Higher complication risk of totally implantable venous access port systems in patients with advanced cancer – a single institution retrospective analysis

Abstract

Our study indicates that totally implantable port systems yield a higher risk of complications in terminally ill patients. Further investigation should be carefully conducted to compare outcomes of various central venous access devices in patients with advanced cancer and to develop preventive strategies against catheter failure.

Comparing normal saline versus diluted heparin to lock non-valved totally implantable venous access devices in cancer patients: a randomised, non-inferiority, open trial

“…The incidence rate in the present study for laboratoryconfirmed BSI of 0.03/1000 and 0.10/1000 catheter days in the NS and heparin groups, respectively, is lower than that in the published studies [23][24][25]. Furthermore, only three TIVADs (0.38%) were prematurely removed due to infection, much less than recently reported rates (3.5%-8.9%) [23,25,26].…”

“…Furthermore, only three TIVADs (0.38%) were prematurely removed due to infection, much less than recently reported rates (3.5%-8.9%) [23,25,26]. This may be due to our strict sterile insertion procedure and again on the availability, skill, and training mission of the institution's multidisciplinary venous access team.…”

Increased rates of local complication of central venous catheters in the targeted anticancer therapy era: a 2-year retrospective analysis

“…Increasing age, male gender, open-ended catheters, and hematogenous malignancy were significant independent risk factors for the failure of totally implantable venous access devices in a study by Hsieh et al [14]. Other studies reported that the port-a-cath-related infection was significantly associated with advanced cancer stage (hazard ratio (HR)=6.5, p= 0.077), administration of palliative care immediately after implantation (HR=7.3, 95 % CI=1.2-46.0), and body surface area >1.71 m 2 (HR=3.4, p=0.029) [15][16][17].…”

Totally implantable venous access port systems and associated complications: A single-institution retrospective analysis of 2,996 breast cancer patients

“…Several studies on cancer patients have investigated potential risk factors for TIVAPS-related complications, with somewhat conflicting results (3,(7)(8)(9)(10). The reported experience with TIVAPS in breast cancer patients has been limited to studies including a relatively limited number of patients.…”