High von Willebrand Factor Levels Increase the Risk of Stroke

Wieberdink, Renske G.; Schie, Marianne C. van; Koudstaal, Peter J.; Hofman, Albert; Witteman, Jacqueline C. M.; Maat, Moniek P.M. de; Leebeek, Frank W.G.; Breteler, Monique M.B.

doi:10.1161/strokeaha.110.586289

Cited by 140 publications

(110 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this large population study of British men aged 60 to 79 years, we have confirmed the findings of some previous prospective studies 9,10,13,14 that circulating levels of hemostatic markers are associated with incident stroke. We have shown that fibrin D-dimer and vWF, but not tPA antigen, are independently associated with incident stroke in older men and their measurements modestly improved prediction of stroke as assessed by improvement in the C statistics.…”

Section: Discussionsupporting

confidence: 89%

“…4 The von Willebrand factor (vWF) is synthesized primarily by vascular endothelial cells and promotes platelet adhesion and aggregation, leading to thrombus formation. 1 Increased levels of vWF in stroke patients have been reported in several case-control studies, [5][6][7][8] but prospective studies have been inconsistent, with some showing a positive relationship 9,10 and others showing no relationship [11][12][13][14] between vWF and stroke risk. Fibrin D-dimer is the primary degradation product of cross-linked fibrin and is a marker of activated coagulation and fibrinolysis.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Fibrin D-Dimer, Tissue-Type Plasminogen Activator, von Willebrand Factor, and Risk of Incident Stroke in Older Men

Wannamethee¹,

Whincup²,

Lennon³

et al. 2012

Stroke

View full text Add to dashboard Cite

Background and Purposes-Abnormalities in blood coagulation and the fibrinolytic system have been associated with increased risk of stroke, but few prospective studies have studied the associations in older adults. We have examined the associations between fibrin D-dimer, tissue-type plasminogen activator, and von Willebrand factor (vWF) and risk of stroke in older men and examined their predictive roles separately in normotensive and hypertensive men. Methods-Prospective study of 3358 men aged 60 to 79 years with no previous diagnosis of myocardial infarction or stroke and without atrial fibrillation followed-up for an average of 9 years, during which there were 187 incident stroke events. Results-Increased levels of D-dimer and vWF were associated with significantly increased risk of major stroke events after adjustment for potential confounders, including systolic blood pressure (adjusted hazard ratios and 95% confidence interval per standard deviation increase in D-dimer and vWF were 1.

show abstract

Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Fibrin D-Dimer, Tissue-Type Plasminogen Activator, von Willebrand Factor, and Risk of Incident Stroke in Older Men

Wannamethee¹,

Whincup²,

Lennon³

et al. 2012

Stroke

View full text Add to dashboard Cite

show abstract

“…10,25 Several studies have reported an association between high vWF levels and the risk of ischemic stroke. 11,43,44 We found increased vWF levels, vWF activity, and vWF HMWMs in patients with acute stroke . High plasma levels of vWF are regarded as a biomarker of endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 66%

“…7,8 Elevated vWF concentrations are associated with cardiovascular disease, 9 increased risk of ischemic heart disease, and the occurrence of acute ischemic stroke 10 ; these high levels of vWF are associated with the risk of stroke, even in the general population. 11 The biological function of vWF depends largely on the size of its multimers. 12 High-molecular-weight multimers (HMWMs) are the most efficient in hemostasis.…”

Section: Introductionmentioning

confidence: 99%

Von Willebrand Factor: Multimeric Structure and Functional Activity in Patients With Atrial Fibrillation With and Without Oral Anticoagulation

