High Thyroid-stimulating Hormone Levels Increase Proinflammatory and Cardiovascular Markers in Patients with Extreme Obesity

Gómez-Zamudio, Jaime; Mendoza‐Zubieta, Victoria; Ferreira‐Hermosillo, Aldo; Molina-Ayala, Mario; Valladares‐Salgado, Adán; Suárez‐Sánchez, Fernando; Peralta‐Romero, Jesús; Cruz, Miguel

doi:10.1016/j.arcmed.2016.10.007

Cited by 32 publications

(22 citation statements)

References 47 publications

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“…Among thyroid hormones, FT3 is cardioprotective. In euthyroid subjects, TSH is an independent predictor of cardiovascular disease [ 22 ]. FT4 is associated with differing metabolic markers [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Associations of Thyroid Hormone Levels with the Risk of Atherosclerosis in Euthyroid Type 2 Diabetic Patients in Central China

Wang

Chen

Yu³

et al. 2020

International Journal of Endocrinology

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Background. Thyroid function is associated with the etiology and pathogenesis of type 2 diabetes (T2D) and potentially contributes to the development of the complications of T2D. The association of thyroid hormones with atherosclerosis in euthyroid T2D patients is not clear. Purpose. To investigate the association of thyroid hormone levels with the risk of developing atherosclerosis in euthyroid T2D patients in Central China. Methods. This cross-sectional study recruited 910 euthyroid T2D patients from Henan Provincial People’s Hospital, China. Association among hemoglobin A1c (HbA1c), thyroid hormones, and the prevalence of atherosclerosis was assessed by multivariable Cox models after adjusting for covariates including age, BMI, duration of T2D, smoking status, SBP, TC, family history of T2D, and medications on hyperlipidemia. Results. Among all 910 subjects, 373 were diagnosed with atherosclerosis. There were 523 females and 387 males included in this study. The mean age was 51.9 years. The average BMI was 25.3 kg/m2. Low-normal serum-free triiodothyronine (FT3) levels (3.50–4.17 pmol/L) were associated with a high prevalence of atherosclerosis. Comparing with low-normal FT3, the prevalence ratio in patients with mid- (4.17–4.83 pmol/L) and high-normal FT3 level (4.83–6.50 pmol/L) is 0.74 (95% CI 0.56 to 0.97, p=0.029) and 0.63 (95% CI 0.46 to 0.87, p=0.005) after adjusting for covariates. High level of free thyroxine (FT4) also had decreased risk for atherosclerosis. Thyroid-stimulating hormone (TSH) and FT3 to FT4 ratio did not show significant association with the development of atherosclerosis. Conclusion. T2D patients with low but clinically normal FT3 level are more likely to develop macrovascular complications comparing with those with mid- and high-normal FT3 level.

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Section: Discussionmentioning

confidence: 99%

Clinical Associations of Thyroid Hormone Levels with the Risk of Atherosclerosis in Euthyroid Type 2 Diabetic Patients in Central China

Wang

Chen

Yu³

et al. 2020

International Journal of Endocrinology

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“…The reported data on the relationship between thyroid hormones and adiponectin are conflicting. Some authors reported a decreased adiponectin in hypothyroidism, others did not find significant differences to euthyroid persons [18,19]. The effects of thyroid hormones on adipose adiponectin gene expression in thyroid dysfunction remain unclear.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that under certain conditions adiponectin and leptin may have an additive effect [19]. It might be assumed the high adiponectin in hypothyroidism plays a compensatory role.…”

Section: Discussionmentioning

confidence: 99%

Role of Thyroid Deficiency on Adiponectin, Leptin, and Metabolic Status in Visceral Obesity: A Cross-Sectional Study

