High Tension Versus Normal Tension Glaucoma. A Comparison of Structural and Functional Examinations

Lešták, Jan; Nutterova, Elena; Pitrová, S; Krejcová, H; Bartosová, L; Forgacova, Vera

doi:10.4172/2155-9570.s5-006

Cited by 18 publications

(8 citation statements)

References 10 publications

(10 reference statements)

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“…Based on these examinations, we came to the conclusion that, unlike NTG, hypertensive glaucoma damages the entire visual path. In NTG we found a relatively normal response of the retinal ganglion cells but with significant changes in the visual path 16 .…”

Section: Brief Overviewmentioning

confidence: 62%

Normotensive glaucoma

Lešták¹,

Jirásková²,

Žáková³

et al. 2018

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Section: Brief Overviewmentioning

confidence: 62%

Normotensive glaucoma

Lešták¹,

Jirásková²,

Žáková³

et al. 2018

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“…In normotensive glaucoma (NTG) the retinal ganglion cells are relatively intact. The pathology is in the level of ganglion fibres 5 . The unanswered question is what has altered ganglion cell fibres at the level of the retina and optic nerve head in NTG?…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma

et al. 2021

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Background. Hypertensive glaucoma (HTG) causes damage to the retinal ganglion cells and eventually to the entire visual pathway due to high intraocular pressure (IOP). However, increased IOP will also affect the vessel density (VD) of the posterior pole of the eye and the related retinal ganglion nerve fibres (RNFL). In normotensive glaucoma (NTG), the retinal ganglion cells are relatively intact. The pathology is at the level of ganglion fibres. The unanswered question is what has altered ganglion cell fibres at the level of the retina and optic nerve head in NTG? Aim. The aim of this study was to determine whether there is a correlation between the retinal nerve fibre layer (RNFL) and vessel density (VD) at the same altitudinal half of the retina and the sum of sensitivities of the contralateral half of the visual field of the same eye in hypertensive and normotensive glaucoma (NTG). Methods. Our group included 20 patients with HTG and 20 patients with NTG. The Pearson's correlation coefficient r was used for evaluation of the relationship of the peripapillary RNFL and VD, visual field (using the fast threshold glaucoma program) as the sum of sensitivities in apostilbs (asb) to the extent of 0-22 degrees. The results of sensitivity were compared with the RNFL and VD of the contralateral altitudinal half of the retina in the same eye. Results. In the HTG group there was a moderate relationship between RNFL and VD (both hemifields), but no relationship between RNFL and VF. VD SH and VF IH showed weak correlation and VD IH and VF SH showed no correlation. In patients with NTG, we found a strong correlation between RNFL and VD (both hemifields), between VD SH and VF IH a moderate correlation, between VD IH and VF SH also a moderate correlation and a weak correlation between RNFL and VF. Conclusion. By comparing the RNFL and VD at the same altitudinal halves of the retina, we found a moderate correlation in HTG and a strong correlation in NTG. We found no or a weak correlation between VD and VF in HTG. In NTG the relationship between VD and VF showed a strong correlation. These findings reveal the differences in the diagnostic groups.

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“…This so-called transsynaptic degeneration is espoused by Duncan et al 24,25 as well. In normal tension glaucoma there is no direct retinal ganglion cell damage 34 . The pathology is mainly in the visual pathway.…”

Section: Discussionmentioning

confidence: 99%

Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma

Lešták¹,

Tintěra²,

Svata³

et al. 2014

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Aim. The objective of our work was to determine whether there is a difference in fMRI activation between patients with high tension glaucoma (HTG) and those with normal tension glaucoma (NTG). Method. The sample consisted of eight patients with different stages of high tension glaucoma (3 females aged 41-65 and 5 males aged 40-73 years) and eight patients, also with different stages of normal tension glaucoma (6 females aged 53-70 and 2 males aged 40-52 years). The control group consisted of eight healthy subjects (3 females aged 23-46 and 5 males aged 23-65 years). All underwent complete ophthalmological examination, including visual field, colour vision, and electrophysiological functions. The results were compared with fMRI images after stimulation with black/white (BW) and blue/yellow (BY) checkerboard and then statistically processed. Results. The authors analyzed the results of published studies on high tension versus normal tension glaucoma in the images obtained by fMRI. They concluded on the basis of electrophysiological examinations that in high tension glaucoma, damage of the whole visual pathway occurs, starting from retinal ganglion cells up to the visual cortex. In normal tension glaucoma the response of ganglion cells is relatively normal. The pathology is found mainly in the visual pathway. For this reason, the authors carried out fMRI examinations in high tension glaucoma patients and patients with normal tension glaucoma. They found that advancing stages of high tension glaucoma cause progression of fMRI activity decrease. These relations were not observed in normal tension glaucoma cases. Similarly, in high tension glaucoma on fMRI examination to yellow/blue stimuli, the fMRI activity decrease was found to be greater than that to black/white stimulation. No similar effect was observed in normal tension glaucoma. Conclusion. Normal tension glaucoma is, from the etiopathogenetical view, a different disease than high tension glaucoma.

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High Tension Versus Normal Tension Glaucoma. A Comparison of Structural and Functional Examinations

Cited by 18 publications

References 10 publications

Normotensive glaucoma

Normotensive glaucoma

Optical coherence tomography angiography and the visual field in hypertensive and normotensive glaucoma

Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma

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