Higher body mass index is associated with incident diabetes and chronic kidney disease independent of genetic confounding

Xu, Hong; Kuja‐Halkola, Ralf; Chen, Xu; Magnusson, Patrik K. E.; Svensson, Per; Carrero, Juan-Jesús

doi:10.1016/j.kint.2018.12.019

Cited by 30 publications

(18 citation statements)

References 47 publications

(57 reference statements)

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“…Various population-based studies have described an association between higher BMI and the development of CKD [31][32][33][34] as well as a more rapid decline of kidney function. 35 Consistently, epidemiologic studies have indicated that a higher BMI is an independent estimator for future ESKD.…”

Section: Discussionmentioning

confidence: 99%

The Triglyceride-Glucose Index and Obesity-Related Risk of End-Stage Kidney Disease in Austrian Adults

Fritz

Brozek²,

Concin³

et al. 2021

JAMA Netw Open

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IMPORTANCE It is unknown whether the triglyceride-glucose (TyG) index as a measure of insulin resistance is associated with the risk of developing end-stage kidney disease (ESKD). Because individuals who are overweight or obese often develop insulin resistance, mediation of the association between body mass index (BMI) and ESKD risk through the TyG index seems plausible but has not been investigated. OBJECTIVE To evaluate whether the TyG index is associated with ESKD risk and, if so, to what extent the TyG index mediates the association between BMI and ESKD. DESIGN, SETTING, AND PARTICIPANTS A total of 176 420 individuals were recruited during routine health examinations to participate in the Austrian Vorarlberg Health Monitoring and Promotion Program (VHM&PP), a prospective, population-based cohort study with participant

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Section: Discussionmentioning

confidence: 99%

The Triglyceride-Glucose Index and Obesity-Related Risk of End-Stage Kidney Disease in Austrian Adults

Fritz

Brozek²,

Concin³

et al. 2021

JAMA Netw Open

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“…Accordingly, the imbalance between production and excretion of uric acid contributes to hyperuricemia [ 5 ]. Growing evidence has shown that higher body mass index (BMI) increases the risks of renal impairment, leading to a decrease in uric acid clearance [ 6 , 7 ]. Furthermore, higher BMI can disrupt the glucose and insulin metabolism [ 8 ], which may subsequently impair the renal handing of uric acid and alter SUA concentration [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Independent and joint associations of body mass index, waist circumference, waist-height ratio and their changes with risks of hyperuricemia in middle-aged and older Chinese individuals: a population-based nationwide cohort study

Zhou

et al. 2021

Nutr Metab (Lond)

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Background Previous reports regarding the predictive power of adiposity indices remain inconsistent, and longitudinal studies on this top are limited. The associations of hyperuricemia risk with changes in obesity status, as well as the joint effects of baseline adiposity indices and body adiposity change on hyperuricemia risk are not fully elucidated. This study aimed to explore the independent and joint associations of baseline adiposity indicators and body adiposity change with hyperuricemia risk among middle-aged and older population in China. Methods A total of 2895 participants aged ≥ 45 years from the baseline survey of the China Health and Retirement Longitudinal Study were followed up for 4 years. Anthropometric parameters (weight, height, and waist circumference) and serum uric acid were obtained using standard devices. Adjusted odds ratio and 95% confidential interval were calculated to estimate the associations between predictor variables and hyperuricemia risk using multivariate logistic regression. Results Of the 2895 participants, 293 (10.12%) cases of hyperuricemia were identified. Increased baseline body mass index (BMI), waist circumference, and waist-height ratio (WHtR) were significantly associated with higher risks of hyperuricemia. A slightly greater but non-significant area under the curve value was observed for waist circumference (0.622) than for BMI (0.611) and WHtR (0.614) (P = 0.447). Compared to subjects with stable adiposity status, participants with weight loss of ≥ 4 kg or waist circumference loss of ≥ 6 cm had a 56% or 55% lower risk of hyperuricemia, and those with weight gain of > 4 kg had a 1.62-fold higher risk of hyperuricemia. Compared to those without obesity, participants with incident or persistent obesity were more likely to develop hyperuricemia. Additionally, regardless of stable or increased weight/waist circumference during follow-up, individuals with obesity at baseline had a higher risk of incident hyperuricemia. Conclusion This study demonstrates that BMI, waist circumference, and WHtR equally predict the development of hyperuricemia, and weight loss and waist circumference reduction are favorable in preventing hyperuricemia.

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“…However, to date, the relationship of BMI with acid-base status has been examined to only a limited extent. 13 , 22 Given the independent risk for CKD associated with obesity and metabolic syndrome, 25 , 26 it is important to clarify the extent to which obesity predisposes patients to developing low bicarbonate levels. This information may suggest appropriate clinical interventions to reduce the already high burden of disease among overweight and obese individuals.…”

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confidence: 99%

Obesity and the Risk of Low Bicarbonate: A Cohort Study

Lambert

Abramowitz

2021

Kidney Medicine

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Higher body mass index is associated with incident diabetes and chronic kidney disease independent of genetic confounding

Cited by 30 publications

References 47 publications

The Triglyceride-Glucose Index and Obesity-Related Risk of End-Stage Kidney Disease in Austrian Adults

The Triglyceride-Glucose Index and Obesity-Related Risk of End-Stage Kidney Disease in Austrian Adults

Independent and joint associations of body mass index, waist circumference, waist-height ratio and their changes with risks of hyperuricemia in middle-aged and older Chinese individuals: a population-based nationwide cohort study

Obesity and the Risk of Low Bicarbonate: A Cohort Study

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