López-Castaneda

Valencia-Hernández

Arean

et al. 2017

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

von Willebrand factor (vWF) is a multimeric glycoprotein present in blood plasma. It is synthesized in megakaryocytes and endothelial cells, secreted into circulation in the form of high-molecular-weight multimers (HMWMs), and cleaved into shorter, less active multimers by ADAMTS13. It is essential for platelet adhesion and aggregation. Previous studies have investigated the relationship between vWF levels and thromboembolic events with little regard to vWF multimeric structure. Patients with atrial fibrillation (AF) exhibit higher plasma vWF and lower ADAMTS13 levels. One hundred seven patients with AF, 51 anticoagulated and 56 nonanticoagulated, were eligible for the study. Plasma samples were analyzed for vWF antigen, vWF activity, and ADAMTS13; vWF multimers were analyzed by Western blot in 1% to 1.3% sodium dodecyl sulfate agarose gel electrophoresis. Patients with AF without oral anticoagulation (OAC) had significantly higher vWF plasma levels (154.00 [75-201] UI/dL) and vWF activity (60.00% [20%-210%]) compared to patients with ] UI/dL, P ¼ <.001; 50.00% [20%-160%], P ¼ .02). Both were specially decreased in patients treated with acenocumarin. Patients without OAC also showed lower ADAMTS13 levels and presence of vWF HMWMs. Patients with AF show higher plasma levels and vWF activity. Moreover, treatment with traditional OAC (acenocumarin) significantly reduced vWF levels. Patients without OAC might have an increased risk of thrombotic events showing lower ADAMTS13 and higher vWF levels. Patients with stroke had higher plasma levels, vWF activity, and HMWMs. Our study suggests that increased vWF levels and presence of HMWMs could be related to cerebrovascular disease and may represent useful biomarkers for stroke in AF.

show abstract

“…Therefore, the level of vWF in plasma is considered to be a signalling factor of endothelial dysfunction, a condition that predisposes to atherosclerosis and thrombosis. Because of its direct role in hemostasis, and its indirect role as a signalling factor of endothelial dysfunction, vWF is a potential risk indicator for cerebrovascular disease (Wieberdink et al, 2010).…”

mentioning

confidence: 99%

The markers of platelet functions and von willebrand factor serum content from patients with type 2 diabetes mellitus and ischemic stroke

et al. 2016

View full text Add to dashboard Cite

Abstract-Introduction:The estіmated number of people with diabetes worldwide in 2015 is 415 million persons, up to 91% of adults hadtype 2 diabetes and the crude incidence of stroke among patients with diabetes of the 2 nd type can be more than 3 times that in the general population. It is known platelet activation and aggregation are critical in the pathogenesis of acute ischemic cerebrovascular diseases. Thus to examine the evidence of platelet functioning such as platelet count,aggregation in response to ADP, coagulation von Willebrand factor and serotonin content, monoamine oxidase (MAO) activity in the blood of patients with ischemic stroke and with ischemic stroke complicated with the 2 nd type diabetes are the aim of the present study. Methods: The platelet aggregation was assayed for photo-optical aggregometer, von Willebrand factor was determined by Elisa, serotonin determination included ion-exchange chromatography and fluorescence spectrophotometry. Determination of monoamine-oxidase serum activity was spectophotometry. Results: The investigation has shown an increase of serotonin and Von Willebrand factor blood content in both groups of patients with ischemic stroke andtype 2 diabetes and stroke alone compared with the values of the control group. The monoamine oxidase activity and platelet count were reduced in blood of patients with diabetes of the 2 nd type with ischemic stroke against to the values from the group of healthy donors. Platelet aggregation in response to ADP increased under the investigated pathologies. Conclusions: These obtained data suggested a significant imbalance in vascular platelet element of hemostasis under the ischemic stroke and amplification of negative changes under the stroke with the 2 nd type diabetes.

show abstract

High von Willebrand Factor Levels Increase the Risk of Stroke

Cited by 140 publications

References 35 publications

Fibrin D-Dimer, Tissue-Type Plasminogen Activator, von Willebrand Factor, and Risk of Incident Stroke in Older Men

Fibrin D-Dimer, Tissue-Type Plasminogen Activator, von Willebrand Factor, and Risk of Incident Stroke in Older Men

Von Willebrand Factor: Multimeric Structure and Functional Activity in Patients With Atrial Fibrillation With and Without Oral Anticoagulation

The markers of platelet functions and von willebrand factor serum content from patients with type 2 diabetes mellitus and ischemic stroke

Contact Info

Product

Resources

About