High triglyceride-glucose index is associated with adverse cardiovascular outcomes in patients with acute myocardial infarction

Abstract

Background Triglyceride glucose (TyG) index is considered a new marker for metabolic disorders. Although recent studies have found an association between TyG index level and vascular disease development, the prognostic value of TyG index in patients with acute myocardial infarction (AMI) remains unclear. Methods A total of 3181 patients with AMI, who underwent coronary angiography, were identified from the Cardiovascular Center of Beijing Friendship Hospital Database Bank and included in the analysis. Patients were stratified into 2 groups according to their baseline TyG index levels: the TyG index <8.88 group and the TyG index ≥8.88 group. Clinical characteristics,biochemical parameters, and the incidence of major adverse cardiovascular events (MACEs) during a median of 33.3-month follow-up were recorded. The TyG index was calculated using the following formula: ln [fasting triglycerides (mg/dL) ×fasting plasma glucose (mg/dL)/2]. Results Compared with the TyG index<8.88 group, the TyG index≥8.88 group had significantly higher incidences of non-fatal MI, revascularization, cardiac rehospitalization and composite MACEs. Multivariable Cox regression models revealed that the TyG index was positively associated with all-cause death [HR (95% CI): 1.51 (1.10,2.06), P=0.010], cardiac death [HR (95%CI): 1.68 (1.19,2.38), P=0.004], revascularization [HR (95%CI): 1.50 (1.16,1.94), P=0.002], cardiac rehospitalization [HR (95%CI): 1.25 (1.05,1.49), P=0.012], and composite MACEs [HR (95%CI): 1.19 (1.01,1.41), P=0.046] in patients with AMI. The independent predictive effect of TyG index on all-cause death and cardiac death was mainly reflected in the subgroups of male gender, body mass index ≥25kg/m 2 , smoker, diabetes mellitus, estimated glomerular filtration rate (eGFR) ≥60ml/min/1.73m 2 , high-density lipoprotein cholesterol ≥1.01mmol/L and left ventricular ejection fraction (LVEF) ≥0.50. The results also revealed that diabetes mellitus, previous AMI, eGFR, LVEF, and multi-vessel/left main coronary artery lesions were independent predictors of MACEs in patients with AMI (all P<0.05). Conclusions High TyG index levels appeared to be associated with an increased risk of MACEs in patients with AMI. The TyG index might be a valid predictor of cardiovascular outcomes of patients with AMI.

Impacto del índice triglicéridos-glucemia en la mortalidad intrahospitalaria por infarto agudo del miocardio. Resultados del registro multicéntrico RECUIMA

“…The TyG index construct was calculated based on fasting triglycerides and blood glucose values, using the formula derived from previous studies: [6][7][8][9] Ln[triglycerides (mmol/L) • 0.01129 • blood glucose…”

“…The triglyceride-glucose (TyG) index has recently been introduced as a method for insulin resistance, coronary atherosclerosis and adverse events presumptive diagnosis in acute coronary syndrome. [6][7][8][9] However, its relationship with in-hospital mortality in patients who suffer a STEMI has been poorly studied in international reports. For this reason, this research is carried out, with the purpose to evaluate the capability of TyG index to predict in-hospital mortality in patients with STEMI.…”

Triglyceride glucose index is independently associated with aortic intima-media thickness in patients without known atherosclerotic cardiovascular disease or diabetes

“…It is beneficial for estimating the risk of adverse prognosis of symptomatic and asymptomatic coronary artery disease and acute myocardial infarction. 11,12 In addition, there is evidence that the TyG index is also correlated with asymptomatic carotid artery atherosclerosis. 13 We aimed to examine the relationship between the TyG index and the thoracic aorta’s intima-media thickness (IMT) in patients who underwent transoesophageal echocardiography for suspected structural heart disease such as atrioventricular septal defect, patent foramen ovale, and valvular heart diseases.…”

Triglyceride Glucose Index Is Independently Associated With Aorta Intima-Media Thickness In Patients Without Clinical Manifestations of Cardiovascular Disease

“…As a good marker of insulin resistance, the TyG index is associated with an increased risk of diabetes mellitus [8], stroke [9], coronary artery disease [10,11] in healthy individuals. It is bene cial for estimating the risk of adverse prognosis of symptomatic and asymptomatic coronary artery disease and acute myocardial infarction [12][13][14]. In addition, there is evidence that the TyG index is also correlated with asymptomatic carotid artery atherosclerosis [15].…”