High-throughput label-free detection of Ochratoxin A in wine using supported liquid membrane extraction and Ag-capped silicon nanopillar SERS substrates

Rostami, Simindokht; Zór, Kinga; Zhai, Demi Shuang; Viehrig, Marlitt; Morelli, Lidia; Mehdinia, Ali; Smedsgaard, Jørn; Rindzevicius, Tomas; Boisen, Anja

doi:10.1016/j.foodcont.2020.107183

Cited by 30 publications

(29 citation statements)

References 57 publications

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“…This combination made possible the study of mycotoxins by CZE-UV, by simply using a neutral pH BGE with a small addition of βCD, eliminating matrix interference and offering a rapid and simple clean up with high selectivity. The pre-concentration procedure allowed sensitivity values higher (30 μg/Kg) than those obtained with the most recent optimizations of SLM procedures, combined with different analytical approaches, such as Surface-Enhanced Raman Spectroscopy (SERS) or HPLC-MS [ 57 ].…”

Section: Sample Preparation For Ce Analysismentioning

confidence: 99%

Pre-Concentration and Analysis of Mycotoxins in Food Samples by Capillary Electrophoresis

Colombo

Papetti

2020

Molecules

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Mycotoxins are considered one of the most dangerous agricultural and food contaminants. They are toxic and the development of rapid and sensitive analytical methods to detect and quantify them is a very important issue in the context of food safety and animal/human health. The need to detect mycotoxins at trace levels and to simultaneously analyze many different mycotoxin types became mandatory to protect public health. In fact, European Commission regulations specified both their limits in foodstuffs and official sample preparation protocols in addition to analytical methods to verify their presence. Capillary Electrophoresis (CE) includes different separation modes, allowing many versatile applications in food analysis and safety. In the context of mycotoxins, recent advances to improve CE sensitivity, particularly pre-concentration techniques or miniaturized systems, deserve remarkable attention, as they provide an interesting approach in the analysis of such contaminants in complex food matrices. This review summarizes the applications of CE combined with different pre-concentration approaches, which have been proposed in the literature (mainly) in the last ten years. A section is also dedicated to recent microchip–CE devices since they represent the most promising CE mode for this application.

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Section: Sample Preparation For Ce Analysismentioning

confidence: 99%

Pre-Concentration and Analysis of Mycotoxins in Food Samples by Capillary Electrophoresis

Colombo

Papetti

2020

Molecules

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“…Compared with the traditional immunoaffinity column, SLM extraction shows the advantages of high recovery efficiency, low solvent consumption and user‐friendly operating procedure. Therefore, SLM combined with SERS (SLM‐SERS) had been applied for rapidly detecting OTA in wines (see Figure 8B) (Rostami et al., 2020). Due to the complexity of wine samples, the presence of matrix interference in wines would lead to the absence of SERS signal of OTA.…”

Section: Sers Combined With Other Techniquesmentioning

confidence: 99%

“…F I G U R E 8 (a) Schematic illustration of AFs detection using TLC-SERS (L. L. Qu et al, 2018). (b) Schematic illustration of OTA extraction with SLM and SERS-based detection (top); SEM image of Ag-capped silicon nanopillar array and photo image of multiwell system with incorporated SERS chip (Rostami et al, 2020). (c) Schematic illustration of SERS-based lateral flow immunosensor for the detection of multiple mycotoxins (W. SLM extraction is based on a single mass-transfer step, driven by the pH difference between two aqueous phases, separated by a hydrophobic organic solvent impregnated in a porous membrane.…”

Section: Separation Techniquesmentioning

confidence: 99%

“…(a) Schematic illustration of AFs detection using TLC‐SERS (L. L. Qu et al., 2018). (b) Schematic illustration of OTA extraction with SLM and SERS‐based detection (top); SEM image of Ag‐capped silicon nanopillar array and photo image of multiwell system with incorporated SERS chip (Rostami et al., 2020). (c) Schematic illustration of SERS‐based lateral flow immunosensor for the detection of multiple mycotoxins (W. Zhang et al., 2020)…”

Section: Sers Combined With Other Techniquesmentioning

confidence: 99%

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Recent progress in mycotoxins detection based on surface‐enhanced Raman spectroscopy

Zhai

You

Ouyang

et al. 2021

Comp Rev Food Sci Food Safe

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Mycotoxins are toxic compounds naturally produced by certain types of fungi. The contamination of mycotoxins can occur on numerous foodstuffs, including cereals, nuts, fruits, and spices, and pose a major threat to humans and animals by causing acute and chronic toxic effects. In this regard, reliable techniques for accurate and sensitive detection of mycotoxins in agricultural products and food samples are urgently needed. As an advanced analytical tool, surface‐enhanced Raman spectroscopy (SERS), presents several major advantages, such as ultrahigh sensitivity, rapid detection, fingerprint‐type information, and miniaturized equipment. Benefiting from these merits, rapid growth has been observed under the topic of SERS‐based mycotoxin detection. This review provides a comprehensive overview of the recent achievements in this area. The progress of SERS‐based label‐free detection, aptasensor, and immunosensor, as well as SERS combined with other techniques, has been summarized, and in‐depth discussion of the remaining challenges has been provided, in order to inspire future development of translating the techniques invented in scientific laboratories into easy‐to‐operate analytic platforms for rapid detection of mycotoxins.

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“…The ingestion of these metabolites is a potential threat to humans and animals. (1) Among these metabolites, ochratoxin A (OTA) is one of the most common and harmful substances, (2) and is nephrotoxic, immunosuppressive, and carcinogenic. (3) Hence, a sensitive and efficient analytical method is required for its determination.…”

Section: Introductionmentioning

confidence: 99%

Novel Photothermal Aptamer-based Sensing System for Highly Ultrasensitive Detection of Ochratoxin A

Qin¹,

Guan²,

Qiu³

2021

Sensors and Materials

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High-throughput label-free detection of Ochratoxin A in wine using supported liquid membrane extraction and Ag-capped silicon nanopillar SERS substrates

Cited by 30 publications

References 57 publications

Pre-Concentration and Analysis of Mycotoxins in Food Samples by Capillary Electrophoresis

Pre-Concentration and Analysis of Mycotoxins in Food Samples by Capillary Electrophoresis

Recent progress in mycotoxins detection based on surface‐enhanced Raman spectroscopy

Novel Photothermal Aptamer-based Sensing System for Highly Ultrasensitive Detection of Ochratoxin A

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