High‐Yield Synthesis of Multifunctional Tellurium Nanorods to Achieve Simultaneous Chemo‐Photothermal Combination Cancer Therapy

Abstract

Tellurium (Te) is an important semiconductor material with low band‐gap energy, which has attracted considerable attention in recent years, due to its special chemical and physical properties and wide potential in electrochemistry, optoelectronics, and biological fields. This study demonstrates a facile and high‐yield synthesis strategy of Te nanorods (PTW‐TeNRs) decorated by polysaccharide–protein complex, which can achieve simultaneous chemo‐photothermal combination therapy against cancers. PTW‐TeNRs alone possess high stability under physiological conditions, potent anticancer activities through induction of reactive oxygen species overproduction, and high selectivity among tumor and normal cells. More importantly, they exhibit strong near‐infrared (NIR) absorbance and good photothermal conversion ability from NIR light to heat energy. Furthermore, in combination with NIR laser irradiation, PTW‐TeNRs exhibit excellent chemo‐photothermal efficiency and low toxicity as evidenced by highly efficient tumor ablation ability, but show no obvious histological damage to the major organs. Taken together, this study provides a valid tactic for facile synthesis of multifunctional tellurium nanorods for efficient and combinational cancer therapy.

Designing Bioinspired 2D MoSe2 Nanosheet for Efficient Photothermal‐Triggered Cancer Immunotherapy with Reprogramming Tumor‐Associated Macrophages

“…Interestingly, studies also found that, PEG or liposomes decoration of nanomaterials exhibited higher accelerated clearance during blood circulation 8b,9. Therefore, in most preclinical studies, photothermal agents have been administered via intratumoral injection to avoid the dissatisfactory hemocompatibility and blood clearance . Hence, it is urgent to find ways to improve the hemocompatibility of photothermal agents, and to enhance their blood circulation.…”

Solar‐Inspired Water Purification Based on Emerging 2D Materials: Status and Challenges

“…The research work shows its wider application in electronics, optoelectronics, and biomedicine field . The photothermal effect of Te nanomaterials is also found and has been utilized for photothermal cancer therapy . The bandgap of Te is only 0.35 eV, which endows a broadband absorption and efficient photothermal conversion .…”

“…[206][207][208][209] The photothermal effect of Te nanomaterials is also found and has been utilized for photothermal cancer therapy. [210,211] The bandgap of Te is only 0.35 eV, which endows a broadband absorption and efficient photothermal conversion. [210] Moreover, its stable photothermal performance can also be observed.…”

“…[210,211] The bandgap of Te is only 0.35 eV, which endows a broadband absorption and efficient photothermal conversion. [210] Moreover, its stable photothermal performance can also be observed. [211] Interestingly, the photothermal effect was also found in several Te-related compounds, for instance, the TePt [212] and CuTe, [213] which may be related to the intrinsic photothermal nature of Te.…”

Modus Operandi of Simultaneous Covering Synthesis from Precursor Heterogeneity for Shelled Nanorods for Multipotent Cancer Theranostics

“…Based on published reports, TeNRs have attracted significant interest for biomedical applications owing to their low cytotoxicity and excellent photothermal conversion efficiency. [36][37][38] However, the poor colloidal stability of TeNRs during long-term storage and in physiological media have presented obstacles that prevent their substitution for conventional noble metal nanomaterials. [39][40][41] In addition to the development of a simple and attractive synthesis method using the heterogeneous precursor platform, the BTCNs overcame the limitations of TeNRs.…”