“…Such activation often arises from genetic alterations, either by mutation or by amplification of genes that have a pivotal role in the maintenance of cellular homeostasis. As such, genome-wide screening has been used extensively for the discovery of novel mutations in cell signalling molecules such as the tyrosine kinase superfamily to better understand the pathophysiology of cancers and to identify new drug targets (Bardelli et al, 2003;Stephens et al, 2004Stephens et al, , 2005Bignell et al, 2006;Greenman et al, 2007;Ruhe et al, 2007;Thomas et al, 2007). However, a major constraint in this process is the difficulty in establishing the functional significance of newly discovered genetic lesions for cancer formation and progression.…”