High throughput synthesis and screening of new protein resistant surfaces for membrane filtration

Zhou, Mingyan; Liu, Hongwei; Kilduff, James E.; Langer, Robert; Anderson, Daniel G.; Belfort, Georges

doi:10.1002/aic.12104

Cited by 39 publications

(78 citation statements)

References 71 publications

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“…18,20 The thickness of the PES layer (before grafting) was 159 ± 31 nm in water and 45 ± 17 nm in isobutanol. The thickness after grafting was 208 ± 44 nm in water, but could not be measured accurately in isobutanol (Supporting Information Figure S4).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

New Class of Synthetic Membranes: Organophilic Pervaporation Brushes for Organics Recovery

et al. 2015

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Isolating and concentrating volatile organics such as fuels and intermediate chemicals from aqueous solutions is important for environmental synthesis and processing. We have prepared a new class of easy-to-synthesize polymeric membranes comprising hydrophobic brush-like structures as a selective layer, and have tested them using pervaporation of isobutanol from water. These brush structures were prepared by graft-induced polymerization of hydrophobic vinyl monomers from light-sensitive poly(ether sulfone) nanofiltration support membranes (grafting from) without initiating agents. Graft-induced tethered polymer chains with multiple C18 alkane side-chains out-performed the industry gold standard silicone rubber membrane with selectivities of α = 10.1 ± 0.9 and 6.7 ± 0.1, respectively, at comparable permeation fluxes of 0.7− 1.0 ± 0.1 L/m 2 -h. Preparation of these brush membranes is simpler and easier to scale-up than current methods of preparing asymmetric and composite membrane structures. These brush structures and this method of preparation have excellent potential for synthesizing selective membranes suitable for large-scale organic−water separations. ■ INTRODUCTIONPressure-driven membrane filtration processes have matured and are now widely accepted in many industries such as in energy, biotechnology, food and beverage, chemical, wastewater, gas fractionation, and desalination due to their low energy requirements and one-phase operation. Although membranes made from metals or ceramics are available, polymeric materials predominate. 1 For over 40 years, both interfacial polymerization 2 and phase inversion 3 have been the predominant methods for preparing composite polymeric and asymmetric membrane structures, respectively. Although these synthesis methods have been very successful, they are both relatively complex and sensitive to small changes in the casting conditions. 4 Many research groups have sought novel synthesis methods for producing synthetic membranes without much success. These membranes suffer from limitations including low porosity (track etched), 5−7 high cost (ceramic or stainless steel), 8 wide pore size distribution (stretched PTFE), 9−11 and low strength (biological), 12 or are difficult to scale-up (zeolite, carbon-nanotubes or graphene oxide). 13−15 Here, we synthesize a new class of synthetic brush hydrophobic polymer membranes, and then test them with a challenging separation: removal of isobutanol from water by pervaporation (PV). 16 To prepare the best performing hydrophobic brush membranes for this separation, we used our unique high throughput platform with 96 filter well plates. 17 The method of preparation involves grafting commercially available vinyl monomers alone or in mixtures to light-sensitive poly(ether sulfone) (PES) nanofiltration membranes, screening for the best performers, and selecting the winners. 18−20 The high throughput platform has also been used with combinatorial chemistry to generate a library of new monomers. 19,21 The newly synthesized hydrophobic-terminat...

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Section: ■ Results and Discussionmentioning

confidence: 99%

New Class of Synthetic Membranes: Organophilic Pervaporation Brushes for Organics Recovery

et al. 2015

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“…The magnitude of resistance was generally greater after protein solution filtration as compared with static adsorption, because resistance was developed by different mechanisms (e.g., during filtration, permeation drag causes mass accumulation on the membrane surface and in the mem- brane pores and may induce protein aggregation); still, the two approaches exhibited similar trends in measured resistance. Zhou et al [1][2][3] have identified several promising monomers with the high throughput platform. These monomers were tested in benchscale filtration experiments with mixing to assess the scalability of the results and whether surfaces that exhibited low protein interactions after adsorption would also be favorable for filtration applications.…”

Section: Discussionmentioning

confidence: 99%

“…What we urgently need is a fast, efficient and reproducible process to allow for quick selection of the best polymer, and subsequent analysis of its mechanism to find "rules" for future design of surfaces for membrane and other separations. We have recently developed and reported such a method in the literature, by adapting a high throughput platform (HTP) to the facile modification of commercial PES membranes, using HTP together with photo-induced graft polymerization (PGP) [1][2][3]. We call this method HTP-PGP.…”

Section: Introductionmentioning

confidence: 98%

“…The solvent must readily dissolve the monomer but not excessively swell the membrane. To date, we have used two solvents separately, DI water or 100% ethanol, to dissolve the 66 commercially available monomers [1][2][3]. Clearly, the efficacy of the method for selecting desired surfaces depends on the efficiency of grafting and polymerization and this in turn depends directly on the solubility of the selected monomers and the effect of the solvent on swelling the membrane [4,5,11].…”

Section: Introductionmentioning

confidence: 99%

“…We report here on the use of a high throughput platform and systematically vary binary mixtures (alcohol/water) to search for optimal conditions using previously identified monomers that exhibited excellent performance [1][2][3]. Four PEG and three amine vinyl monomers were chosen for this study and the solvent was varied using mixtures of alcohols.…”

Section: Introductionmentioning

confidence: 99%

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Searching for super protein-resistant synthetic membrane surfaces using high throughput: Solvent effects

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2011

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Molecular simulations on the hydration and underwater oleophobicity of zwitterionic self‐assembled monolayers

et al. 2020

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Zwitterionic materials have attracted increasing attentions in the underwater super‐oleophobic applications for its strong hydration via electrostatic interactions. Herein, molecular dynamics simulations were used to investigate the hydration and underwater oleophobicity of sulfobetaine‐terminated self‐assembled monolayers (SB‐SAMs) with different carbon spacer lengths (CSL) between oppositely charged groups of SB molecules. Simulation results show that the hydration of SB‐SAMs is positively dependent on CSL; the underwater oleophobicity is strengthened and then weakened with the increase of CSL, reaching optimal performance when CSL = 3; adhesion force of oil droplet on SB‐SAMs is inversely correlated with their contact angles, reaching the minimum value when CSL = 3. Moreover, the addition of NaCl can weaken the self‐association of SB molecules resulted from interactions between cationic and anionic groups, which promotes hydration and enhances underwater oleophobicity of SB‐SAMs. These results will benefit for the design of novel zwitterion‐based materials for anti‐fouling and oil–water separation applications.

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High throughput synthesis and screening of new protein resistant surfaces for membrane filtration

Cited by 39 publications

References 71 publications

New Class of Synthetic Membranes: Organophilic Pervaporation Brushes for Organics Recovery

New Class of Synthetic Membranes: Organophilic Pervaporation Brushes for Organics Recovery

Searching for super protein-resistant synthetic membrane surfaces using high throughput: Solvent effects

Molecular simulations on the hydration and underwater oleophobicity of zwitterionic self‐assembled monolayers

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