Higher BDNF plasma levels are associated with a normalization of memory dysfunctions during an antidepressant treatment

Engelmann, Jan; Wagner, Stefanie; Wollschläger, Daniel; Kaaden, Sabine; Schlicht, Konrad Friedrich; Dreimüller, Nadine; Braus, Dieter F.; Müller, Marianne B.; Tüscher, Oliver; Frieling, Helge; Tadić, André; Lieb, Klaus

doi:10.1007/s00406-019-01006-z

Cited by 12 publications

(6 citation statements)

References 58 publications

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“…Also, self-reported memory complaints, assessed by different questionnaires in which participants report every-day subjective memory function, were also associated with anxiety and depression symptomatology in healthy subjects without objective memory impairment ( Balash et al, 2013 ). Regarding declarative verbal memory, studies which objectively assessed this type of memory have found an association between declarative memory impairment and mood disorders ( Biringer et al, 2007 ; Chepenik et al, 2012 ; Engelmann et al, 2020 ). In long-COVID population, many studies assessing the relevance of clinical symptoms have found an association between subjective memory complaints and depressive feelings ( Titze de Almeida et al, 2022 ) or the presence of anxiety and depression ( Almeria et al, 2020 ; Cysique et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID

et al. 2023

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Background and purposeThe coronavirus disease 2019 (COVID-19) has been associated with olfactory dysfunction. The persistent symptoms of anosmia or hyposmia were associated in previous studies with the development of memory impairment and mood disturbances. We aimed to investigate the association between the chronicity of reported olfactory dysfunction and subjective and objective cognitive performance in long-COVID patients and to explore whether their emotional symptoms are related to their cognition.MethodsOne hundred twenty-eight long-COVID participants were recruited. Reported symptomatology, subjective memory complaints, anxiety and depression symptomatology, and trait-anxiety were assessed. Subjective memory complaints and mood disturbances were compared among groups of participants with olfactory dysfunction as an acute (AOD), persistent (POD), or nonexistent (NOD) symptom. Seventy-six of the volunteers also participated in a face-to-face session to assess their objective performance on tests of general cognitive function and verbal declarative memory. Objective cognitive performance and mood disturbances were compared among the AOD, POD, and NOD groups.ResultsThe subjective memory complaints and the anxiety and depression symptoms were similar among the groups, but the score in general cognitive function was lower in the participants with symptoms of acute olfactory dysfunction than in those with no olfactory symptoms at any time. Participants’ memory complaints were positively related to their emotional symptoms. The relationship between depressive symptomatology and memory complaints interacted with the olfactory dysfunction, as it only occurred in the participants without symptoms of olfactory dysfunction. Depressive symptomatology and acute olfactory symptoms were negatively associated with general cognitive function and delayed memory performance. The months elapsed from diagnosis to assessment also predicted delayed memory performance. Anxious symptomatology was negatively associated with the immediate ability to recall verbal information in participants who did not present olfactory dysfunction in the acute phase of the infection.ConclusionOlfactory dysfunction in the acute phase of the infection by COVID-19 is related to cognitive deficits in objective tests, and mood disturbances are associated with self-reported and objective memory. These findings may contribute to further understanding the neuropsychological and emotional aspects of long-COVID.

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Section: Introductionmentioning

confidence: 99%

Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID

et al. 2023

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“…However, investigations on epigenetic changes in BDNF have been described in individuals with psychiatric disorders and neurodegenerative diseases, including depression, Huntington's disease, and schizophrenia (Ikegame et al, 2013 ; Zheleznyakova et al, 2016 ; Di Carlo et al, 2019 ; Gutierrez et al, 2020 ). Engelmann et al ( 2020 ) focused on the promoter region of exon IV of the BDNF gene, however, they have investigated a different sequence than the one analyzed in this study. They found no association between methylation status in the BDNF exon IV promoter and memory test performance in depressive patients on antidepressant therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies show that BDNF methylation CpG regions have been linked to cognitive deficits and psychiatric diseases (Grayson and Guidotti, 2013;Azman and Zakaria, 2022). Moreover, differences are observed in the methylation level at CpG sites of BNDF promoter IV on poor performance in learning and memory tasks such as the Brief Visuospatial Memory Test-Revised (BVMT-R) (Engelmann et al, 2020) and the Rey Complex Figure Test (RCFT) in women with major depressive disorders (MDDs) (Ferrer et al, 2019). There is increasing evidence for the involvement of epigenetic regulation of the BDNF in cognition.…”

