High-throughput screening

Persidis, Aris

doi:10.1038/nbt0598-488

Cited by 66 publications

(40 citation statements)

References 7 publications

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“…[193,259] Access to key biological reagents unfortunately is sometimes a limiting factor for developing assays using biomolecules expressed by mammalian cell lines. [260] Together with scientists from Hoffman-La Roche, we developed a high-sensitivity, low-volume assay for the tumor necrosis factor a (TNF-a) using MFNs. [261] The assay format is a micromosaic immunoassay done using two-dimensional CSs (Fig.…”

Section: Low-volume and High-sensitivity Assaysmentioning

confidence: 99%

Microfluidics for Processing Surfaces and Miniaturizing Biological Assays

2005

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This review is an account of our efforts to develop a versatile and flexible microfluidic technology for surface‐processing applications and miniaturizing biological assays. The review is presented in the context of current trends in microfluidic technology and addresses some of the major challenges for confining chemical and biochemical processes on surfaces: the sealing of a microchannel with a surface, the world‐to‐chip interface, the displacement of liquids in small conduits, the sequential delivery of multiple solutions, the accurate patterning of surfaces, the coincident detection of various analytes, and the detection of analytes in a small and dilute sample. Our solutions to these problems include the use of reversible sealing, capillary phenomena for powering and controlling liquid transport, and non‐contact microfluidics for spotting and drawing (on surfaces) with flow conditions. These solutions offer many advantages over conventional techniques for handling minute amounts of liquids and may find applications in lithography, biopatterning (e.g., the patterning of biomolecules), diagnostics, drug discovery, and also cellular assays.

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Section: Low-volume and High-sensitivity Assaysmentioning

confidence: 99%

Microfluidics for Processing Surfaces and Miniaturizing Biological Assays

2005

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“…Fluorescence polarization high-throughput readers for microtiter plate formats are available since a few years (PERSIDIS, 1998). An increasing number of fluorescence polarization assays for drug discovery have been described (SPORTSMAN et al, 1997) and are commercially available.…”

Section: Hts)mentioning

confidence: 99%

New Methods of Screening in Biotechnology

Frobel¹,

Metzger²

2001

Biotechnology

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“…Using high-throughput screening [14] technology, for example, one can automatically analyze a large number of potential drug candidates, which allows researchers to do thousands of pharmacological, biological and chemical experiments in a short time. According to Schmidhuber [15], by 2040, machines will be sufficiently 'intelligent' to make scientists redundant.…”

Section: The Development Of Science Automationmentioning

confidence: 99%

A coevolutionary approach to learn animal behavior through controlled interaction

Gauci

Groß

2013

Proceedings of the 15th Annual Conference on Genetic and Evolutionary Computation

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This paper proposes a method that allows a machine to infer the behavior of an animal in a fully automatic way. In principle, the machine does not need any prior information about the behavior. It is able to modify the environmental conditions and observe the animal; therefore it can learn about the animal through controlled interaction. Using a competitive coevolutionary approach, the machine concurrently evolves animats, that is, models to approximate the animal, as well as classifiers to discriminate between animal and animat. We present a proof-of-concept study conducted in computer simulation that shows the feasibility of the approach. Moreover, we show that the machine learns significantly better through interaction with the animal than through passive observation. We discuss the merits and limitations of the approach and outline potential future directions.

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High-throughput screening

Cited by 66 publications

References 7 publications

Microfluidics for Processing Surfaces and Miniaturizing Biological Assays

Microfluidics for Processing Surfaces and Miniaturizing Biological Assays

New Methods of Screening in Biotechnology

A coevolutionary approach to learn animal behavior through controlled interaction

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