High‐ Versus Low‐Lipase Acid‐Resistant Enzyme Preparations in Cystic Fibrosis: A Crossover Randomized Clinical Trial
Laura Lancellotti,
Giulio Cabrini,
Luisa Zanolla
et al.
Abstract:SummaryHigh‐strength pancreatic enzyme preparations have recently come into widespread use in some countries for treatment of pancreatic insufficiency in cystic fibrosis. However, the therapeutic equivalence of these preparations to the standard acid‐resistant microsphere preparations, under the same lipase dosage, has not been demonstrated by appropriate clinical trials; they are also considered responsible for severe colonic stricture. In a randomized crossover study, 20 adolescent or adult cystic fibrosis p… Show more
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