High-throughput screening for Cushing’s disease: therapeutic potential of thiostrepton via cell cycle regulation
Takuro Hakata,
Ichiro Yamauchi,
Daisuke Kosugi
et al.
Abstract:Cushing’s disease is a life-threatening disorder caused by autonomous secretion of adrenocorticotropic hormone (ACTH) from pituitary neuroendocrine tumors (PitNETs). Few drugs are indicated for inoperative Cushing’s disease, in particular that due to aggressive PitNETs. To explore agents that regulate ACTH-secreting PitNETs, we conducted high-throughput screening (HTS) using AtT-20, a murine pituitary tumor cell line characterized by ACTH secretion. For the HTS, we constructed a live cell– based ACTH reporter … Show more
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