et al. 2017

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Hypothyroidism results in disturbances of metabolism influencing many regulatory systems and active molecules as adipocytokines. Objective of the study was to investigate leptin and adiponectin in patients with visceral obesity and hypothyroidism in relation to metabolic status, insulin resistance and systemic inflammation. A total of 118 patients (59 hypothyroid and 59 euthyroid) were enrolled divided into four age-matched groups according to body wеight (BMI) and thyroid function. Laboratory panel includes TSH, FT4, FT3 (CMIA), adiponectin and leptin (ELISA), IL- 6 (ECLIA), CRP, insulin, glucose, apolipoprotein B and lipoprotein (a) - Lp(a). Hypothyroid patients revealed significant positive correlations of TSH, adiponectin and Lp(a). Their medians of 10.4 mU/l, 12.5 µg/ml and 116.3 mg/l respectively were significantly higher than in euthyroid patients- 1.5 mU/l, 6.26 µg/ml and 32.0 mU/l (p < 0.0001). Leptin in both obese groups was significantly higher than in patients with normal weight. Leptin in hypothyroid patients was lower but not significant to euthyroid ones (9.7 ng/ml vs 13.4 ng/ml respectively, p = 0.16), correlated negatively to TSH and positively to CRP, IL-6, ApoB, Lp(a) and BMI. HOMA-IR and serum insulin at 120 min in OGTT were significantly higher in hypothyroid than in euthyroid patients independent of BMI (p < 0.001). Adiponectin, insulin resistance and chronic inflammation indices in hypothyroid patients correlated positively to TSH, BMI and atherogenic lipoproteins subclasses ApoB/Lp(a). Increased adiponectin in thyroid deficiency could be due to secondary resistance of adiponectin receptors or appeared as a compensatory pathogenetic factor in hypothyroidism.

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“…We can detect specific methylation sites as molecular biological indicators to predict tumor prognosis. 19,20 RNF180 plays an important role, as a tumor suppressor gene involved in various cellular biological processes, such as DNA repair, gene transcription, apoptosis, etc. 5 In our previous study, we found that the methylation rate of RNF180 promoter gradually increased with the severity of gastric mucosal lesions from gastritis, atrophy gastritis to GC.…”

Section: Discussionmentioning

confidence: 99%

<p>Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer</p>

Han¹,

Liu²,

Jing³

et al. 2020

CMAR

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Background: Ring finger protein 180 (RNF180) is a tumor suppressor gene regulated by promoter methylation. We previously demonstrated that the RNF180 promoter methylation could be a risk factor for gastric cancer (GC); and eight high-frequency hypermethylated CpG sites were associated with GC. However, it is not clear whether these key sites can affect gene expression and involve in prognosis. The aim of this study was to investigate the effects of above CpG sites on the gene expression and prognosis of GC. Patients and Methods: A total of 164 GC tissues were enrolled and followed up. Tissue samples were used for DNA and RNA isolation. Methylation status of RNF180 was detected using bisulfite sequencing PCR (BSP). Expression levels of RNF180 were detected using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR). JASPAR and PROMO databases were used to predict the transcription factors (TFs) binding to the CpG site. Results: The methylation in RNF180 promoter region increased and mRNA expression decreased in GC tissue. Correlation analysis revealed that the average methylation rate (AMR) and four CpG sites methylation rate were negatively related to RNF180 expression, including M3(−165) (Chr5:64165942), M5(−148)(Chr5:64,165,959), M7(−133)(Chr5:64,165,974) and M8(−130) (Chr5:64,165,977). Furthermore, the methylation rate of M5(−148)(Chr5:64,165,959) and M27 (−26)(Chr5:64,166,081) above 0.3 indicated poor prognosis (P M5 = 0.008, P M27 = 0.003, HR M5(−148) = 2.000 (1.201,3.332), HR M27(−26) =2.389 (1.336,4.271)), which could be independent factors of prognosis. Conclusion: By focusing on the methylation sites in the RNF180 promoter region, we identified two high-frequency methylation sites, M5(−148)(Chr5:64,165,959) and M27(−26) (Chr5:64,166,081), which could affect gene expression and predict the prognosis of GC. In the future, the possible molecular mechanism involved needs to be further studied.

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High Thyroid-stimulating Hormone Levels Increase Proinflammatory and Cardiovascular Markers in Patients with Extreme Obesity

Cited by 32 publications

References 47 publications

Clinical Associations of Thyroid Hormone Levels with the Risk of Atherosclerosis in Euthyroid Type 2 Diabetic Patients in Central China

Clinical Associations of Thyroid Hormone Levels with the Risk of Atherosclerosis in Euthyroid Type 2 Diabetic Patients in Central China

Role of Thyroid Deficiency on Adiponectin, Leptin, and Metabolic Status in Visceral Obesity: A Cross-Sectional Study

<p>Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer</p>

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