High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases

Nair, Jagadeesan; Srivatanakul, Petcharin; Haas, C; Jedpiyawongse, Adisorn; Khuhaprema, Thiravud; Seitz, Helmut K.; Bartsch, Helmut

doi:10.1016/j.mrfmmm.2009.10.002

Cited by 55 publications

(57 citation statements)

References 47 publications

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“…Mediated by the above mechanisms, 4-HNE modifies tumor suppressor protein activity that is associated with chronic inflammation [42]. Apart from proteins, 4-HNE could also react in vivo with DNA and cause DNA damage by producing 1,N 6 -etheno-2 0 -deoxyadenosine, which is found to have a high urinary excretion in prehepatocellular carcinoma patients, compared to healthy volunteers [43]. These observations suggest that 4-HNE is involved in carcinogenesis in different cancers.…”

Section: Malondialdehyde the Most Mutagenic Product Of Lipid Peroxidmentioning

confidence: 99%

Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

Cai

Dupertuis

Pichard

2012

Current Opinion in Clinical Nutrition and Metabolic Care

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Recent findings CRC is one of the most overriding threats to public health. Despite a broad range of treatments, up to 50% of patients will inevitably develop incurable metastatic disease. Peroxidation of PUFAs contributes to augmentation of oxidative stress and causes in consequence inflammation, which is one of the possible carcinogenic factors of CRC. End products of PUFAs might be used as biomarkers for CRC detection and surveillance for treatment. They also have cytotoxic effect in CRC cells. Experimental results suggest that v-3 PUFAs could increase the efficacy of radiotherapy and chemotherapy of CRC. SummaryLipid peroxidation, one factor of oxidative stress, might play a paramount role not only in carcinogenesis but also in potential therapeutic strategy on CRC. End products of lipid peroxidation, such as malondialdehyde, 4-hydroxy-2-nonenal, and isoprostanes, could be used as biomarkers for cancer detection, surveillance of treatment outcome and prognostic index for CRC patients. Furthermore, malondialdehyde and 4-hydroxy-2-nonenal have cytotoxic effect not only in normal cells but also in CRC cancer cells, which implies the potential role of PUFAs in CRC treatment.

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Section: Malondialdehyde the Most Mutagenic Product Of Lipid Peroxidmentioning

confidence: 99%

Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

Cai

Dupertuis

Pichard

2012

Current Opinion in Clinical Nutrition and Metabolic Care

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“…Numerous reports have documented that LPO is an important parameter in evaluating the level of oxidative stress in organisms [56]. BaP is a very effective carcinogen with a capability to induce enormous amounts of free radicals, which in turn reacts with lipids causing LPO, the products of which include malondialdehyde that has been reported to be involved in the formation of tumors [57].…”

Section: Palanisamy and Samiappanmentioning

confidence: 99%

Antioxidant and Chemotherapeutic Potential of Curcuma Amada Rhizome Extract on Benzo(a)pyrene Induced Cervical Carcinoma in Sprague Dawley Rats

Devaraj

Samiappan²

2017

Asian J Pharm Clin Res

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Objective: To evaluate the antioxidant and chemotherapeutic potential of Curcuma amada Rhizome extract on benzo(a)pyrene (BaP) induced cervical carcinoma in Sprague Dawley rats.Methods: A total of 30 female Sprague Dawley rats were selected to establish cervical cancer model and then divided into 5 groups at random with six mice in each group. Group 1 control, Group 2 BaP (oral), Group 3 BaP for 8 weeks and post-treated with cisplatin (intravenous administration), Group 4 BaP for 8 weeks and post-treated with 250 mg of ethanol extract of C. amada (oral), Group 5 BaP for 8 weeks and post-treated with 500 mg of ethanol extract of C. amada (oral). 4 weeks after the treatment, the animals were sacrificed, serum separated, and cervical tissues were dissected. Antioxidants and the markers carcinoembryonic antigen (CEA), cancer antigens (CAs) 125, gamma glutamyltransferase (GTT) were assayed in serum and the tissue was used for analyzing tumor burden and sectioned for histopathological assays.10% tissue homogenate was estimated for antioxidants and membrane-bound enzymes.Results: BaP treated group showed significant (p<0.001) incidence of tumor burden, decreased activities of antioxidants, elevated lipid peroxidation, Na Conclusion:From the results, it can be concluded that C. amada Rhizome extract ameliorated BaP induced oxidative stress in the cervical carcinogenicity of rats.

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“…These events may induce oxidative DNA damage, which in turn increases chromosomal aberrations associated with cell transformation (Choi and Ou 2006). Oxidative stress contributes to the progression and deterioration of viral hepatitis and can be seen in various forms of HBV infection (Bolukbas et al 2005;Nair et al 2010). Malondialdehyde (MDA) is an end-product of lipid peroxidation and always employed as a serum marker of oxidative stress (Acar et al 2009).…”

mentioning

confidence: 99%

Methylation of the Glutathione-S-Transferase M3 Gene Promoter is Associated with Oxidative Stress in Acute-on-Chronic Hepatitis B Liver Failure

Zou

Wang

et al. 2012

Tohoku J. Exp. Med.

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Chronic hepatitis B (CHB) is a major cause for liver disease worldwide, ranking as the first cause for liver cirrhosis and hepatocellular carcinoma. Acute-on-chronic hepatitis B liver failure (ACHBLF) is most commonly caused by acute severe exacerbation during CHB virus infection. The pathophysiology of ACHBLF is still poorly understood. Glutathione-S-transferase (GST) M3 belongs to GSTs superfamily and it has been demonstrated to contribute to oxidative stress-mediated liver damage. The present study was aimed to determine the potential association between GSTM3 promoter methylation and oxidative stress in ACHBLF patients. Thirty ACHBLF patients, 30 CHB patients and 10 healthy controls were included in this study. Methylation of GSTM3 promoter was determined using methylation-specific PCR (MSP) method. Plasma biomarkers for oxidative stress including malondialdehyde (MDA) and GST were detected by enzyme-linked immunosorbent assay (ELISA). Model for end-stage liver disease (MELD) scoring system was used for predicting the severity and prognosis of liver failure. ACHBLF patients had significant higher GSTM3 promoter methylation rate than CHB patients (30% versus 6.7%, χ 2 = 5.455, P = 0.020). Plasma MDA and GST levels were significantly increased in ACHBLF patients compared with CHB patients. Meanwhile, MDA, MELD scores and mortality rate were significantly higher in methylated group than those in unmethylated group of ACHBLF patients. Furthermore, plasma MDA levels were positively correlated with MELD scores of ACHBLF (r = 0.588, P = 0.001). In conclusion, the methylation of GSTM3 promoter may contribute to oxidative stress-associated liver damage and correlate with the disease severity in ACHBLF.

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High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases

Cited by 55 publications

References 47 publications

Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

Antioxidant and Chemotherapeutic Potential of Curcuma Amada Rhizome Extract on Benzo(a)pyrene Induced Cervical Carcinoma in Sprague Dawley Rats

Methylation of the Glutathione-S-Transferase M3 Gene Promoter is Associated with Oxidative Stress in Acute-on-Chronic Hepatitis B Liver Failure

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