High-Throughput Nanoflow Proteomics Using a Dual-Column Electrospray Source
An Staes,
Katie Boucher,
Sara Dufour
et al.
Abstract:With current trends in proteomics, especially regarding
clinical
and low input (to single cell) samples, it is increasingly important
to both maximize the throughput of the analysis and maintain as much
sensitivity as possible. The new generation of mass spectrometers
(MS) are taking a huge leap in sensitivity, allowing analysis of samples
with shorter liquid chromatography (LC) methods while digging as deep
in the proteome. However, the throughput can be doubled by implementing
a dual column nano-LC-MS config… Show more
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