionnaire (FFQ) and classified into quartiles of consumption. Multivariate logistic regression with three fit models was applied to investigate the association of BMD with Se consumption quartiles. The significance level adopted for all tests was 5.0%.ResultsThe final sample consisted of 124 women aged in average 66.8 ± 6.1 years and with a time since menopause of 19.6 ± 8.8 years. According to the BMD, 41.9% of the women had osteopenia and 36.3% osteoporosis. The mean consumption of Se was 154.4 ± 88.7 μg/day. The highest consumption of Se was observed among women with normal BMD (51.9%), whereas lower consumption levels were found in 57.7% of women with osteopenia and in 60.0% of women with osteoporosis (p = 0.003). In the multivariate analysis, after adjusting for possible confounding variables, Se remained associated with the group of women with osteoporosis. Postmenopausal women in the highest quartile (≥94.0 μg/day) of Se consumption had an OR of 0.02 (95%CI: 0.001–0.41; p = 0.012) of having osteoporosis when compared with women in the lowest quartile.ConclusionSe consumption was associated with BMD and postmenopausal women with higher Se consumption were less likely to have osteoporosis.

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Section: Discussionmentioning

confidence: 65%

“…They observed that individuals with lower Se consumption had a higher prevalence of osteoporosis ( 13 ). On the other hand, a study carried out with Chinese adults of both sexes found a non-linear association between Se intake and fracture risk, demonstrating that higher Se consumption increased the risk for fractures ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women

et al. 2022

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“…Although several confounding factors were considered in this study, unfortunately, detailed information on hormonal status is lacking [207]. Zhang et al used data from 17,150 participants from the China Health and Nutrition Survey, in which the selfreported history of fractures showed a non-linear association with selenium intake [208]. Recently, Wu et al analyzed the data of 2983 adults in the National Health and Nutrition Examination Survey (NHANES) 2013-2014 [50] and observed that a higher selenium level, measured in plasma and diet, correlated with a lower bone mineral density and a decreased FRAX score, which represents the 10-year fracture risk [50].…”

Section: Association Of Selenium Intake Levels With Bone Health: Obse...mentioning

confidence: 99%

“…Although there are studies showing non-significant results between selenium and bone health [47,49,194,198,199,202,205], a positive correlation was observed between selenium and bone health, showing a positive relationship between selenium and bone mineral density [48,50,[195][196][197]200,203,204,207]and a reduction in the risk of osteoporotic fracture [50,196,201,206,208]. The limitations of these observational studies include the fact that not all, but some, were conducted with sample sizes too small to achieve statistically valid results.…”

Section: Association Of Selenium Intake Levels With Bone Health: Obse...mentioning

confidence: 99%

The Effects of Selenium on Bone Health: From Element to Therapeutics

et al. 2022

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Osteoporosis, characterized by low bone mass and a disruption of bone microarchitecture, is traditionally treated using drugs or lifestyle modifications. Recently, several preclinical and clinical studies have investigated the effects of selenium on bone health, although the results are controversial. Selenium, an important trace element, is required for selenoprotein synthesis and acts crucially for proper growth and skeletal development. However, the intake of an optimum amount of selenium is critical, as both selenium deficiency and toxicity are hazardous for health. In this review, we have systematically analyzed the existing literature in this field to determine whether dietary or serum selenium concentrations are associated with bone health. In addition, the mode of administration of selenium as a supplement for treating bone disease is important. We have also highlighted the importance of using green-synthesized selenium nanoparticles as therapeutics for bone disease. Novel nanobiotechnology will be a bridgehead for clinical applications of trace elements and natural products.

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“…Therefore, identifying risk factors seems requisite to suppress the high incidence in the aged. Previous studies have disclosed that genetics, obesity, unhealthy diet can increase the risk of OA ( 5 – 7 ). Among these risk factors, the role of trace element selenium in the onset of OA is gradually noted.…”

Section: Introductionmentioning

confidence: 99%

A national cross-sectional analysis of selenium intake and risk of osteoarthritis: NHANES 2003–2016

Deng

Tan

2023

Front. Public Health

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BackgroundThe association between dietary selenium intake and arthritis, rheumatoid arthritis (RA), and osteoarthritis (OA) is inconsistent in previous studies and remain unclear. To investigate their relationship, this study was performed.MethodsData from the National Health and Nutrition Examination Survey (2003–2016) were downloaded and further analyzed. Dietary Se intake was classified according to quartiles with quartile 1 (Q1) having the lowest intake and quartile 4 (Q4) having the highest intake. Weighted logistic regression was used to investigate the association between dietary selenium intake and arthritis, RA, and OA. Subgroup analyses were performed to verify the findings. To further examine the non-linear relationship between dietary selenium intake and OA, restricted cubic spline (RCS) was adopted.ResultsIn the crude model, the highest level of dietary selenium intake was siginificantly associated with decreased risks of arthritis (OR: 0.40, 95% CI: 0.37, 0.44) and rheumatoid arthritis (OR: 0.47, 95% CI: 0.40, 0.54), respectively. In the fully adjusted model, dietary selenium intake was not associated with risk of arthritis and RA (all P > 0.05). Conversely, the risk of OA was noted for participants with higher selenium intake (odds ratio of quartile 4 = 1.33, 95% CI = 1.07–1.65, P < 0.05). In the subgroup analyses, participants with diabetes had a higher risk of OA when ingested high selenium levels than those without diabetes (P < 0.001). The results of RCS showed that significant overall trends were found between dietary selenium intake and osteoarthritis (P for overall < 0.05). However, non-linear association was not detected in this association (P for non-linear > 0.05).ConclusionUsing data from NHANES, this study discloses that high dietary selenium intake might be associated with risk of OA. However, the generalization of conclusion needs further examination because of the limitation of dietary questionnaire survey.

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Higher Dietary Se Intake Is Associated With the Risk of New-Onset Fracture: A National Longitudinal Study for 20 Years

Cited by 7 publications

References 60 publications

Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women

Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women

The Effects of Selenium on Bone Health: From Element to Therapeutics

A national cross-sectional analysis of selenium intake and risk of osteoarthritis: NHANES 2003–2016

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