High‐throughput system for the thermostability analysis of proteins
Sae Ito,
Ryo Matsunaga,
Makoto Nakakido
et al.
Abstract:Thermal stability of proteins is a primary metric for evaluating their physical properties. Although researchers attempted to predict it using machine learning frameworks, their performance has been dependent on the quality and quantity of published data. This is due to the technical limitation that thermodynamic characterization of protein denaturation by fluorescence or calorimetry in a high‐throughput manner has been challenging. Obtaining a melting curve that derives solely from the target protein requires… Show more
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