Higher Depression Scores in Patients with Drug-Resistant Schizophrenia

Panov, Georgi

doi:10.31083/j.jin2105126

Cited by 6 publications

(4 citation statements)

References 52 publications

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“…In addition, the connectivity matrices proved to be suitable for differentiating between patients with MDE and HC with fairly high precision levels. Further integration of these results with clinical measures, structural and diagnostic task-related functional MRI on the level of multivariate analysis may outline new approaches and criteria to the definition of mental disorders [ 70 , 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode

Stoyanov

Khorev

Paunova

et al. 2022

IJERPH

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Aim: This study aims to develop new approaches to characterize brain networks to potentially contribute to a better understanding of mechanisms involved in depression. Method and subjects: We recruited 90 subjects: 49 healthy controls (HC) and 41 patients with a major depressive episode (MDE). All subjects underwent clinical evaluation and functional resting-state MRI. The data were processed investigating functional connectivity network measures across the two groups using Brain Connectivity Toolbox. The statistical inferences were developed at a functional network level, using a false discovery rate method. Linear discriminant analysis was used to differentiate between the two groups. Results and discussion: Significant differences in functional connectivity (FC) between depressed patients vs. healthy controls was demonstrated, with brain regions including the lingual gyrus, cerebellum, midcingulate cortex and thalamus more prominent in healthy subjects as compared to depression where the orbitofrontal cortex emerged as a key node. Linear discriminant analysis demonstrated that full-connectivity matrices were the most precise in differentiating between depression vs. health subjects. Conclusion: The study provides supportive evidence for impaired functional connectivity networks in MDE patients.

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Section: Discussionmentioning

confidence: 99%

Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode

Stoyanov

Khorev

Paunova

et al. 2022

IJERPH

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“…The same group of patients were also analyzed with regard to other clinical indicators such as depressive complaints, dissociative symptoms, lateralization of brain processes, the effect of the administration of the first antipsychotic medication, and the genderassociated role in patients with schizophrenia (67)(68)(69)(70)(71)(72)(73).…”

Section: Methodsmentioning

confidence: 99%

Obsessive-compulsive symptoms in patient with schizophrenia: The influence of disorganized symptoms, duration of schizophrenia, and drug resistance

Panov

Panova

2023

Front. Psychiatry

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BackgroundSchizophrenia is a chronic mental disorder with a many-faced clinical presentation. Obsessive–compulsive symptoms are often part of it. The characteristics of the clinical picture and the course of schizophrenia are factors related to both the resistance and the manifestation of obsessive–compulsive symptoms. Our study aims to establish the relationship between the peculiarities of the schizophrenia process and the influence of resistance on the expression of obsessive–compulsive symptoms.MethodsA study was conducted on 105 patients with schizophrenia. Of them, 39 are men and 66 are women. The evaluation of the effectiveness of the treatment showed that 45 were resistant to the applied therapy, while the remaining 60 responded. Clinical assessment of patients was performed using the Positive and Negative Syndrome Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS). Assessment of obsessive–compulsive symptoms (OCS) was conducted with the Dimensional obsessive–compulsive symptoms scale (DOCS).ResultsIn 34% of all patients, we found clinically expressed obsessive–compulsive symptoms. In 40% of the patients with resistance, we found clinically expressed obsessive–compulsive symptoms, which are within the range of moderately expressed. In 30% of the patients in clinical remission, we found obsessive–compulsive symptoms, but mildly expressed. We found a statistically significant relationship between the severity of OCS and the disorganized symptoms and the duration of the schizophrenia process. No differences were found in the expression of OCS in patients of both sexes.ConclusionWe registered both an increased frequency and an increased expression of obsessive–compulsive symptoms in patients with resistant schizophrenia. These symptoms were positively associated with disorganized symptoms and duration of schizophrenia. No relationship was established with the positive, negative symptoms, as well as with the gender distribution.

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“…The same cohort of patients was also investigated concerning other clinical characteristics such as depressive complaints, obsessive-compulsive and dissociative symptoms, lateralization of brain processes, the effect of the administration of the first antipsychotic medication and the gender-associated role in patients with schizophrenia [68][69][70][71][72][73][74][75].…”

Section: Statistical Analysesmentioning

confidence: 99%

Cognition in Patients with Schizophrenia: Interplay between Working Memory, Disorganized Symptoms, Dissociation, and the Onset and Duration of Psychosis, as Well as Resistance to Treatment

Panov,

Dyulgerova,

Panova

2023

Biomedicines

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Schizophrenia is traditionally associated with the presence of psychotic symptoms. In addition to these, cognitive symptoms precede them and are present during the entire course of the schizophrenia process. The present study aims to establish the relationship between working memory (short-term memory and attention), the features of the clinical picture, and the course of the schizophrenic process, gender distribution and resistance to treatment. Methods: In total, 105 patients with schizophrenia were observed. Of these, 66 were women and 39 men. Clinical status was assessed using the Positive and Negative Syndrome Scale (PANSS), Brief Psychiatric Rating Scale (BPRS), Dimensional Obsessive–Compulsive Symptom Scale (DOCS), scale for dissociative experiences (DES) and Hamilton Depression Rating Scale (HAM-D)—cognitive functions using the Luria 10-word test with fixation assessment, reproduction and attention analysis. The clinical evaluation of resistance to the treatment showed that 45 patients were resistant to the ongoing medical treatment and the remaining 60 had an effect from the therapy. Results: Our study showed that, in most patients, we found disorders of working memory and attention. In 69.82% of the patients, we found problems with fixation; in 38.1%, problems with reproduction; and in 62.86%, attention disorders. Conducting a regression analysis showed that memory and attention disorders were mainly related to the highly disorganized symptoms scale, the duration of the schizophrenic process and the dissociation scale. It was found that there was a weaker but significant association between the age of onset of schizophrenia and negative symptoms. In the patients with resistant schizophrenia, much greater violations of the studied parameters working memory and attention were found compared to the patients with an effect from the treatment. Conclusion: Impairments in working memory and attention are severely affected in the majority of patients with schizophrenia. Their involvement is most significant in patients with resistance to therapy. Factors associated with the highest degree of memory and attention impairment were disorganized symptoms, duration of schizophrenia, dissociative symptoms and, to a lesser extent, onset of illness. This analysis gives us the right to consider that the early and systematic analysis of cognition is a reliable marker for tracking both clinical dynamics and the effect of treatment.

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Higher Depression Scores in Patients with Drug-Resistant Schizophrenia

Cited by 6 publications

References 52 publications

Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode

Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode

Obsessive-compulsive symptoms in patient with schizophrenia: The influence of disorganized symptoms, duration of schizophrenia, and drug resistance

Cognition in Patients with Schizophrenia: Interplay between Working Memory, Disorganized Symptoms, Dissociation, and the Onset and Duration of Psychosis, as Well as Resistance to Treatment

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