High triglyceride glucose index is more closely associated with hypertension than lipid or glycemic parameters in elderly individuals: a cross-sectional survey from the Reaction Study.

Abstract

Background: Both lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether triglyceride-glucose (TyG) index is associated with HTN. Therefore, the aim of this study is to investigate the association of TyG index and HTN and compare the discriminative power of TyG index, lipid, glycemic parameters for the risk of HTN in the elderly individuals.Methods: The present study was nested in a longitudinal (REACTION) study from May 2011 to December 2011, which was designed to demonstrate the association of abnormal glucose metabolism with the risk of cancer in the Chinese population. 43591 participants were recruited in this cross-sectional study. TyG index were divided into 5 groups: <20% group, the 20-39% group, the 40-59% group, the 60-79% group and the ≥80% group according quartile division of the subjects. Three multivariate logistic regression models were used to evaluate the association between TyG v.s lipid parameters, glycemic parameters and HTN.Results: Multivariate logistic regression analysis shows that compared with lipid and glycemic parameters, TyG index remains significantly associated with HTN in either total subjects or subjects separated into men and women (odds ratio (OR) 1.33, 95% confidence interval (CI) 1.18-1.51, p <0.0001 in total subjects; OR 1.39, 95% CI 1.11-1.74, p=0.0042 in men; OR 1.28, 95% CI 1.11-1.49, p=0.0010 in women). In stratified analysis, elevated TyG index is significantly associated with HTN in the subgroup of oldest age (≥65) (OR 1.67, 95% CI 1.30-2.14, p <0.0001), obesity (Body mass index (BMI) ≥28 kg/m2) (OR 1.85, 95% CI 1.29-2.66, p 0.0009) or lower estimated glomerular filtration rate (eGFR) (<90 mL/ (min·1.73 m2)) (OR 1.72, 95% CI 1.33-2.21, p <0.0001).Conclusion: TyG index is significantly associated with HTN and shows the superior discriminative ability for HTN compared with lipid and glycemic parameters in the Chinese elderly population.

The association of triglyceride and glucose index, and triglyceride to high‐density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross‐sectional population study

“…14 However, few of these studies have large samples to evaluate the relationship between non-insulin resistance indicators and hypertension, as well as prehypertension in the same population. 10,[13][14][15][16][17][18][19][20][21][22][23] Therefore, we conducted a large cross-sectional study to explore the association of TyG index, TG/HDL-c ratio with prehypertension and hypertension in the same normoglycemic subjects from Tianjin, China.…”

Association of Lipid Accumulation Product With Chronic Kidney Disease in Chinese Community Adults: A Report From the REACTION Study

“…CKD was de ned as eGFR <60mL/min/1.73m² and/or presence of albuminuria (ACR ≥30mg/g) [3]. Participants were divided into appropriate (LDL-C< 3.4 mmol/L), borderline high (3.4mmol/L≤LDL-C< 4.1 mmol/L), and high (LDL-C≥ 4.1 mmol/L) groups based on the 2016 Chinese guideline for the management of dyslipidemia in adults [18]. According to the criteria in previously published articles [14,15], type 2 diabetes mellitus (T2DM), prediabetes, and normal glucose tolerance (NGT) were diagnosed.…”

“…A brachial PP ≥63 mmHg was considered abnormal (high pulse pressure) [19,20]. CVD events included myocardial infarction (MI), coronary heart disease (CHD), stroke, and peripheral arterial disease (PAD), and the detailed de nitions have been described in previously published articles [14,15,18,21].…”