Section: Introductionmentioning

confidence: 99%

Methylation of BDNF gene in association with episodic memory in women

et al. 2023

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Brain-derived neurotrophic factor (BDNF) gene regulation plays an important role in long-term memory formation, and the DNA methylation (DNAm) level of BDNF promoters has been associated with episodic memory deficits. Our aim was to explore the association between DNAm levels in BDNF promoter IV with verbal learning and memory performance in healthy women. We conducted a cross-sectional study by recruiting 53 individuals. Episodic memory was assessed by using the Rey Auditory Verbal Learning Test (RAVLT). Clinical interviews, RAVLT, and blood sample collection were assessed in all participants. DNAm was measured on DNA from whole peripheral blood using pyrosequencing. According to generalized linear model (GzLM) analyses, cytosine guanine dinucleotide (CpG) site 5 showed significant associations between learning capacity (LC, p < 0.035), that is, every 1% of DNA methylation at CpG site 5 results in a 0.068 reduction in verbal learning performance. To the best of our knowledge, the current study is the first to show that BDNF DNAm plays an important role in episodic memory.

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“…In our study, we obtained significant associations between serum BDNF levels and MDD severity, precipitating factors, executive functions` disruption (performance of TMT-B and RAVLT immediate recall), and all subdomains of functioning. Previous studies in MDD patients have found correlations between BDNF levels and the presence of melancholic features and psychomotor retardation ( 59 ), DE severity ( 36 , 60 ) and duration ( 60 ), and cognitive decline during performances of TMT-B ( 61 ) and verbal delayed recall ( 62 ). Nevertheless, one study evidenced no correlations between patients’ plasma BDNF levels and cognitive functioning ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of the Combination of Serum Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor-1 for Major Depressive Disorder Diagnosis and Treatment Efficacy

Troyan

2020

Front. Psychiatry

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Background: Last decades of psychiatric investigations have been marked by a search for biological markers that can clarify etiology and pathogenesis, confirm the diagnosis, screen individuals at risk, define the severity, and predict the course of mental disorders. In our study, we aimed to evaluate if BDNF and IGF-1 serum concentrations separately and in combination might be used as biomarkers for major depressive disorder (MDD) diagnosis and treatment efficacy and to evaluate the relationships among those proteins and clinical parameters of MDD. Methods: Forty-one MDD patients (according to DSM-5) and 32 healthy controls (HC) were included in this study. BDNF and IGF-1 serum concentrations, psychopathological (MADRS, CGI) and neuropsychological parameters (PDQ-5, RAVLT, TMT-B, DSST), functioning according to Sheehan Disability Scale were analyzed in all subjects at admission and 30 MDD patients after 8 weeks of vortioxetine treatment. Correlational analyses were performed to explore relationships between BDNF and IGF-1 and clinical characteristics. AUC-ROCs were calculated to determine if the value of serum BDNF and IGF-1 levels could serve for MDD diagnosis. Results: MDD patients had significantly lower serum BDNF (727.6 ± 87.9 pg/ml vs. 853.0 ± 93.9 pg/ml) and higher serum IGF-1 levels (289.15 ± 125.3 ng/ml vs. 170.2 ± 58.2 ng/ ml) compared to HC. Significant correlations were obtained between BDNF levels and MDD status, depressive episode (DE) severity, precipitating factors, executive functions disruption (TMT-B, RAVLT immediate recall scores) and all subdomains of functioning. As for IGF-1, correlations were found between IGF-1 level and MDD status, DE severity, number and duration of DE, parameters of subjective and objective cognitive functioning (PDQ-5, RAVLT, TMT-B, DSST scores), and all subdomains of functioning. The associations between IGF-1 concentrations and cognitive tests' performance were stronger than those of BDNF. Separately both BDNF and IGF-1 demonstrated good

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Higher BDNF plasma levels are associated with a normalization of memory dysfunctions during an antidepressant treatment

Cited by 12 publications

References 58 publications

Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID

Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID

Methylation of BDNF gene in association with episodic memory in women

The Diagnostic Value of the Combination of Serum Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor-1 for Major Depressive Disorder Diagnosis and Treatment Efficacy

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