High‐Throughput Contact Flow Lithography

Goff, Gaelle C. Le; Lee, Jiseok; Gupta, Ankur; Hill, W. A.; Doyle, Patrick S.

doi:10.1002/advs.201500149

Cited by 52 publications

(43 citation statements)

References 44 publications

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“…Researchers interested in parallel experimentation for diagnostic research may also find this platform useful for creating several isolated aqueous pockets. Moreover, our platform can be easily adapted for large-scale phtopatterning and advanced microscopy techniques that allow this platform to be used for existing material synthesis methods [37]. For applications in designing liquid-infused surfaces, our results could provide design principles for successful entrapment of liquid layers.…”

Section: Discussionmentioning

confidence: 99%

Controlled liquid entrapment over patterned sidewalls in confined geometries

2017

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Liquid entrapment over patterned surfaces has applications in diagnostics, oil recovery, and printing processes. Here we study the process of oil displacement upon sequential injection of water over a photopatterned structure in a confined geometry. By varying the amplitude and frequency of triangular and sinusoidal patterns, we are able to completely remove oil or trap oil in varying amounts. We present a theoretical model based on geometrical arguments that successfully predicts the criterion for liquid entrapment and provides insights into the parameters that govern the physical process.

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Section: Discussionmentioning

confidence: 99%

Controlled liquid entrapment over patterned sidewalls in confined geometries

2017

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“…1c), and stored in aqueous solution. The particle synthesis throughput can be increased two orders of magnitude by using contact flow lithography 18 , which is an advanced form of SFL. To show the widespread potential of our platform, we synthesized and assembled various microparticles from two very different sets of prepolymer solutions.…”

Section: Design Principles For Lsmamentioning

confidence: 99%

Porous microwells for geometry-selective, large-scale microparticle arrays

et al. 2016

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Large-scale microparticle arrays (LSMA) are key for material science and bioengineering applications. However, previous approaches suffer from tradeoffs between scalability, precision, specificity, and versatility. Here, we present a porous microwell-based approach to create large-scale microparticle arrays with complex motifs. Microparticles are guided to and pushed into microwells by fluid flow through small open pores at the bottom of the porous well arrays. A scaling theory allows for the rational design of LSMAs to sort and array particles based on their size, shape or modulus. Sequential particle assembly allows for proximal and nested particle arrangements, as well as particle recollection and pattern transfer. We demonstrate the capabilities of the approach by means of three applications: high-throughput single-cell arrays; microenvironment fabrication for neutrophil chemotaxis; and complex, covert tags by the transfer of an upconversion nanocrystal laden LSMA.

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“…7 In the system, collimated illumination, generated by a high power UV light-emitting diode (LED), exposes eight channels (950 μm × 10 mm) simultaneously through a photomask in direct contact with the microfluidic device. 7 In the system, collimated illumination, generated by a high power UV light-emitting diode (LED), exposes eight channels (950 μm × 10 mm) simultaneously through a photomask in direct contact with the microfluidic device.…”

Section: Injectable Microporous Gels Formed From Microfluidically-genmentioning

confidence: 99%

Research highlights: microfluidically-fabricated materials

Koh

Kittur

et al. 2015

Lab Chip

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Polymer particles with precise shapes or chemistries are finding unique uses in a variety of applications, including tissue engineering, drug delivery, barcoding, and diagnostic imaging. Microfluidic systems have been and are continuing to play a large role in enabling the precision synthesis of designer particles in a uniform manner. To expand the impact of these microfluidic-fabricated materials additional fundamental capabilities should still be developed. The capability to fabricate microparticles with complex three-dimensional shapes and increase the production rate of particles to an industrial scale will allow evaluation of shaped particles in a range of new applications to enhance biological, magnetic, optical, surface wetting, as well as other interfacial or mechanical properties of materials. Here we highlight work applying large collections of simple spherical microgels, with unique surface chemistry that allows in situ particle-particle annealing, to form microporous injectable scaffolds for accelerated tissue regeneration. We also report on two other techniques that are addressing the ability to create 3D-shaped microparticles by first sculpting a fluid precursor stream, and increasing the rate of production of particles using contact lithography to millions of particles per hour. The combination of these capabilities and the applications they will enable suggest a bright future for microfluidics in making the next materials.

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High‐Throughput Contact Flow Lithography

Cited by 52 publications

References 44 publications

Controlled liquid entrapment over patterned sidewalls in confined geometries

Controlled liquid entrapment over patterned sidewalls in confined geometries

Porous microwells for geometry-selective, large-scale microparticle arrays

Research highlights: microfluidically-fabricated materials

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