High Tidal Volume and Positive Fluid Balance Are Associated With Worse Outcome in Acute Lung Injury

Characteristics of patients readmitted to intensive care unit: a nested case-control study

“…26,27 Another finding in this study was the effect of fluid balance in the pre-discharge period. Previous studies have illustrated the association of fluid overloading and deleterious outcomes in critically ill patients, including those with sepsis, 28 acute kidney injury, 29 acute lung injury, 28,30 and following operations. 31 A single-centre study in Japan 32 found that weight gain at the time of initial ICU discharge had a negative linear relationship with the time to ICU readmission, as well as PaO 2 -to-FiO 2 ratio.…”

Early Effect of Tidal Volume on Lung Injury Biomarkers in Surgical Patients With Healthy Lungs

“…Understanding the early inflammatory changes triggered by different V T in healthy lungs, and the relationship of these changes with ventilatory parameters, may help identify injurious pulmonary insults and susceptible individuals. This knowledge may complement recently developed risk scores for predicting ARDS [15][16][17][18][19] or postoperative pulmonary complications 13,20 in their goal of early detection and prevention of lung inflammation.…”

Prescribing Patterns of Drugs in Acute Respiratory Distress Syndrome (ARDS): An Observational Study

“…Some studies associate positive fluid balance with development of ARDS. In an observational cohort study from 198 European ICUs reported that patients who subsequently developed ARDS received more fluids during the first four days of their ICU stay compared to patients who did not develop ARDS [19]. Thus, minimal positive fluid balance can be targeted in these patients.…”