High Urinary Calcium Excretion and Genetic Susceptibility to Hypertension and Kidney Stone Disease

Mente, Andrew; Honey, R. John D'a.; Bull, Shelley B.; Logan, Alexander G.

doi:10.1681/asn.2005121309

Cited by 33 publications

(16 citation statements)

References 45 publications

(48 reference statements)

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“…Upregulation of IL-6, IL-8 and CCL2 expression and the progression of tissue injury following acute inflammation has previously been investigated (30). The urinary concentration of calcium is associated with kidney stones and is typically used as a prognostic factor for patients who have undergone surgical intervention for kidney stones (31,32).…”

Section: Discussionmentioning

confidence: 99%

Clinical importance of chemokines and inflammatory cytokines for patient care following percutaneous nephrolithotripsy

Wang

Guo

et al. 2017

Exp Ther Med

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Abstract. Chemokines are a class of proteins with low molecular weight that serve important roles in the progression of inflammation. Percutaneous nephrolithotripsy is a surgical technique in which lasers or ultrasound are utilized to break down and/or remove kidney stones. In order to ensure a full recovery following surgery, effective patient care and nursing are required. In the present study, a total of 348 patients with kidney stones were recruited and the clinical importance of chemokines and inflammatory cytokines for the nursing of patients during perioperative period was investigated. Plasma levels of inflammatory cytokines, as well as chemokines in the C, CC and CXC families, were analyzed in patients following percutaneous nephrolithotripsy. Correlations between chemokines and inflammatory cytokines and the urinary concentration of calcium oxalate were also investigated. The results indicated that plasma levels of C and CC chemokines were downregulated in patients following percutaneous nephrolithotripsy, whereas the plasma concentrations of CXC chemokines were upregulated. Plasma concentration levels of inflammatory cytokines interleukin (IL)-8, IL-1, IL-17 and tumor necrosis factor (TNF)-α were significantly downregulated in patients following percutaneous nephrolithotripsy; however, no significant differences were observed in plasma levels of IL-6 and IL-10 pre-and post-surgery. Regression analysis revealed that plasma concentration levels of chemokine C motif ligand, which is a C chemokine, chemokine ligand 2, which is a CC chemokine, and TNF-α were positively correlated with the urinary concentration of calcium oxalate during the perioperative period. The results of the present study indicate that plasma levels of chemokines and inflammatory cytokines are clinically important for nursing of patients who experienced percutaneous nephrolithotripsy. IntroductionKidney stones are a common problem affecting the urinary system that significantly affect metabolism and impede physical activity (1). Studies investigating the causes of disease have reported that several factors contribute to the formation of stones, including age, sex, ethnicity, genetic and environmental factors, dietary habits, occupation, metabolic abnormalities, urinary tract obstruction, infection and drug use (2,3). Clinical pathology has demonstrated that calcium oxalate is the primary constituent of kidney stones (4). Percutaneous nephrolithotripsy is a commonly used and effective surgical treatment for solitary kidney stones (5,6). Laparoscopy-assisted transmesocolonic percutaneous nephrolithotripsy is considered to be a safe and effective treatment option in cases of ectopic kidney stone disease (7). Clinical care is important for recovery from percutaneous nephrolithotripsy in clinical patients (8).Chemokines are a class of low molecular weight proteins that attract white blood cells to infection sites and serve an important role in immunological surveillance (9,10). Previous studies have suggested that chemokine levels may be u...

