High Yielding, One-Pot Synthesis of Bis(1H-indazol-1-yl)methane Catalyzed by 3d-Metal Salts

Abstract

Synthetic access to poly(indazolyl)methanes has limited their study despite their structural similarity to the highly investigated chelating poly(pyrazolyl)methanes and their potentially important indazole moiety. Herein is presented a high yielding, one-pot synthesis for the 3d-metal catalyzed formation of bis(1H-indazol-1-yl)methane from 1H-indazole utilizing dimethylsulfoxide as the methylene source. Complete characterization of bis(1H-indazol-1-yl)methane is given with 1H and 13C NMR, UV/Vis, FTIR, high resolution mass spectrometry and for the first time, single crystal X-ray diffraction. This simple, inexpensive pathway to yield exclusively bis(1H-indazol-1-yl)methane provides synthetic access to further investigate the coordination and potential applications of the family of bis(indazolyl)methanes.

Template Synthesis of Ni(II) and Zn(II) Complexes Derived from N2O2 Donor Symmetrical Tetradentate Ligands System: Comparative Antioxidant, Xanthine inhibitory, and Computational Studies

“…The ligand and complex will be formed in this case in a one-pot reaction system. This route has the advantage of producing a high yield while saving time (Kong et al, 2019;Lind et al, 2022). Yet, one disadvantage of this strategy is that the byproduct educts of the in-situ reaction may occasionally alter the composition of the final product (Elsebach et al, 2020).…”