Higher dietary acid load is associated with a higher prevalence of frailty, particularly slowness/weakness and low physical activity, in elderly Japanese women

Kataya, Yuki; Murakami, Kentaro; Kobayashi, Satomi; Suga, Hitomi; Sasaki, Satoshi

doi:10.1007/s00394-017-1449-4

Cited by 16 publications

(16 citation statements)

References 58 publications

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“…In support of this hypothesis, a randomized controlled trial with 162 healthy men and women aged 50 and older found that bicarbonate supplementation improved leg press power in women [120]. A cross-sectional study on 2176 Japanese women aged 65-94 years found that a higher dietary acid load was positively associated with frailty [121], but once again did not explicitly demonstrate that an alkaline diet is necessarily superior. Further research is needed to conclude whether fruits and vegetables exert their effects through their alkaline properties, antioxidant properties, some other component, or if intake is simply a marker of a healthy diet.…”

Section: Fruits and Vegetablesmentioning

confidence: 99%

Nutrition and Sarcopenia—What Do We Know?

2020

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Muscle health is important for the functionality and independence of older adults, and certain nutrients as well as dietary patterns have been shown to offer protective effects against declines in strength and function associated with aging. In this paper, micronutrients, macronutrients, and food groups have been reviewed, along with their studied effects on the prevalence and incidence of sarcopenia, as well as their ability to preserve muscle mass and optimize physical performance. Randomized controlled trials appear to suggest a critical role for dietary intake of protein in preventing sarcopenia and muscle loss, although the optimal dose and type of protein is unknown. There are some promising data regarding the role of vitamin D and sarcopenia, but it is unclear whether the dose, frequency of dose, or length of treatment impacts the efficacy of vitamin D on improving muscle mass or function. Selenium, magnesium, and omega 3 fatty acids have been studied as supplements in clinical trials and in the diet, and they appear to demonstrate a potential association with physical activity and muscle performance in older individuals. Following the Mediterranean diet and higher consumption of fruits and vegetables have been associated with improved physical performance and protection against muscle wasting, sarcopenia, and frailty.

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Section: Fruits and Vegetablesmentioning

confidence: 99%

Nutrition and Sarcopenia—What Do We Know?

2020

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“…Regardless, acidosis promotes degradation of muscle protein [198] . A high estimated dietary acid load has been associated with frailty in elderly Japanese women [199] Recovery from lactic acidosis is mediated by MCTs, NBCs, and NHEs [200] , while CAIII specifically has been shown to plays a role in defense from muscle fatigue [201] .…”

Section: Applications By Organ Systemmentioning

confidence: 99%

The therapeutic importance of acid-base balance

Quade

Parker

Occhipinti

2021

Biochemical Pharmacology

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Baking soda and vinegar have been used as home remedies for generations and today we are only a mouse-click away from claims that baking soda, lemon juice, and apple cider vinegar are miracles cures for everything from cancer to COVID-19. Despite these specious claims, the therapeutic value of controlling acid-base balance is indisputable and is the basis of Food and Drug Administration-approved treatments for constipation, epilepsy, metabolic acidosis, and peptic ulcers. In this narrative review, we present evidence in support of the current and potential therapeutic value of countering local and systemic acid-base imbalances, several of which do in fact involve the administration of baking soda (sodium bicarbonate). Furthermore, we discuss the side effects of pharmaceuticals on acid-base balance as well as the influence of acid-base status on pharmacokinetic properties of drugs. Our review considers all major organs systems as well as information relevant to several clinical specialties such as anesthesiology, infectious disease, oncology, dentistry, and surgery.

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“…Despite this, our mean PRAL was of a similar magnitude as found in the literature. For women mean PRAL values of 1.9 ± 10.6, 4.9 ± 12.3, –7.2 ± 12.4, –5.5 ± 12 and 1.0 ± 14 and for men mean values of 3.3 (IQR –1.9 – 9.3), –4.5 ± 12.2, –3.6 ± 12 and 3.9 ± 14 have been described. Although in men, protein, potassium and phosphorus intake decreased, mean PRAL values did not differ significantly between the two assessments.…”

Section: Discussionmentioning

confidence: 89%

“…Several other prospective studies compared a single estimated dietary intake and corresponding PRAL values with outcomes over time . A link between higher diet‐induced acid load with increased risk of cardiovascular diseases, type 2 diabetes and a negative effect between dietary acid load and bone health in elderly men and elderly women has been described. To make reliable long‐term conclusions, PRAL generated at baseline must reflect the continuing acid–base balance over time, that is, showing acceptable stability.…”

Section: Introductionmentioning

confidence: 99%