High-throughput determination of oxidative stress biomarkers in saliva by solvent-assisted dispersive solid-phase extraction for clinical analysis

Peris-Pastor, Guillem; Alonso-Rodríguez, Sandra; Benedé, Juan L.; Chisvert, Alberto

doi:10.1016/j.sampre.2023.100067

Cited by 1 publication

(1 citation statement)

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“…In recent years, the application of biomarkers in patient status diagnosis and management has become a growing method, and the development of molecular biology has led to the continuous discovery of new circulating biomarkers [ 10 , 11 ]. At the same time, molecular epidemiological studies have also confirmed the relationship between oxidative stress and carcinogens [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Sensing System for 8-OHdG Detection Based on Plasma Coupled Electrochemistry by Transparent ITO/AuNTAs/PtNPs Electrode

Bai

2023

Biosensors

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8-Hydroxydeoxyguanosine (8-OHdG) is the most widely used oxidative stress biomarker of the free radical-induced oxidative damage product of DNA, which may allow a premature assessment of various diseases. This paper designs a label-free, portable biosensor device to directly detect 8-OHdG by plasma-coupled electrochemistry on a transparent and conductive indium tin oxide (ITO) electrode. We reported a flexible printed ITO electrode made from particle-free silver and carbon inks. After inkjet printing, the working electrode was sequentially assembled by gold nanotriangles (AuNTAs) and platinum nanoparticles (PtNPs). This nanomaterial-modified portable biosensor showed excellent electrochemical performance for 8-OHdG detection from 10 μg/mL to 100 μg/mL by our self-developed constant voltage source integrated circuit system. This work demonstrated a portable biosensor for simultaneously integrating nanostructure, electroconductivity, and biocompatibility to construct advanced biosensors for oxidative damage biomarkers. The proposed nanomaterial-modified ITO-based electrochemical portable device was a potential biosensor to approach 8-OHdG point-of-care testing (POCT) in various biological fluid samples, such as saliva and urine samples.

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Section: Introductionmentioning

confidence: 99%

Oxidative Stress Sensing System for 8-OHdG Detection Based on Plasma Coupled Electrochemistry by Transparent ITO/AuNTAs/PtNPs Electrode

Bai

2023

Biosensors

View full text Add to dashboard Cite

show abstract

High-throughput determination of oxidative stress biomarkers in saliva by solvent-assisted dispersive solid-phase extraction for clinical analysis

Cited by 1 publication

References 36 publications

Oxidative Stress Sensing System for 8-OHdG Detection Based on Plasma Coupled Electrochemistry by Transparent ITO/AuNTAs/PtNPs Electrode

Oxidative Stress Sensing System for 8-OHdG Detection Based on Plasma Coupled Electrochemistry by Transparent ITO/AuNTAs/PtNPs Electrode

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