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Section: Discussionmentioning

confidence: 99%

Clinical importance of chemokines and inflammatory cytokines for patient care following percutaneous nephrolithotripsy

Wang

Guo

et al. 2017

Exp Ther Med

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“…Weight gain can affect the risk in many ways. Obese individuals have a lower urinary pH and higher uric acid excretion (which is also a risk factor for calcium oxalate stones), and they are more subject to hypertension, which in turn can cause hypercalciuria [55,56]. The availability of extended samples could clarify if nephrolithiasis and obesity simply represent two of the multiple faces of the same genetic risk, as in the case of obesity, insulin resistance, and body mass index [31].…”

Section: Animal Models Of Common Nephrolithiasismentioning

confidence: 99%

The genetic components of idiopathic nephrolithiasis

Attanasio

2010

Pediatr Nephrol

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Nephrolithiasis is a cause of significant morbidity and medical care expenses worldwide. Its prevalence has increased steadily during the last three decades among both adults and children. This trend suggests that changing environmental factors play a significant role in the risk of developing kidney stones although, conversely, there are many indications that genes play an important role in this condition as well. A limited number of monogenic forms have been identified, but the majority of nephrolithiasis cases are the result of complex, multi-factorial interactions between genetic inheritance and environmental exposure. Scientific evidence indicates that inheritance accounts for about half of the risk of common forms, making these forms suitable for investigation by genetic analysis. Here, we review the numerous studies that have been conducted to establish the role of genes in determining the risk of nephrolithiasis, the differential contribution of genes to this risk, and the confounding influence that environmental variables have on genetic studies.

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“…These factors are also related to an increased risk of coronary heart disease (CHD) and/or stroke [13][14][15][16][17][18]. Thus, pathways that contribute to renal calculi formation, e.g., an increased urinary calcium excretion like in hypertension or obesity [19], may also play a role in the development of subclinical cardiovascular diseases (CVD) and the occurrence of myocardial infarction and stroke. Indeed, an increased risk of myocardial infarction has been observed in persons with renal calculi compared to matched controls [20].…”

Section: Introductionmentioning

confidence: 99%

Relationship between renal calculi and the risk of myocardial infarction and stroke: results from the EPIC-Potsdam study

Wirth¹,

Weikert²,

Giuseppe³

et al. 2014

Clin Nephrol Urol Sci

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Background: Renal calculi are related to obesity and metabolic syndrome and may indicate an increased risk of cardiovascular disease, but data from prospective cohort studies are sparse. Therefore, the authors investigated the association between renal calculi and the risk of cardiovascular disease endpoints in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Methods: The study population comprised 24,490 individuals aged mainly 35-65 years, who were free of cardiovascular diseases at recruitment (1994)(1995)(1996)(1997)(1998). Information about the presence of renal calculi at baseline was ascertained via questionnaires. For all incident cases of myocardial infarction and stroke, confirmation was obtained from the attending physician. Hazard rate ratios (HR) were estimated using Cox proportional hazards regression. Results: During a mean follow-up of 8.1±1.6 years, 494 cases of cardiovascular disease were identified. Among persons with renal calculi (n=2,645), incidence rates were higher and selected cardiovascular risk factors were more common than among those without renal calculi. In multivariable adjusted models, no association between renal calculi and the risk of cardiovascular diseases (HR=1.05, 95% confidence interval (CI): 0.82-1.34) was observed. Endpoint specific analyses revealed similar results. In subanalyses restricted to fatal endpoints, a more than twofold increased risk of fatal myocardial infarction was observed in persons with renal calculi, but this association did not reach statistical significance (HR=2.33, 95% CI: 0.88-6.13). The HR of fatal stroke was 1.24 (95% CI: 0.46-3.33) in persons with renal calculi compared to those without. Conclusions: The authors observed a higher prevalence of cardiovascular risk factors in individuals with renal calculi but no independent relationship between the presence of renal calculi and the risk of myocardial infarction and stroke.

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High Urinary Calcium Excretion and Genetic Susceptibility to Hypertension and Kidney Stone Disease

Cited by 33 publications

References 45 publications

Clinical importance of chemokines and inflammatory cytokines for patient care following percutaneous nephrolithotripsy

Clinical importance of chemokines and inflammatory cytokines for patient care following percutaneous nephrolithotripsy

The genetic components of idiopathic nephrolithiasis

Relationship between renal calculi and the risk of myocardial infarction and stroke: results from the EPIC-Potsdam study

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