High-titer antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis

Targan, Stephan R.; Landers, Carol J.; Vidrich, Alda; Czaja, Albert J.

doi:10.1016/0016-5085(95)90215-5

Cited by 177 publications

(85 citation statements)

References 33 publications

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“…Moreover, PSC and AIH share similar genetic predispositions to autoimmunity. Both diseases have been associated with haplotypes HLA-B8 and HLA-DR3 (28). In addition, perinuclear antineutrophil cytoplasmatic antibody (pANCA), smooth muscle antibodies, and antinuclear antibodies have been shown in both PSC and AIH patients (29,30).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for and Clinical Course of Non‐Anastomotic Biliary Strictures After Liver Transplantation

Guichelaar

Benson

Malinchoc

et al. 2003

American Journal of Transplantation

267

246

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Non-anastomotic biliary stricture (NAS) formation is a major complication of liver transplantation. We prospectively determined the time to development of responsiveness to treatment, and clinical outcomes following NAS formation. In addition, an extensive analysis of the association of recipient, donor, and clinical variables with NAS formation was performed. A total of 749 consecutive patients was studied in a prospective, protocol-based fashion. Seventy-two patients (9.6%) developed NAS at a mean of 23.6 ± 34.2 weeks post-transplantation. Non-anastomotic biliary stricture formation resolved in only 6% of affected patients. Although patient survival was not affected, retransplantation and graft loss rates were significantly greater in recipients who developed NAS. In contrast to previous reports, a pretransplant diagnosis of HCV was associated with a low frequency of NAS formation. The incidence of NAS was independently associated with pretransplant diagnoses of PSC and autoimmune hepatitis. Hepatic artery thrombosis, and prolonged warm and cold ischemia times were also independent risk factors for NAS formation. We conclude that NAS developed in~10% of primary liver transplant recipients. A pretransplant diagnosis of autoimmune hepatitis has been identified as a novel independent risk factor for NAS formation. Development of NAS significantly attenuates graft but not patient survival.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for and Clinical Course of Non‐Anastomotic Biliary Strictures After Liver Transplantation

Guichelaar

Benson

Malinchoc

et al. 2003

American Journal of Transplantation

267

246

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show abstract

“…Atypical pANCA, the autoantibody most closely associated with PSC, is present in up to 85% of cases 25 and may also be detected in at least 5% of patients with PBC 31 as well as most patients with AIH. 32 In contrast to PBC therefore, clinical, biochemical, and serologic criteria poorly define PSC. Instead, the diagnosis rests on distinctive cholangiographic appearances showing large intrahepatic and extrahepatic bile duct involvement.…”

Section: The Diagnosis Of Pscmentioning

confidence: 99%

Autoimmune Overlap Syndromes

2001

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“…Although neither patient reported by Nakamotoet al and Goritsas et al had positive antiphospholopid antibodies, different autoantibodies might result in similar diseases of the liver. It was also noted that ANCAs were found frequently not only in patients with PSCand ulcerative colitis but also in those with type-1 autoimmune hepatitis (8). Most of the patients with type-1 autoimmune hepatitis expressed only IgGl subclass PANCA, contrasting with a small number of the patients with PSC with IgGl subclass PANCA.…”

Section: Toimmune Hepatitismentioning

confidence: 97%

Antineutrophil Cytoplasmic Antibody-related Vasculitis and Liver Diseases

Hashimoto

2000

Intern. Med.

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High-titer antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis

Cited by 177 publications

References 33 publications

Risk Factors for and Clinical Course of Non‐Anastomotic Biliary Strictures After Liver Transplantation

Risk Factors for and Clinical Course of Non‐Anastomotic Biliary Strictures After Liver Transplantation

Autoimmune Overlap Syndromes

Antineutrophil Cytoplasmic Antibody-related Vasculitis and Liver Diseases

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