High-value compounds from the molluscs of marine and estuarine ecosystems as prospective functional food ingredients: An overview

Chakraborty, Kajal; Joy, Minju

doi:10.1016/j.foodres.2020.109637

Cited by 44 publications

(31 citation statements)

References 371 publications

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“…The rich biodiversity and abundance of marine and estuarine mollusks, as well as their diverse range of uses as food and nutraceutical resources, have piqued the interest of food technologists and dieticians in recent years. Cephalopoda, Bivalvia, and Gastropoda were the phyla mollusca with the highest nutraceutical applications and bioactive characteristics (Chakraborty and Joy, 2020).…”

Section: Introductionmentioning

confidence: 99%

Novel Bioactive Compounds From Marine Sources as a Tool for Functional Food Development

Ghosh

Sarkar

Pati³

et al. 2022

Front. Mar. Sci.

109

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The marine environment is a relatively unexplored source of functional ingredients that can be used in food processing, storage, and fortification in a variety of ways. Marine microorganisms are a possible source of novel bioactive chemicals with potential human utility. Some of these microbes can live in the harsh marine environments, resulting in complex compounds with unique biological properties that can be used in several industrial and biotechnological applications. So far, several marine microorganisms (fungi, myxomycetes, bacteria, and microalgae) have been isolated that produce antioxidant, antibacterial, apoptotic, antitumoral, and antiviral chemicals. Furthermore, it emphasizes the enormous potential for marine microbes to produce very important bioactive chemicals. The main goal of this review is to provide a concise overview of several constituents of marine bioactives. Anticoagulant, anticancer, and hypocholesterolemic effects have been demonstrated for bioactive peptides extracted from fish protein hydrolysates, as well as algal fucans, galactans, and alginates. Furthermore, omega-3 fatty acids are abundant in fish oils and marine microorganisms, while potent antioxidants such as carotenoids and phenolic compounds can be found in crustaceans and seaweeds. This review focuses on the potential use of marine-derived chemicals as functional food ingredients for health maintenance and chronic disease prevention, based on their bioactive qualities.

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Section: Introductionmentioning

confidence: 99%

Novel Bioactive Compounds From Marine Sources as a Tool for Functional Food Development

Ghosh

Sarkar

Pati³

et al. 2022

Front. Mar. Sci.

109

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“…Many anti-tumour compounds reached late pre-clinical and clinical developments (Newman & Cragg, 2014). The high efficacy of anti-tumour bioactive compounds isolated from mollusks is due to their high selectivity, ability to overcome chemoresistance, alter biological characteristics of cancer cells, mechanisms of activation of caspases that take part in interal and external cellular apoptotic pathways, inhibition of antiogenesis, imbalance of tubulin and microtubes (Chakraborty et al, 2020). Oncological practice uses 4 preparations of mollusks: Belantamab mafodotin, Polatuzumab vedotin, Enfortumab vedotin, Brentuximab vedotin.…”

Section: Marine Organisms Producing Cytotoxic Compoundsmentioning

confidence: 99%

Anti-tumour drugs of marine origin currently at various stages of clinical trials (review)

Bocharova

Копытина

Slynko

2021

Regul. Mech. Biosyst.

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Oncological diseases for a long time have remained one of the most significant health problems of modern society, which causes great losses in its labour and vital potential. Contemporary oncology still faces unsolved issues as insufficient efficacy of treatment of progressing and metastatic cancer, chemoresistance, and side-effects of the traditional therapy which lead to disabilities among or death of a high number of patients. Development of new anti-tumour preparations with a broad range of pharmaceutical properties and low toxicity is becoming increasingly relevant every year. The objective of the study was to provide a review of the recent data about anti-tumour preparations of marine origin currently being at various phases of clinical trials in order to present the biological value of marine organisms – producers of cytotoxic compounds, and the perspectives of their use in modern biomedical technologies. Unlike the synthetic oncological preparations, natural compounds are safer, have broader range of cytotoxic activity, can inhibit the processes of tumour development and metastasis, and at the same time have effects on several etiopathogenic links of carcinogenesis. Currently, practical oncology uses 12 anti-tumour preparations of marine origin (Fludarabine, Cytarabine, Midostaurin, Nelarabine, Eribulin mesylate, Brentuximab vedotin, Trabectedin, Plitidepsin, Enfortumab vedotin, Polatuzumab vedotin, Belantamab mafodotin, Lurbinectedin), 27 substances are at different stages of clinical trials. Contemporary approaches to the treatment of oncological diseases are based on targeted methods such as immune and genetic therapies, antibody-drug conjugates, nanoparticles of biopolymers, and metals. All those methods employ bioactive compounds of marine origin. Numerous literature data from recent years indicate heightened attention to the marine pharmacology and the high potential of marine organisms for the biomedicinal and pharmaceutic industries.

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“…Molluscs provide good bioavailable sources of elemental zinc [ 200 ]. Zinc was recently shown to inhibit the replication of respiratory viruses (including influenza and COVID-19), reduce host cell infection, improve immune function, and act synergistically with standard antiviral therapies [ 201 , 202 , 203 ].…”

Section: Chemistry Bioactivity and Biomedical Applications Of Molmentioning

confidence: 99%

Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease

et al. 2020

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Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds for therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical and clinical studies using extracts and compounds derived from molluscs, as well as traditional molluscan medicines, used in the treatment of respiratory diseases. We reviewed 97 biomedical articles demonstrating the anti-inflammatory, antimicrobial, anticancer, and immunomodulatory properties of >320 molluscan extracts/compounds with direct relevance to respiratory disease, in addition to others with promising bioactivities yet to be tested in the respiratory context. Of pertinent interest are compounds demonstrating biofilm inhibition/disruption and antiviral activity, as well as synergism with approved antimicrobial and chemotherapeutic agents. At least 100 traditional medicines, incorporating over 300 different mollusc species, have been used to treat respiratory-related illness in cultures worldwide for thousands of years. These medicines provide useful clues for the discovery of bioactive components that likely underpin their continued use. There is particular incentive for investigations into anti-inflammatory compounds, given the extensive application of molluscan traditional medicines for symptoms of inflammation, and shells, which are the principal molluscan product used in these preparations. Overall, there is a need to target research toward specific respiratory disease-related hypotheses, purify bioactive compounds and elucidate their chemical structures, and develop an evidence base for the integration of quality-controlled traditional medicines.

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High-value compounds from the molluscs of marine and estuarine ecosystems as prospective functional food ingredients: An overview

Abstract: Graphical abstract

Cited by 44 publications

References 371 publications

Novel Bioactive Compounds From Marine Sources as a Tool for Functional Food Development

Novel Bioactive Compounds From Marine Sources as a Tool for Functional Food Development

Anti-tumour drugs of marine origin currently at various stages of clinical trials (review)

Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease

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