High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus
Qiang Wang,
Taehyeung Kim,
Marta Martínez-Bonet
et al.
Abstract:Genome-wide association studies implicate multiple loci in risk for systemic lupus erythematosus (SLE), but few contain exonic variants, rendering systematic identification of non-coding variants essential to decoding SLE genetics. We utilized SNP-seq and bioinformatic enrichment to interrogate 2180 single-nucleotide polymorphisms (SNPs) from 87 SLE risk loci for potential binding of transcription factors and related proteins from B cells. 52 SNPs that passed initial screening were tested by electrophoretic mo… Show more
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