High-yielding regioselective synthesis of p-quinone fused 5-substituted-1,4-benzodiazepine scaffolds via Pictet–Spengler type cycloannulation

Abstract

We designed a robust protocol to access p-quinone fused 5-substituted-1,4-benzodiazepine scaffolds, a new molecular hybrid, through InCl3 mediated Pictet–Spengler type cycloannulation of 2-amino-3-arylamino-p-quinone and aldehydes.