High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma

Xia, Weiya; Lau, Yiu Keung; Hu, Mickey C.T.; Li, Lei; Johnston, Dennis A.; Shi, Sheng; El‐Naggar, Adel K.; Hung, Mien‐Chie

doi:10.1038/sj.onc.1203535

Cited by 134 publications

(134 citation statements)

References 10 publications

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“…Recently, Xia et al [33] and Yasumatsu et al [34] demonstrated that maspin is expressed in a subset of oral SCCs with favorable prognosis; in accordance with the findings of Yasumatsu et al [34], in the present study we also observed that maspin is preferentially expressed in well-differentiated SCCs. Moreover, maspin was consistently expressed in almost all squamous pearls.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, maspin was consistently expressed in almost all squamous pearls. As previously reported [33,34], maspin expression was not statistically correlated with other pathological features of SCCs, including cell proliferation, growth pattern, and degree of desmoplasia in the stroma. This is the first study to evaluate maspin expression in BCC of the skin.…”

Section: Discussionsupporting

confidence: 54%

“…It is also considered as a suppressor of invasion, motility, proliferation, and metastatic potential of neoplastic cells [9,5,6,11,12,14,15,16,17,18,20,21,22,23,24,25,27,28,31,35,36,37]. Moreover, there are controversial data on the role of maspin as a downstream factor of p53 pathway [9,14,18,33,37,38].…”

Section: Discussionmentioning

confidence: 99%

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Maspin expression in normal skin and usual cutaneous carcinomas

et al. 2002

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Maspin is a serine protease inhibitor whose gene is located on 3q27. Several lines of evidence point towards its putative role as tumor suppressor gene and angiogenesis inhibitor; however, there are compelling data showing that maspin is also expressed in the nuclear compartment and might be associated with the differentiation of specific cell lineages. No systematic study of maspin expression in normal skin and usual skin carcinomas have been published so far. We semiquantitatively analyzed the distribution and immunoreactivity pattern of maspin in 14 squamous cell carcinomas (SCCs) and 16 basal cell carcinomas (BCCs) and in the adjacent normal epidermis of all cases. We also examined the correlation of maspin expression with histological type, grade, vascular invasion, perineural infiltration, and mitotic counting. Cytoplasmic expression of maspin was observed in suprabasal, prickle, and granular cell layers of normal epidermis; cells of the germinative hair matrix, Henle's and Huxley's layers, and cuticle of hair follicles; mature sebaceous cells and sweat gland's secretory cells. Nuclear expression was detected in some basal/myoepithelial cells of the sweat glands and scattered mature sebaceous cells. All SCCs but one grade IV SCC showed maspin expression, and it was correlated with the differentiation of these neoplasms. BCCs presented variable maspin expression, while metatypical carcinomas showed moderate to intense maspin expression, nodular BCCs variable contents of maspin and displayed a peculiar distribution, confined to the center of the neoplastic nodules. Two BCCs and one SCC showed maspin nuclear expression. No correlation with other clinical pathological features was observed. Our findings do not support the role of maspin as a tumor suppressor gene and suggest that this serpin is probably associated with specific lines of differentiation.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 54%

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Maspin expression in normal skin and usual cutaneous carcinomas

et al. 2002

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“…The maspin gene was originally identified in normal human breast epithelium as encoding a 42 kDa cytoplasmic protein, and is known to have tumour suppressive activity attributable to the inhibition of breast cancer cell motility, invasion, and metastasis Zou et al, 1994;Seftor et al, 1998). Similarly, the tumour suppressive activity of maspin has been demonstrated for prostate cancer (Umekita et al, 1997), oral carcinoma (Xia et al, 2000), and colon cancer . The prognostic significance of maspin has also been demonstrated in breast cancer (Seftor et al, 1998) and squamous cell carcinoma of the oral cavity (Xia et al, 2000).…”

Section: Expression Of Maspin In Gastric Cancermentioning

confidence: 85%

Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis

et al. 2005

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To seek for a candidate gene that would regulate tumour progression and metastasis in gastric cancer, we investigated gene expression profiles by using DNA microarray. Tumour tissue and adjacent normal tissue were obtained from 21 patients with gastric cancer and then examined for their gene expression profiles by the Gene Chip s Human U95Av2 array, which includes 12 000 human genes and EST sequences. A total of 25 genes were upregulated and two genes were downregulated by at least four-fold in the tumour tissue. In a further analysis according to lymph node metastasis, the expressed levels of maspin, as well as carcinoembryonic antigen and nonspecific crossreacting antigen were significantly higher in tumours with lymph node metastasis than in those without it. Maspin expression in 85 gastric cancer patients was further investigated by using immunohistochemistry. Maspin expression was not observed in normal gastric epithelia without intestinal metaplasia. In contrast, maspin was expressed in 74 of 85 tumour tissues. There was a significant correlation between the incidence of maspin-positive tumour staining and lymph node metastasis. These results suggest that maspin has a potential role for tumour metastasis in gastric cancer.

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“…HDAC inhibitor should undergo further examination not only as an anti-angiogenesis agent, but also regarding its role in maspin re-expression to explore its potential as a possible biomarker for relapse risk in cancer therapy, as alterations in maspin expression are known to play an important role in oral tumorigenesis. In oral squamous cell carcinoma, high levels of maspin expression are associated with the absence of lymph node metastasis and with 13 better rates of overall survival [33].…”

Section: Discussionmentioning

confidence: 99%

Effects of demethylating agent 5-aza-2′-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cancer cell lines

Murakami¹,

Asaumi²,

Maki³

et al. 2004

Oral Oncology

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Summary Maspin, which belongs to the serine protease inhibitor (serpin) superfamily, has been proposed as a potent tumor suppressor that inhibits cell motility, invasion, angiogenesis, and metastasis. In the present study, we examined the effects of 5-Aza-2'-deoxycytidine (5-Aza-dC), a demethylating agent, and FR901228, a histone deacetylase (HDAC) inhibitor, on maspin expression in oral cancer cell lines. The expression levels of maspin mRNA were divided into two groups, which was the maspin low-expressed and high-expressed cell lines in the 12 oral cancer cell lines. The maspin promoter contained only a few methylated CpG sites in the maspin low-expressed cell lines. Moreover, the methylation status was not altered after 5Aza-dC treatment. However, the transcription of the maspin gene was clearly increased following 5Aza-dC treatment in a number of oral cancer cell lines. These results imply that an action of 5Aza-dC is separate from induction of promoter demethylation. Treatment with FR901228 resulted in a time-dependent stimulation of the re-expression of maspin mRNA as early as 4 hours after treatment in the maspin downregulated cells. The re-expression of the maspin gene may contribute to the recuperation of biological functions linked to FR901228 such as an inhibitory effect on tumor angiogenesis and cell invasion. These results indicate that maspin and its target genes may be excellent leads for future studies on the potential benefits of FR901228, a histone deacetylase inhibitor, in cancer therapy.

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High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma

Cited by 134 publications

References 10 publications

Maspin expression in normal skin and usual cutaneous carcinomas

Maspin expression in normal skin and usual cutaneous carcinomas

Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis

Effects of demethylating agent 5-aza-2′-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cancer cell lines

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