High-yield synthesis of bioactive ethyl cinnamate by enzymatic esterification of cinnamic acid

Lipase mediated synthesis of rutin fatty ester: Study of its process parameters and solvent polarity

“…5B). However, further increase in the molar ratio decreased the ester formation to 14.74%.This is consistent with the results obtained by Wang et al (2013), who noted that increasing the molar ratio increased ethyl cinnamate production till certain point, after which further increase in acyl donor concentration decreased the production significantly. Though Kontogianni et al (2001) suggested no inhibition by higher concentrations of decanoic acid during esterification with naringin, some recent studies suggest a possibility of substrate inhibition of Candida antartica lipase at higher acyl donor concentrations (Zhu et al, 2014).…”

“…If the choice of reaction medium is a hydrophilic solvent, the importance of water becomes more crucial, in view of the intense competition for water prevailing between enzyme molecules and solvent system (Halling, 1984). Significant number of reports on the effect of reaction medium hydrophobicity and the water activity on esterification of several phenolic acids with different acyl donors are available (Humeau, Girardin, Coulon, & Miclo, 1995;Karboune, Safari, Lue, Yeboah, & Kermasha, 2005;Roby et al, 2015;Wang, Zhang, Zhang, Chen, & Zhi, 2013).…”

Efficient kinetic resolution of (RS)‐1‐phenylethanol by a mycelium‐bound lipase from a wild‐type Aspergillus oryzae strain

“…This might be possible because the presence of appropriate water in the reaction system satisfied the requirement of the enzyme for holding an essential water layer to perform its catalytic functions properly. However, the low water activities provided insufficient water for the buildup of the essential water shell for enzyme, and the high water activities implied excessive water and thereby the increasing competition of water for the acyl–enzyme intermediate . The ee p values were not affected by the water activity of reaction system, all of which were >99%.…”

Synthesis and Characterization of New Copolymer Based Cinnamyl Methacrylate Monomer: Determination of Monomer Reactivity Ratio and Statistical Sequence

“…On the other hand, García-Ruiz et al 12,13 have used the cinnamic carbohydrate for direct enzymatic immobilization of tyrosinase enzyme and horseradish peroxidase. Recently, Wang et al were interested on the synthesis of ethyl cinnamate useful for food additive and cosmetic formulation 14 . Hu et al have used methoxy cinnamic acid to improve the physiological indexes of the mushroom Agaricus bisporus and extend its shelf life 15 .…”