High-value biochemical products &amp; applications of freshwater eukaryotic microalgae

Russell, Callum; Rodríguez, Cristina; Yaseen, Mohammed

doi:10.1016/j.scitotenv.2021.151111

Cited by 40 publications

(27 citation statements)

References 142 publications

(142 reference statements)

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“…Carotenoids are high-value pigments produced by photosynthetic organisms with several benefits in terms of health and nutrition. These molecules are important antioxidants, and their applications range from animal feed to human food and dietary supplements, cosmetics and pharmaceuticals [ 1 , 2 , 3 ]. The global carotenoid market is expected to have a steady increase of 5% during the next decade, with carotenoid sales likely to be over 2 billion US Dollars by 2031 [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Optimal Nitrate Supplementation in Phaeodactylum tricornutum Culture Medium Increases Biomass and Fucoxanthin Production

Afonso

Bragança

Rebelo

et al. 2022

Foods

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Phaeodactylum tricornutum is a model diatom with numerous potential applications in the industry, including the production of high-value carotenoid pigments such as fucoxanthin. This compound is a potent antioxidant currently extracted mainly from brown macroalgae. Fucoxanthin exhibits several biological properties with well-known beneficial effects in the treatment and prevention of lifestyle-related diseases. P. tricornutum offers a valuable alternative to macroalgae for fucoxanthin production as it has a specific productivity that is 10-fold higher as compared with macroalgae. However, production processes still need to be optimised to become a cost-effective alternative. In this work, we investigated the optimal supplementation of nitrate in a cultivation medium that is currently used for P. tricornutum and how this nitrate concentration affects cell growth and fucoxanthin production. It has previously been shown that the addition of sodium nitrate increases productivity, but optimal conditions were not accurately determined. In this report, we observed that the continuous increase in nitrate concentration did not lead to an increase in biomass and fucoxanthin content, but there was rather a window of optimal values of nitrate that led to maximum growth and pigment production. These results are discussed considering both the scale up for industrial production and the profitability of the process, as well as the implications in the cell’s metabolism and effects in fucoxanthin production.

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Section: Introductionmentioning

confidence: 99%

Optimal Nitrate Supplementation in Phaeodactylum tricornutum Culture Medium Increases Biomass and Fucoxanthin Production

Afonso

Bragança

Rebelo

et al. 2022

Foods

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“…Thus, these data put together support our hypothesis that our findings that T1 crude extract exerts anti-proliferative effect by reducing the expression of the mutant p53 in MDA-MB-231, subsequently leading to the induction of apoptosis. Although, there are variety of H. pluvialis extracted products, research faces challenges to develop and scale up industrial production due to lack of economic support and productivity capacities ( 22 , 50 ). Future work will include the extraction and fractionation of T1 crude extract in order to identify the major bioactive compound responsible for the anti-cancer activity in T1 for therapeutics.…”

Section: Discussionmentioning

confidence: 99%

Haematococcus pluvialis Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells

et al. 2022

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Breast cancer (BC) is the most common malignant cancer in females worldwide. Drug resistance, toxicity, and the failure of current therapies to completely cure BC has challenged conventional medicine. Consequently, complementary alternative medicine has become popular due to its safety and efficacy. Haematococcus pluvialis (H. pulvialis) is a green microalga living in fresh water, and its crude extract is rich of bioactives, including carotenoids, known to inhibit cancer cell growth. In the present study, we investigated the effects of a methanol crude extract called “T1” of H. pulvialis on cell growth and migration/invasion of the BC cell line MDA-MB-231 in comparison to the fibroblast control cells. TI significantly suppressed BC cell growth, inhibited migration and invasion and induced apoptosis. Interestingly, apoptosis was mediated by a significant loss of mutant p53 protein, and increased Bax/Bcl2 ratio. Our findings support our hypothesis that T1 exerts its anti-cancer effects by inhibiting BC invasion and inducing apoptosis mediated, at least, via the p53/Bax/Bcl2 pathway. Ongoing experiments aim to identify the molecular mechanisms underpinning T1-inhibited BC cell invasion using pre-designed metastasis gene-based array method.

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“…Nowadays, microalgae are more studied for their potential use in biofuels, biogases and biopolymers [35,78], but also in aquaculture and for the depollution of wastewaters [63]. Typically, the lipids are used for biodiesel but also in cosmetics, pharmaceuticals, and nutraceuticals and in the food industry [46,58].…”

Section: Traditional and Current Usementioning

confidence: 99%

“…3 glucan, peptides, PUFAs, ß-carotene and astaxanthin, Rhodhophyceae contain phycobiliproteins (phycoerythrin, phycocyanin), carotenoids and PUFA and Bacillaryophyceae, including diatoms can contain fucoxanthin, EPA and phenolic compounds as phlorotannins[43][44][45][46][47]. The color of the diff erent types of microalgae depends on the pigment composition.…”

mentioning

confidence: 99%

“…are the most common in this industry and are employed as dietary supplements or animal food[41,80]. Chlamydomonas Reinhardtii, Porphyridium Cruentum, Chlorella, Scenedesmus and Dunaliella are genera and species seen for pharmaceutical or cosmeceutical applications because of their recombinant proteins, fatty acids and pigments[46,80,81]. In nutraceuticals, microalgae are explored in the prevention of oxidative stress…”

mentioning

confidence: 99%

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Microalgae and Diatom - Potential Pharmaceutical and Cosmetic Resources – Review

Dussably¹,

Mshvildadze²,

Pichette³

et al. 2022

J Biomed Res Environ Sci

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Microalgae are aquatic resources containing several value-added products which have been and will be widely used in various industries. They have the high potential to be explored in cosmetics and cosmeceuticals, as active ingredients in the form of isolated molecules or extracts. The aim of this review is to exhibit the potential of microalgae and especially diatoms for their cosmetic application regarding their phytochemistry and pharmacological activity. Comprehensive study of previously published literature demonstrated the presence of several antioxidant, antimicrobial or anti-inflammatory molecules in microalgae and their efficiency on human cells, particularly in anti-aging and anti-UV products. This review summarizes and discusses the information on extraction process, the chemical composition and biological activity of natural microalgae biomass. Finally, the review attempts to reveal more global view on how to valorize natural microalgal biomass, including diatoms, in cosmetics to prevent a destruction of wild resources.

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High-value biochemical products & applications of freshwater eukaryotic microalgae

Cited by 40 publications

References 142 publications

Optimal Nitrate Supplementation in Phaeodactylum tricornutum Culture Medium Increases Biomass and Fucoxanthin Production

Optimal Nitrate Supplementation in Phaeodactylum tricornutum Culture Medium Increases Biomass and Fucoxanthin Production

Haematococcus pluvialis Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells

Microalgae and Diatom - Potential Pharmaceutical and Cosmetic Resources – Review

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