2006
DOI: 10.2174/157018006777805530
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High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis

Abstract: In the last five years we prepared and studied some dialkylaminoalkylnaphthalenes and cycloaminoalkylnaphthalenes with interesting opioid-like analgesic activity. In this paper we report on their lipophilicity evaluation combining computational and RP-HPLC experiments. A suitable computational method for the high-throughput log P screening was identified.

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