High Temporal Resolution Measurements of Dopamine with Carbon Nanotube Yarn Microelectrodes

Jacobs, Christopher B.; Ivanov, Ilia N.; Nguyen, Michael; Zestos, Alexander G.; Venton, B. Jill

doi:10.1021/ac404050t

Cited by 99 publications

(150 citation statements)

References 62 publications

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“…Researchers have found that ferric hydroxide-Nafion film-coated carboxylic acid-modified carbon nanotubes changed dopamine in drosophila [40]. Functionalization of carbon nanotubes with poly (diallyl dimethylammonium chloride) (PDDA) reduced the detection limit of dopamine [41] .…”

Section: Advances In the Therapeutic Effects Of Carbon Nanotubes On Mmentioning

confidence: 99%

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

Wang¹,

Xue²

2017

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Abstract:Nervous system diseases, such as Alzheimer's disease, stroke, and Parkinson's disease, are spreading around the world. These diseases involve complicatedly pathological processes, and so far, there are no effective medicines for therapy. Another type of psychiatric disorder is induced by drugs. The synthetic drugs, represented by methamphetamine, are becoming widely abuse. At present, the cure of methamphetamine dependence is mainly symptomatic treatment, but the recurrence rate is very high. As the common brain impairments in neuropsychiatric disease, it is necessary to summary novel strategies effectively restored brain function. In recent years, carbon nanotubes have attracted the attention due to their unique properties in the field of translational medicine. Recently, new advances reported that carbon nanotubes as a nanomedicine to treat various neuropsychiatric disorders. The purpose of this review is to introduce the therapeutic approaches and mechanisms of carbon nanotubes on neuropsychiatric disorders.

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Section: Advances In the Therapeutic Effects Of Carbon Nanotubes On Mmentioning

confidence: 99%

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

Wang¹,

Xue²

2017

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“…CNT yarns are made of multiple CNT fibres twisted together and these have been utilized by Yang and team for production of CNT yarn microelectrodes (CNTYMEs). The CNTYMEs are used for speedy measurements of dopamine [85]. CNTs can be used to determine the level of disease severity and other pathological conditions.…”

Section: Carbon Nanotubes As Electrochemical Biosensors In Neurosciencementioning

confidence: 99%

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Komane

Choonara

Toit

et al. 2016

Journal of Nanomaterials

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Extensive research on carbon nanotubes has been conducted due to their excellent physicochemical properties. Based on their outstanding physicochemical properties, carbon nanotubes have the potential to be employed as theranostic tools for neurological pathologies such as Alzheimer’s disease and Parkinson’s disease including ischemic stroke diagnosis and treatment. Stroke is currently regarded as the third root cause of death and the leading source of immobility around the globe. The development and improvement of efficient and effective procedures for central nervous system disease diagnosis and treatment is necessitated. The main aim of this review is to discuss the application of nanotechnology, specifically carbon nanotubes, to the diagnosis and treatment of neurological disorders with an emphasis on ischemic stroke. Areas covered include the conventional current diagnosis and treatment of neurological disorders, as well as a critical review of the application of carbon nanotubes in the diagnosis and treatment of ischemic stroke, covering areas such as functionalization of carbon nanotubes and carbon nanotube-based biosensors. A broad perspective on carbon nanotube stimuli-responsiveness, carbon nanotube toxicity, and commercially available carbon nanotubes is provided. Potential future studies employing carbon nanotubes have been discussed, evaluating their extent of advancement in the diagnosis and treatment of neurological and ischemic disorders.

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“…Our group utilized a commercially-available CNT yarn fabricated microelectrodes for dopamine detection with LOD of 13 ± 2 nM. 93 We also found the dopamine signal is independent to the repetition rate with FSCV at CNT yarn microelectrodes, an advantage over conventionally used CFMEs which lose sensitivity with increasing repetition rate ( Fig. 1.2).…”

