High uptake of colonoscopy in first-degree relatives of patients with colorectal cancer in a healthcare region: a population-based, prospective study

Armelao, Franco; Orlandi, P. G.; Tasini, E.; Franceschini, Gaia; Franch, R.; Paternolli, Corrado; Pretis, G. De

doi:10.1055/s-0029-1215324

Cited by 29 publications

(28 citation statements)

References 27 publications

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“…As previously reported, 11 starting in December 2005, FHs from patients with newly diagnosed CRC were prospectively collected. All new cases of CRC were ascertained by a pathological diagnosis.…”

Section: Screening Designmentioning

confidence: 99%

“…They were asked to provide the FH on a special form and to mail it back to the Screening dei Familiari a Rischio di Cancro Colorettale coordinating center. 11 Inclusion criteria were (1) FDRs either between the ages of 45 and 75 years or 10 years younger than the youngest patient with CRC in the family and (2) FDRs residing in the APSS catchment area. Exclusion criteria were (1) having undergone a colonoscopy or barium enema in the 5 years before the study and (2) a history of hereditary CRC syndromes, inflammatory bowel diseases, and/or severe comorbidities.…”

Section: Screening Designmentioning

confidence: 99%

“…In our previous study, we evaluated factors that influence the use of screening colonoscopies in our population. 11 In this study, we describe colorectal findings among FDRs undergoing a screening colonoscopy and compare them with findings of average-risk subjects undergoing a colonoscopy as a primary screening tool (first objective). Our secondary objective was to identify features that might allow the use of risk stratification for colorectal neoplasia among this increased-risk group.…”

mentioning

confidence: 99%

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Colonoscopic findings in first-degree relatives of patients with colorectal cancer: a population-based screening program

Armelao

Paternolli

Franceschini

et al. 2011

Gastrointestinal Endoscopy

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Section: Screening Designmentioning

confidence: 99%

Section: Screening Designmentioning

confidence: 99%

mentioning

confidence: 99%

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Colonoscopic findings in first-degree relatives of patients with colorectal cancer: a population-based screening program

Armelao

Paternolli

Franceschini

et al. 2011

Gastrointestinal Endoscopy

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“…Therefore, more detailed information should be provided to subjects with a family history of CRC regarding the safety of colonoscopy and the possibility of performing the procedure under sedation. In this regard, general practitioners play a decisive role, especially in lesseducated people who are less likely to obtain information in other ways [22,58,70,71] . High-quality colonoscopy is crucial to achieve good CRC screening, therefore several technical factors have to be taken into account [37] .…”

Section: Screening Colonoscopymentioning

confidence: 99%

Familial colorectal cancer screening: When and what to do?

Blanco¹,

Paoluzi²,

Sileri³

et al. 2015

WJG

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Colorectal cancer (CRC) is the third leading cause of death worldwide and represents a clinical challenge. Family members of patients affected by CRC have an increased risk of CRC development. In these individuals, screening is strongly recommended and should be started earlier than in the population with average risk, in order to detect neoplastic precursors, such as adenoma, advanced adenoma, and nonpolypoid adenomatous lesions of the colon. Fecal occult blood test (FOBT) is a non invasive, widespread screening method that can reduce CRC-related mortality. Sigmoidoscopy, alone or in addition to FOBT, represents another screening strategy that reduces CRC mortality. Colonoscopy is the best choice for screening highrisk populations, as it allows simultaneous detection and removal of preneoplastic lesions. The choice of test depends on local health policy and varies among countries. Core tip: One-fifth of people who develop colorectal cancer (CRC) have a first-degree relative (FDR) affected by this malignancy. Screening is an efficient method to reduce mortality for CRC and should be started in FDRs earlier than in the population at average risk. There is a large disparity in guidelines for screening in familial CRC, therefore, here we address the principal indication and methods for screening in this population at increased risk. Recent or emerging methods to improve the participation rate in screening programs are described. Ongoing trials on CRC screening are also reported.

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“…There is some evidence to suggest that telephone or face‐to‐face counselling is effective in improving screening rates among first degree relatives of CRC patients 12 , 13 , 14 . However, such approaches may not be feasible to implement due to the costs involved.…”

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confidence: 99%

Can a print‐based intervention increase screening for first degree relatives of people with colorectal cancer? A randomised controlled trial

Carey

Sanson‐Fisher

Macrae

et al. 2016

Australian and New Zealand Journal of Public Health

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Objective: To test the effectiveness of a targeted print‐based intervention to improve screening adherence in first degree relatives of people with colorectal cancer (CRC). Methods: People with CRC and their adult first degree relatives were identified through a population‐based cancer registry and randomly allocated as a family unit to the intervention or control condition. The control group received general information about CRC screening. The intervention group received printed advice regarding screening that was targeted to their risk level. Screening adherence was assessed at baseline and at 12 months via self report. Results: 752 (25%) index cases and 574 (34%) eligible first degree relatives consented to take part in the trial and completed baseline interviews. At 12 months, 58% of first degree relatives in the control group and 61% in the intervention group were adherent to screening guidelines (mixed effects logistic regression group by time interaction effect =2.7; 95%CI=1.2–5.9; P=0.013). Subgroup analysis indicated that the intervention was only effective for those with the lowest risk. Conclusions: Provision of personalised risk information may have a modest effect on adherence to CRC screening recommendations among first degree relatives of people diagnosed with CRC. Implications : Improved strategies for identifying and engaging first degree relatives are needed to maximise the population impact of the intervention.

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High uptake of colonoscopy in first-degree relatives of patients with colorectal cancer in a healthcare region: a population-based, prospective study

Abstract: Interventions that target FDRs of patients with CRC, especially those younger than 60 years, with a complex family history of CRC and who live in a rural area, may improve uptake of CRC screening via colonoscopy.

Cited by 29 publications

References 27 publications

Colonoscopic findings in first-degree relatives of patients with colorectal cancer: a population-based screening program

Colonoscopic findings in first-degree relatives of patients with colorectal cancer: a population-based screening program

Familial colorectal cancer screening: When and what to do?

Can a print‐based intervention increase screening for first degree relatives of people with colorectal cancer? A randomised controlled trial

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