High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfotiamine

Frank, Thomas; Bitsch, Roland; Maiwald, J.; Stein, Günter

doi:10.1007/s002280000131

Cited by 28 publications

(18 citation statements)

References 13 publications

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“…Other pharmacologic forms of thiamine may be moreefficiently absorbed (7,13,14), but we administered thiamine hydrochloride because it is readily available in Cambodia and appears on the WHO's model list of essential medications (15). Nonpharmacologic dietary thiamine supplementation might result in different pharmacokinetics.…”

Section: Discussionmentioning

confidence: 99%

Thiamine pharmacokinetics in Cambodian mothers and their breastfed infants

Coats¹,

Frank²,

Reid³

et al. 2013

The American Journal of Clinical Nutrition

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Section: Discussionmentioning

confidence: 99%

Thiamine pharmacokinetics in Cambodian mothers and their breastfed infants

Coats¹,

Frank²,

Reid³

et al. 2013

The American Journal of Clinical Nutrition

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“…Finally, in vitro studies that have compared thiamine to thiamine derivatives have generally found them to have similar effects [33-38]. In studies where a thiamine derivative was thought to be superior to thiamine hydrochloride, the difference could be completely explained by differences in bioavailability [39-41]. …”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects

2012

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BackgroundHigh dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses in healthy subjects.MethodsThis was a randomized, double-blind, single-dose, 4-way crossover study. Pharmacokinetic measures were calculated.ResultsThe AUC0-10 hr and Cmax values increased nonlinearly between100 mg and 1500 mg. The slope of the AUC0-10 hr vs dose, as well as the Cmax vs dose, plots are steepest at the lowest thiamine doses.ConclusionOur study demonstrates that high blood levels of thiamine can be achieved rapidly with oral thiamine hydrochloride. Thiamine is absorbed by both an active and nonsaturable passive process.Trial RegistrationClinicalTrials.gov: NCT00981877

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“…It has been reported that diabetic patients have an abnormal transketolase activity in peripheral tissues [37]. Previous reports hypothesized that boosting thiamine levels in diabetic patients might prevent activation of major pathways of hyperglycemic damage [16,38].…”

Section: Discussionmentioning

confidence: 98%