High titers of Epstein-Barr virus antibodies in adult patients with lymphocytic interstitial pneumonitis associated with AIDS

Kramer, Martin; Saldana, Mario J.; Ramos, Marcelo de Carvalho; Pitchenik, Arthur E.

doi:10.1016/s0954-6111(06)80148-4

Cited by 27 publications

(12 citation statements)

References 14 publications

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“…The titres of EB virus antibodies (VCA, EA and EBNA) were significantly higher in adult patients with LIP associated with AIDS compared to non-LIP patients with AIDS. These LIP patients demonstrated a pattern of recent recrudescent EB virus infection, while most non-LIP patients showed a pattern of past EB virus infection [22]. HSV was also known to cause interstitial pneumonitis in immunocompromised patients [23].…”

Section: Discussionmentioning

confidence: 99%

Elevation of antibodies to cytomegalovirus and other herpes viruses in pulmonary fibrosis

Yonemaru¹,

Kasuga²,

Kusumoto³

et al. 1997

Eur Respir J

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The aim of this study was to determine whether latent viral infection is associated with idiopathic pulmonary fibrosis (IPF), an interstitial lung disease whose aetiology remains to be elucidated.Cytomegalovirus ( Increases in cytomegalovirus immunoglobulin G and complement fixation titres with negative cytomegalovirus immunoglobulin M suggest that latent cytomegalovirus infection may be more prominent in idiopathic pulmonary fibrosis or collagen vascular disease-related interstitial pneumonitis. Together with the elevation of EpsteinBarr virus viral capsid antigen and herpes simplex virus immunoglobulin G in idiopathic pulmonary fibrosis and/or collagen vascular disease-related interstitial pneumonitis, it is rational to assume that these viruses may be implicated in the development of pulmonary fibrosis. Further study is necessary to investigate the relationship between latent viral infection and pulmonary fibrosis.

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Section: Discussionmentioning

confidence: 99%

Elevation of antibodies to cytomegalovirus and other herpes viruses in pulmonary fibrosis

Yonemaru¹,

Kasuga²,

Kusumoto³

et al. 1997

Eur Respir J

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show abstract

“…The titers of EBV antibodies (viral capsid antigen, early antigen and nuclear antigen) were significantly higher in adult patients with LIP associated with AIDS compared with non-LIP patients with AIDS. These LIP patients demonstrated a pattern of recent recrudescent EBV infection, while most non-LIP patients showed a pattern of past EBV infection [15].…”

Section: Epstein--barr Virus and Lymphocytic Interstitial Pneumonitismentioning

confidence: 94%

Epstein-Barr-virus-induced interstitial lung disease

Marzouk

Corate

Saleh

et al. 2005

Current Opinion in Pulmonary Medicine

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Using monoclonal antibodies against viral antigen Epstein-Barr virus was shown to replicate within type II alveolar cells of adult idiopathic pulmonary fibrosis patients. Latent membrane protein 1positivity indicates poor prognosis; Epstein-Barr virus positivity did not increase the incidence of lung cancer in these patients. Epstein-Barr virus was also associated with lymphocytic interstitial pneumonia, AIDS and Langerhans cell histiocytosis but not with sarcoidosis.

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“…Therefore, whilst malignant transformation can rarely occur, 72,73 LIP is currently viewed as a pattern of diffuse reactive pulmonary lymphoid hyperplasia. In reality, idiopathic LIP is exceptionally rare, as most cases are associated with either Epstein–Barr virus, immunosuppression or a connective tissue disorder 74–80 . Nevertheless, it remains within the consensus classification system for idiopathic disease 20 .…”

Section: Lymphocytic Interstitial Pneumoniamentioning

confidence: 99%

“…In reality, idiopathic LIP is exceptionally rare, as most cases are associated with either Epstein-Barr virus, immunosuppression or a connective tissue disorder. [74][75][76][77][78][79][80] Nevertheless, it remains within the consensus classification system for idiopathic disease. 20 Patients with LIP are usually female, with an average age at presentation of about 50 years.…”

Section: Lymphocytic Interstitial Pneumoniamentioning

confidence: 99%

Classification of idiopathic interstitial pneumonias: making sense of the alphabet soup

Nicholson

2002

Histopathology

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Since Liebow and Carrington's original classification of idiopathic interstitial pneumonias, there have been controversies over which histological patterns should be included and how they relate to clinicopathological diseases such as cryptogenic fibrosing alveolitis/idiopathic pulmonary fibrosis (CFA/IPF). Because of these differences and the wealth of overlapping terminology, a consensus classification system has been proposed, devised by a group of clinicians, radiologists and pathologists. Seven histological patterns are recognized: usual interstitial pneumonia (UIP), non-specific interstitial pneumonia (NSIP), diffuse alveolar damage (DAD), organizing pneumonia (OP), desquamative interstitial pneumonia (DIP), respiratory bronchiolitis (RB) and lymphocytic interstitial pneumonia (LIP), each with a clinicopathological counterpart, the most well defined being UIP and CFA/IPF. The system is applicable both in terms of the pathologist identifying histological patterns in isolation and in terms of the pathologist's role in contributing to the final clinicopathological diagnosis. It will probably provide greater consistency in diagnosis, early studies suggesting that the system is reproducible, and also identify purer cohorts for studies investigating causation. It also highlights the fact that the 'gold standard for diagnosis' is no longer a surgical lung biopsy in isolation but more the clinicopathological conference, when clinical, imaging and histological data are jointly discussed to produce the final clinicopathological diagnosis.

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High titers of Epstein-Barr virus antibodies in adult patients with lymphocytic interstitial pneumonitis associated with AIDS

Cited by 27 publications

References 14 publications

Elevation of antibodies to cytomegalovirus and other herpes viruses in pulmonary fibrosis

Elevation of antibodies to cytomegalovirus and other herpes viruses in pulmonary fibrosis

Epstein-Barr-virus-induced interstitial lung disease

Classification of idiopathic interstitial pneumonias: making sense of the alphabet soup

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