High temperature stress response is not sexually dimorphic at the whole-body level and is dependent on androgens to induce sex reversal

Castañeda-Cortés, Diana C; Zhang, Jing; Boan, Agustín F.; Langlois, Valérie S.; Fernandino, Juan Ignacio

doi:10.1016/j.ygcen.2020.113605

Cited by 10 publications

(2 citation statements)

References 86 publications

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“…In the context of global warming, the low sensitivity to TH at warm temperature is a concern because it may reduce the capacity of zebrafish to match this environmental change. Furthermore, in medaka, exposure until hatching to warm temperatures (32 • C) increases the activation of TH biosynthesis, via TSH (Castañeda- Cortés et al, 2020), as well as the activation of the stress axis, via CRH (Castañeda- Cortés et al, 2019).…”

Section: Water Warming For Population Strictly Dependent On An Aquatic Habitatmentioning

confidence: 99%

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

2021

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Post-embryonic acute developmental processes mainly allow the transition from one life stage in a specific ecological niche to the next life stage in a different ecological niche. Metamorphosis, an emblematic type of these post-embryonic developmental processes, has occurred repeatedly and independently in various phylogenetic groups throughout metazoan evolution, such as in cnidarian, insects, molluscs, tunicates, or vertebrates. This review will focus on metamorphoses and developmental transitions in vertebrates, including typical larval metamorphosis in anuran amphibians, larval and secondary metamorphoses in teleost fishes, egg hatching in sauropsids and birth in mammals. Two neuroendocrine axes, the hypothalamic-pituitary-thyroid and the hypothalamic-pituitary-adrenal/interrenal axes, are central players in the regulation of these life transitions. The review will address the molecular and functional evolution of these axes and their interactions. Mechanisms of integration of internal and environmental cues, and activation of these neuroendocrine axes represent key questions in an “eco-evo-devo” perspective of metamorphosis. The roles played by developmental transitions in the innovation, adaptation, and plasticity of life cycles throughout vertebrates will be discussed. In the current context of global climate change and habitat destruction, the review will also address the impact of environmental factors, such as global warming and endocrine disruptors on hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal/interrenal axes, and regulation of developmental transitions.

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Section: Water Warming For Population Strictly Dependent On An Aquatic Habitatmentioning

confidence: 99%

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

2021

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“…Higher temperatures have been shown to increase plasma cortisol levels in sh [5][6][7] through activation of the brain-pituitary-interrenal axis [8], which promotes androgen synthesis [9,10]. Although the involvement of stress in heat-induced masculinization has been characterized in recent years, the endocrine and molecular processes controlling gonadal sex change are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Thyroid axis participates in heat temperature-induced male sex reversal through its activation by the stress response

Castañeda-Cortés

Rosa

Boan

et al. 2023

Preprint

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Environmental changes alter the sex fate in about 15% of vertebrate orders, mainly in ectotherms such as fish and reptiles. However, the effects of temperature changes on the endocrine and molecular processes controlling gonadal sex determination are not fully understood. Here, we provide evidence that thyroid hormones (THs) act as co-players in heat-induced masculinization through interactions with the stress axis to promote testicular development. We first demonstrated that the thyroid axis (through thyroid-related genes and T3 levels) is highly active in males during the gonadal development in medaka (Oryzias latipes). Similarly, T3 treatments promoted female-to-male sex reversal in XX embryos. Subsequently, embryonic exposure to temperature-induced stress up-regulated the genes related to the thyroid and stress axes with a final increase in T3 levels. In this context, we show that blocking the stress axis response by the loss of function of the corticotropin-releasing hormone receptors suppresses thyroid-stimulating hormone expression, therefore, heat-induced activation of the thyroid axis. Thus, our data showed that early activation of the stress axis and, in consequence, the TH axis, too, leaves us with that both are the leading endocrine players in inducing female-to-male reversal, which can help predict possible upcoming physiological impacts of global warming on fish populations.

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Thyroid axis participates in high-temperature-induced male sex reversal through its activation by the stress response

Castañeda-Cortés,

Rosa,

Boan

et al. 2023

Cell. Mol. Life Sci.

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High temperature stress response is not sexually dimorphic at the whole-body level and is dependent on androgens to induce sex reversal

Cited by 10 publications

References 86 publications

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

Thyroid axis participates in heat temperature-induced male sex reversal through its activation by the stress response

Thyroid axis participates in high-temperature-induced male sex reversal through its activation by the stress response

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