High wattage e-cigarette vaping induces arterial hypoxemia and tissue hypoxia in tobacco smokers suffering from coronary artery disease: A RCT

Chaumont, Martin; Zaher, Wael; Hemptinne, Quentin de; Briki, Rachid; Awada, Ahmad; Dolatabadi, Dariouch; Bar, Jean-Paul; Borne, Philippe van de; Debbas, Nadia

doi:10.1016/j.acvdsp.2019.05.079

Archives of Cardiovascular Diseases Supplements

2019

DOI: 10.1016/j.acvdsp.2019.05.079

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High wattage e-cigarette vaping induces arterial hypoxemia and tissue hypoxia in tobacco smokers suffering from coronary artery disease: A RCT

Martin Chaumont

Wael Zaher

Quentin de Hemptinne

et al.

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2024

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Expression patterns and clinical value of key m6A RNA modification regulators in smoking patients with coronary artery disease

Zhuang,

Ouyang,

Peng

et al. 2024

Epigenetics

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Even though N6-methyladenosine (m6A) RNA modifications are increasingly being implicated in human disease, their mechanisms are not fully understood in smokers with coronary artery disease (CAD). Thirty m6A-related regulators’ expression (MRRE) in CAD individuals (smokers and non-smokers) were analyzed from GEO. Support Vector Machine, random forest, and nomogram models were constructed to assess its clinical value. Consensus clustering, principal component analysis, and ssGSEA were used to construct a full picture of m6A-related regulators in smokers with CAD. Oxygen-glucose deprivation (OGD) and qRT-PCR were used to validate hypoxia’s effect on MRRE. A comparison between smokers with CAD and controls revealed lower expression levels of RBM15B, YTHDC2, and ZC3H13. Based on three key MRREs, all models showed good clinical value, and smokers with CAD were divided into two distinct molecular subgroups. The correlations were found between key MRRE and the degree of immune infiltration. Three key MRREs in HUVECs and FMC84 mouse cardiomyocytes were reduced in the OGD group. Through hypoxia, smoking might reduce the expression levels of RBM15B, YTHDC2, and ZC3H13 in smokers with CAD. Our findings provide an important theoretical basis for the treatment of smokers with CAD.

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Expression patterns and clinical value of key m6A RNA modification regulators in smoking patients with coronary artery disease

Zhuang,

Ouyang,

Peng

et al. 2024

Epigenetics

View full text Add to dashboard Cite

show abstract

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High wattage e-cigarette vaping induces arterial hypoxemia and tissue hypoxia in tobacco smokers suffering from coronary artery disease: A RCT

Cited by 1 publication

References 0 publications

Expression patterns and clinical value of key m6A RNA modification regulators in smoking patients with coronary artery disease

Expression patterns and clinical value of key m6A RNA modification regulators in smoking patients with coronary artery disease

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