“…7 In choosing a polymer scaffold, we decided to explore the use of dextrans due to their well-established clinical safety record, hydrophilicity, low expense, ready availability in numerous molecular weights, and our previous experience working with dextran imaging agents. 7,12,13 Dextrans with amine leashes and radionuclide agents have been extensively studied as radionuclide imaging agents for sentinel lymph node detection. 3,14,15 In order to chelate the 68 Ga, we decided to utilize DTPA chelation groups based on prior clinical work with DTPA albumins and dextrans and the known stability of DTPA chelates 16,17 which exhibit adequate in vivo stability for gallium during the moderately short biological half-life of the dextran conjugates.…”