Section: Carbon Nanotube-fiber Microelectrodesmentioning

confidence: 83%

“…138,139 Our group has recently discovered that at CNTYMEs, the dopamine current does not change significantly with increasing scan repetition frequency: at a scan rate of 2000 V/s, dopamine can be detected, without any loss in sensitivity, with scan frequencies up to 500 Hz. 93 Thus, the temporal resolution is four times faster without a decrease in signal. The cause of this increased temporal resolution is differences in dopamine and DOQ adsorption and desorption kinetics; at CNTYMEs, the rates of desorption for dopamine and DOQ are almost identical, while at CFMEs, the rate of desorption for DOQ is over an order of magnitude higher than that for dopamine.…”

Section: Yang| 26mentioning

confidence: 97%

“…90 The first electrochemical application of a CNT fiber sensor was reported in 2003 91 and CNT fiber microelectrodes have been developed for dopamine detection using DPV 92 , chronoamperometry 89 , and FSCV. 93,94 Two distinct routes have been developed for manufacturing CNT fibers: wet-spinning a suspension of CNTs into a bath or direct spinning a fiber from a CNT forest. In solution based wet spinning, CNTs are either dissolved or dispersed in a fluid, extruded out of a spinneret, and coagulated into a solid fiber by extracting the dispersant.…”

Section: Carbon Nanotube-fiber Microelectrodesmentioning

confidence: 99%

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Development of Electrochemical Microsensors for in vivo Neurotransmitter Detection

Yang

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Everything that happens in our body and all the interactions we have with the outside world are controlled by our brain. Studies of neurotransmitters are critical for a better understanding of how our brain works. Fast-scan cyclic voltammetry (FSCV) is the most popular electrochemical technique for the in vivo detection of electroactive neurotransmitters and neurochemicals with high temporal resolution. To further improve the detection selectivity, sensitivity, and spatial resolution, carbon nanomaterial based microelectrodes are applied to enhance FSCV for the neurotransmitters detection. In this thesis, I introduce and discuss synthesis and fabrication of several novel carbon nanomaterials, the effect of different surface modifications, and their applications for in vivo neurotransmitter detection.Chapter 1 covers the recent advances in carbon nanomaterial based electrochemical sensors for direct neurotransmitter detection. First, strategies are compared to incorporate carbon nanomaterials into electrochemical sensors for neurotransmitter detection. Second, several new applications are highlighted as well as studies to address the remaining challenges for implementation. Chapters 2-5 describe new carbon nanomaterials and surface treatments for enhanced neurotransmitter detection. The direct growth of CNTs on metal wires is introduced in Chapter 2. Chapter 3 and Chapter 4 introduce three surface modification methods, laser treatment, O2 plasma etching, and anti-static gun treatment, to improve sensitivity, selectivity, and bio-fouling properties on CNT yarn microelectrodes. In Chapter 5, three different types of CNT fiber materials, CNT yarn, PEI/CNT fiber, and CA/CNT fiber, are introduced and compared for the detection of neurotransmitters. Surface physical properties and the electrochemical performance to neurotransmitters are characterized in these studies and correlated using Langmuir adsorption isotherm and diffusion profiles. Moreover, in vivo measurements are performed for dopamine at CNT-Nb microelectrodes and laser treated CNT yarn microelectrodes in Chapter 2 and Chapter 3. The effect of bio-fouling on CNT yarn is discussed in Chapter 4. Yang| iiChapter 6 and Chapter 7 introduce two novel electrode fabrication methods based on 3D printing: a 3D printed mold assisted microelectrode fabrication method and a novel 3D printed electrode design for fiber-like materials. The 3D printing technology with low-cost, high efficiency, and customizable design provides a new path to apply our studies on novel fiber-like carbon nanomaterials and surface modifications to broader applications.Overall, this thesis explores the synthesis and fabrication of several novel carbon nanomaterials, the effect of different surface modifications, and their applications for in vivo neurotransmitters detection. Moreover, the electrode surface properties are also characterized and then correlated to their electrochemical performance. The systematic comparison of different carbon nanomaterials and different surface modificati...

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High Temporal Resolution Measurements of Dopamine with Carbon Nanotube Yarn Microelectrodes

Cited by 99 publications

References 62 publications

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

Diagnosis and Treatment of Neurological and Ischemic Disorders Employing Carbon Nanotube Technology

Development of Electrochemical Microsensors for in vivo Neurotransmitter Detection

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